Mulberry leaf benefits the intestinal epithelial barrier via direct anti-oxidation and indirect modulation of microbiota in pigs [0.03%]
桑叶通过直接抗氧化和间接调节肠道微生物群改善猪的肠上皮屏障功能
Hui Yan,Shurui Yan,Zaiyao Li et al.
Hui Yan et al.
Background: Diarrhea and intestinal dysfunction commonly occur in young mammals, causing malnutrition and growth retardation in both human and livestock. As the traditional Chinese herb, mulberry leaf contains various bio...
Liang-Ge-San protects against viral infection-induced acute lung injury through inhibiting α7nAChR-mediated mitophagy [0.03%]
梁葛散通过抑制α7nAChR介导的线粒体自噬保护病毒感染所致急性肺损伤
Jingtao Yu,Zibin Lu,Bing Chen et al.
Jingtao Yu et al.
Background: Acute lung injury (ALI) is the main cause of death in clinical respiratory virus infection. Liang-Ge-San (LGS), a famous traditional Chinese formula, has been proved to be effective in treating ALI caused by l...
Berberine in combination with evodiamine ameliorates gastroesophageal reflux disease through TAS2R38/TRPV1-mediated regulation of MAPK/NF-κB signaling pathways and macrophage polarization [0.03%]
番泻叶碱联合吴茱萸碱通过TAS2R38 / TRPV1介导的MAPK / NF- κB信号通路及巨噬细胞极化调节改善胃食管反流病
Guoliang Cui,Manli Wang,Xiaofeng Li et al.
Guoliang Cui et al.
Background: Gastroesophageal reflux disease (GERD) is a chronic condition of the digestive tract with limited therapeutic options. Bitter taste receptors (TAS2Rs) and transient receptor potential vanilloid-1 (TRPV1) are i...
The trans-differentiation promotion of parietal epithelial cells by magnesium isoglycyrrhizinate to improve podocyte injury induced by high fructose consumption [0.03%]
甘草酸镁通过促进系膜上皮细胞转分化改善果糖诱导的足细胞损伤
Wan-Ru Wang,Ying-Zhi Yang,Yu Xing et al.
Wan-Ru Wang et al.
Background: Podocytes have limited proliferative capacity, which leads to irreversible glomerular injury in diverse kidney diseases. Magnesium isoglycyrrhizinate (MgIG), a hepatoprotective agent in clinic, has been report...
Berberine modulates microglial polarization by activating TYROBP in Alzheimer's disease [0.03%]
巴布期因通过激活TYROBP调节小胶质细胞极化以治疗阿尔茨海默病
Yu Yang,Jiwen Wu,Luping Jia et al.
Yu Yang et al.
Background: Characterized by β-amyloid (Aβ) plaques, neurofibrillary tangles, and aberrant neuroinflammation in the brain, Alzheimer's disease (AD) is the most common neurodegenerative disease. Microglial polarization i...
Bushen Huoxue Yiqi formula alleviates cardiac fibrosis in ischemic heart failure through SIRT1/Notch1 pathway-mediated EndMT [0.03%]
补血活瘀益气方通过SIRT1/Notch1介导的内皮-间质转化改善心肌梗死后慢性缺血心脏重构
Cong Chen,Jie Wang,Chengzhi Hou et al.
Cong Chen et al.
Background: Cardiac fibrosis plays a crucial role in the development of heart failure (HF) following myocardial infarction (MI). Endothelial-mesenchymal transition (EndMT) is one of the key drivers of cardiac fibrosis and...
Altingia chinensis petroleum ether extract suppresses NSCLC via induction of apoptosis, attenuation of EMT, and downregulation of PI3K/Akt pathway [0.03%]
化州柚叶油素诱导肺腺癌细胞凋亡、抑制上皮间质转化并下调PI3K/Akt信号通路表达的作用及机制研究
Yiran Qin,De Zhang,Chenxin Shangguan et al.
Yiran Qin et al.
Background: Non-small-cell lung cancer (NSCLC) is the primary type of lung cancer with the leading cause of fatalities from cancer, and the effective treatment is minimal. Altingia chinensis is a medicinal plant utilized ...
Efficacy and safety of yangxinshi versus trimetazidine on exercise tolerance in patients with coronary heart disease after percutaneous coronary intervention: Multicenter, double-blind clinical trial [0.03%]
养心氏片与曲美他嗪对冠脉介入治疗后稳定性冠心病患者运动耐量的影响：多中心双盲临床试验
Yang Li,Yi Li,Zhijie Zhang et al.
Yang Li et al.
Background: Optimizing medication to improve exercise tolerance in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI) is limited. Yangxinshi tablets, an herbal-based oral medicine, r...
Randomized Controlled Trial
Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Dec:135:156198. DOI:10.1016/j.phymed.2024.156198 2024
EGCG targeting STAT3 transcriptionally represses PLXNC1 to inhibit M2 polarization mediated by gastric cancer cell-derived exosomal miR-92b-5p [0.03%]
EGCG通过靶向STAT3转录抑制PLXNC1来抑制胃癌细胞来源的外泌体miR-92b-5p介导的M2极化作用
Jianfeng Yi,Zhenzhen Ye,Hao Xu et al.
Jianfeng Yi et al.
Background: M2-polarized tumor-associated macrophages (TAMs) predominate in tumor microenvironment (TME) and serve primary functions in tumor progression, including growth, angiogenesis, metastasis, immunosuppression, che...
Targeting and degradation of OTUB1 by Erianin for antimetastasis in esophageal squamous cell carcinoma [0.03%]
环芸素通过靶向降解OTUB1发挥抗转移作用并治疗食管鳞癌
Yuan Zhu,Ningning Kang,Li Zhang et al.
Yuan Zhu et al.
Background: Metastasis is a major contributor to mortality in patients with esophageal squamous cell carcinoma (ESCC); effective treatment is currently lacking. Erianin, a bioactive ingredient of traditional Chinese medic...