Salidroside facilitates neuroprotective effects in ischemic stroke by promoting axonal sprouting through promoting autophagy [0.03%]
红景天苷通过促进自噬促进轴突侧枝化以实现缺血性脑卒中的神经保护作用
Wenfang Lai,Yanfeng He,Binbin Zhou et al.
Wenfang Lai et al.
Background: Ischemic stroke is a common cerebrovascular disease characterized by high incidence, disability, mortality, and recurrence. The limitations of current pharmacological treatments, which have primarily single ne...
Glycyrrhizin alleviates the toxicity of hydroxychloroquine in treating oral lichen planus by occupying heat shock protein 90 alpha [0.03%]
甘草甜素通过占据热休克蛋白90α来缓解羟氯喹治疗口腔扁平苔藓的毒性作用
Houshang Wang,Jingjing Luo,Kunmeng Luo et al.
Houshang Wang et al.
Background: Oral lichen planus (OLP) is a common chronic inflammatory disease with the potential of malignant transformation. Hydroxychloroquine (HCQ), derived from quinine originating from Cinchona spp. bark, is a common...
Randomized Controlled Trial
Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Dec:135:156059. DOI:10.1016/j.phymed.2024.156059 2024
Mechanism Research of QingReJieDu Formula for Treating Hepatitis B Virus Based on Network Pharmacology [0.03%]
基于网络药理学的青热解毒方抗乙肝病毒作用机制研究
Caixia Jia,Hongxing Wu,Aiqing Yang et al.
Caixia Jia et al.
Background: Hepatitis B virus (HBV) is a DNA virus known to induce hepatitis and liver dysfunction, and is one of the main causes of liver cirrhosis and liver cancer. At present, there lacks a satisfactory optimal treatme...
Cellular and molecular mechanisms elicited by natural products, including dietary supplements, against neurological disorders [0.03%]
天然产物（包括膳食补充剂）对抗神经障碍的细胞和分子机制
Rajeev K Singla,Rohit Sharma,Bairong Shen
Rajeev K Singla
DanShen Decoction targets miR-93-5p to provide protection against MI/RI by regulating the TXNIP/NLRP3/Caspase-1 signaling pathway [0.03%]
丹参汤通过调节TXNIP/NLRP3/Caspase-1信号通路靶向miR-93-5p对MI/RI提供保护作用
Mingtai Chen,Raoqiong Wang,Lishang Liao et al.
Mingtai Chen et al.
Background: Bone marrow mesenchymal stem cells (BMSCs) derived exosomes have demonstrated potential therapeutic efficacy on myocardial ischemia/reperfusion injury (MI/RI). This study has explored the underlying mechanisms...
Ginsenoside compound K alleviates brain aging by inhibiting ferroptosis through modulation of the ASK1-MKK7-JNK signaling pathway [0.03%]
绞股蓝皂苷化合物K通过调节ASK1-MKK7-JNK信号通路抑制铁死亡从而缓解脑老化
Xiaojun Yan,Xue Bai,Guanghui Sun et al.
Xiaojun Yan et al.
Background: Aging of the brain is a major contributor to the onset and progression of neurodegenerative diseases. Conventional treatments for these diseases are often limited by significant side effects and a lack of effi...
Exploring the mechanism of Ling-Gui-Zhu-Gan decoction in metabolic cardiomyopathy via inhibiting ferroptosis [0.03%]
从抑制铁死亡角度探究苓桂竹甘汤治疗代谢性心肌病的作用机制研究
Chuan-Zhi Zhao,Hui-Min Ding,Zi-Qing Hu et al.
Chuan-Zhi Zhao et al.
Objective: This study was to investigate the mechanism of Ling-Gui-Zhu-Gan decoction (LGZGD) in regulating lipid metabolism and thus inhibiting ferroptosis. ...
Jinwu Jiangu capsule attenuates rheumatoid arthritis via the SLC7A11/GSH/GPX4 pathway in M1 macrophages [0.03%]
金乌关节丸通过M1型巨噬细胞中的SLC7A11/GSH/GPX4通路治疗类风湿性关节炎
Yi Ling,Yuzheng Yang,Nina Ren et al.
Yi Ling et al.
Background: JinWu JianGu capsule (JWJGC) is a Chinese herbal medicine that alleviates the clinical manifestations of rheumatoid arthritis (RA). However, the mechanism of action requires further investigation.. ...
Broussoflavonol F exhibited anti-proliferative and anti-angiogenesis effects in colon cancer via modulation of the HER2-RAS-MEK-ERK pathway [0.03%]
苯酚类化合物Broussoflavonol F通过调节HER2-RAS-MEK-ERK途径在结肠癌中表现出抗增殖和抗血管生成作用
Yiying Zhu,Xiaoli Li,Grace Gar-Lee Yue et al.
Yiying Zhu et al.
Background: A prenylated flavonoid, broussoflavonol F (BFF), was isolated from Macaranga genus with cytotoxicities against various cancer cells, though its underlying mechanisms have not been fully elucidated. ...
Wogonin mitigates microglia-mediated synaptic over-pruning and cognitive impairment following epilepsy [0.03%]
沃格лон因通过减轻癫痫后的突触过度修剪和认知障碍发挥微胶质细胞介导作用
Yang Hu,Honggang Qi,Jiurong Yang et al.
Yang Hu et al.
Background: Epilepsy, a neurological disorder characterized by recurrent abnormal neuronal discharges, leading to brain dysfunction and imposing significant psychological and economic burdens on patients. Microglia, the r...