Exploration the effective components of Gastrodia elata in improving cerebral ischemia reperfusion injury based on "Spectrum-effect" correlation and zebrafish verification experiment [0.03%]
基于“谱效”关联和斑马鱼验证实验探索天麻改善脑缺血再灌注损伤的有效成分
Zilu Liu,Mengting Wang,Ximeng Ding et al.
Zilu Liu et al.
Background: Gastrodia elata (GE) has been widely used in clinical practice for many years with the functions of relieving stroke, suppressing liver Yang, dispelling wind and clearing collaterals. Our group's previous expe...
Ginsenoside compound K restrains hepatic fibrotic response by dual-inhibition of GLS1 and LDHA [0.03%]
绞股蓝皂苷化合物K通过同时抑制GLS1和LDHA来限制肝纤维化反应
Wen-Hui Wu,Ya-Lan Yang,Ting Wang et al.
Wen-Hui Wu et al.
Background: Liver fibrosis is a dynamic process marked by the accumulation of extracellular matrix due to hepatic stellate cells (HSCs) activation. Ginsenoside compound K (CK), a rare derivative of its parent ginsenosides...
Semen Cuscutae-Fructus Lycii attenuates tripterygium glycosides-induced spermatogenesis dysfunction by inhibiting oxidative stress-mediated ferroptosis via the Nrf2/HO-1 pathway [0.03%]
补骨脂素和枸杞子果实提取物通过Nrf2 / HO-1途径抑制氧化应激介导的铁死亡，从而缓解雷公藤苷引起的生精功能障碍
Yutian Zhu,Jiacheng Zhang,Qiuning Liu et al.
Yutian Zhu et al.
Background: Semen Cuscutae and Fructus Lycii (SC-FL) is known for its potential therapeutic effects on spermatogenesis dysfunction. However, the underlying mechanisms of SC-FL in alleviating spermatogenesis dysfunction is...
Traditional Chinese medicine in the treatment of adverse reactions after TACE for primary hepatic carcinoma: Effect, mechanism, and potential advantages [0.03%]
中医在治疗原发性肝癌TACE术后不良反应中的作用、机制及潜在优势
Huai-Bang Li,Lin Huang,Jia-Yu Ni et al.
Huai-Bang Li et al.
Primary hepatic carcinoma is one of the most common malignant tumors. China is a major country for liver cancer, accounting for about 50 % of the patients worldwide. Although there are a variety of treatments for primary hepatic carcinoma, ...
Huang-Lian-Jie-Du decoction alleviates cognitive impairment in high-fat diet-induced obese mice via Trem2/Dap12/Syk pathway [0.03%]
黄连解毒汤通过TREM2/DAP12/SYK信号通路缓解高脂饮食诱导的肥胖小鼠的认知障碍
Jia-Yi Zheng,Rui-Kang Pang,Jiang-Hong Ye et al.
Jia-Yi Zheng et al.
Background: Cognitive impairment induced by a high-fat diet (HFD) is common, but its mechanism is largely unknown. Huang-Lian-Jie-Du (HLJD) decoction is a classical and powerful prescription in China. It consists of four ...
Flavonoids from Rhododendron nivale Hook. f ameliorate alcohol-associated liver disease via activating the PPARα signaling pathway [0.03%]
钩莲黄酮通过激活PPARα信号通路改善酒精相关性肝病
Xiao Guo,Chen Liu,Zhen Dong et al.
Xiao Guo et al.
Background: Flavonoids are increasingly recognized for their potent antioxidant properties and potential therapeutic roles in the management of alcohol-associated liver disease (ALD). Extracts derived from Rhododendron ni...
Siling decoction ameliorates adenine-induced renal fibrosis in rats by the AKT/IKKβ/NFκB signaling pathway [0.03%]
基于Akt/IKKβ/NFκB信号通路的使君子汤防治腺嘌呤致大鼠肾纤维化的作用研究
Lianlin Zeng,Yu Lin,Haixu Chen et al.
Lianlin Zeng et al.
Objective: Investigating how Siling decoction (SLD) mitigates fibrosis in rats with chronic kidney disease CKD (chronic kidney disease) through network pharmacology analysis and experimental verification. ...
Green tea polyphenol alleviates silica particle-induced lung injury by suppressing IL-17/NF-κB p65 signaling-driven inflammation [0.03%]
绿茶多酚通过抑制IL-17/NF-κB p65信号驱动的炎症缓解二氧化硅颗粒诱导的肺损伤
Yunyi Xu,Qionghua Ding,Yuhuan Xie et al.
Yunyi Xu et al.
Background: Silicosis, an interstitial lung disease caused by inhalation of silica particles, poses a significant health concern globally. Green tea polyphenol (TP) stands out as a promising therapeutic candidate, yet its...
Gnetupendin A protects against ischemic stroke through activating the PI3K/AKT/mTOR-dependent autophagy pathway [0.03%]
通过激活PI3K/AKT/mTOR依赖的自噬途径GnetupendinA防治缺血性卒中
Danyang Mu,Jingyu Liu,Yan Mi et al.
Danyang Mu et al.
Background: Autophagy has been recently emerged as a prominent factor in the pathogenesis of ischemic stroke (IS) and is increasingly being considered as a potential therapeutic target for IS. Gnetum parvifolium has been ...
Ginkgo biloba extract alleviates deltamethrin-induced testicular injury by upregulating SKP2 and inhibiting Beclin1-independent autophagy [0.03%]
银杏叶提取物通过上调SKP2和抑制Beclin1独立的自噬来缓解联苯菊酯致睾丸损伤
Huating Wang,Fan Yang,Junhua Ye et al.
Huating Wang et al.
Background: Male infertility is a worldwide concern that is associated with a decline in sperm quality. Environmental pollutants such as deltamethrin (DM) have harmful effects on male reproductive organs. By maintaining i...