Efficacy and safety of YOXINTINE for depression: A double-blinded, randomized, placebo-controlled, phase 2 clinical trial [0.03%]
盐酸育apterin治疗抑郁症的疗效和安全性：一项双盲随机安慰剂对照II期临床试验
Zaiquan Dong,Qi Shen,Hanwen Zhu et al.
Zaiquan Dong et al.
Background: YOXINTINE contains >98 % of 20(S)-protopanaxadial (PPD), a metabolic product of ginsenosides with pre-clinical neuroprotective activity. Animal experiments and previous studies have shown that PPD has good ant...
Ailanthone targets the KMT2A-MEN1 complex to suppress lung metastasis of osteosarcoma [0.03%]
使君子酚通过靶向KMT2A-MEN1复合物抑制肺转移血管生成从而治疗骨肉瘤
Jinrong Liang,Guanglei Qiao,Yawen Zhang et al.
Jinrong Liang et al.
Background: Lung metastasis is the leading cause of death in patients with osteosarcoma (OS), and new drugs are urgently needed. Epigenetic reprogramming is a recently proposed hallmark of malignancy; therefore, targeting...
Honey-fried licorice in the treatment of arrhythmia: Structure elucidation and the mechanism of antiarrhythmic activity [0.03%]
蜜制炙甘草抗心律失常作用机制及物质基础研究
Yushu Wang,Yuxin Li,Wenxin Xia et al.
Yushu Wang et al.
Aim of the study: To evaluate the therapeutic mechanism of Honey-fried licorice on arrhythmia, to explore the distribution of main components of Honey-fried licorice in vivo before and after processing, and to elucidate t...
Salvianolic acid B alleviated myocardial ischemia-reperfusion injury via modulating SIRT3-mediated crosstalk between mitochondrial ROS and NLRP3 [0.03%]
salvianolic酸B通过调节SIRT3介导的线粒体ROS和NLRP3之间的交叉谈话来缓解心肌缺血再灌注损伤
Xiao-Hong Wei,Jie Chen,Xue-Fen Wu et al.
Xiao-Hong Wei et al.
Background: Mitochondrial ROS (mtROS) accumulation and NLRP3 inflammasome activation are critical in the pathogenesis of myocardial ischemia-reperfusion injury (MIRI). However, their upstream regulatory mechanisms and int...
9-PAHSA ameliorates microvascular damage during cardiac ischaemia/reperfusion injury by promoting LKB1/AMPK/ULK1-mediated autophagy-dependent STING degradation [0.03%]
9-PAHSA通过促进LKB1/AMPK/ULK1介导的自噬依赖性STING降解来改善心脏缺血再灌注损伤期间的微血管损害
Wenhu Liu,Jing Hu,Ya Wang et al.
Wenhu Liu et al.
Background: Considering that cardiac microvascular injury may play a more critical role than cardiomyocyte injury in the pathology of early ischaemia/reperfusion (I/R) injury, therapeutic strategies targeting the microvas...
20(R)-ginsenoside Rg3 alleviates diabetic retinal injury in T2DM mice by attenuating ROS-mediated ER stress through the activation of the Nrf2/HO-1 axis [0.03%]
绞股蓝苷Rg3通过激活Nrf2/HO-1轴来减轻2型糖尿病小鼠的视网膜损伤及氧化应激介导的内质网压力
Wen-Lin Li,Ke Li,Wen-Guang Chang et al.
Wen-Lin Li et al.
Background: Although our previous work confirmed 20(R)-ginsenoside Rg3 (R-Rg3), which is an active ingredient in the Panax Ginseng C.A. Meyer, to have good anti-diabetic activity, its beneficial effect on diabetic retinal...
Dachengqi decoction ameliorated liver injury in liver fibrosis mice by maintaining gut vascular barrier integrity [0.03%]
大承气汤通过维持肠道血管屏障的完整性改善肝纤维化小鼠的肝损伤
Wang Shuhan,Li Jinxiao,Shang Luorui et al.
Wang Shuhan et al.
Background: Severe liver fibrosis may be accompanied by intestinal barrier damage, such as bacterial peritonitis, suggesting that the role of the gut-liver axis is nonnegligible. Dachengqi decoction (DCQD) was reported to...
Saffron and its major constituents against neurodegenerative diseases: A mechanistic review [0.03%]
番红花及其主要成分在神经退行性疾病中的作用：机制综述
Sadaf Abdian,Sajad Fakhri,Seyed Zachariah Moradi et al.
Sadaf Abdian et al.
Background: Neurodegeneration has been recognized as the main pathophysiological alteration in the majority of brain-related diseases. Despite contemporary attempts to provide acceptable medicinal therapies, the conclusio...
Phytosesquiterpene lactones deregulate mitochondrial activity and phenotypes associated with triple-negative breast cancer metastasis [0.03%]
植物倍半萜内酯可调节与三阴性乳腺癌转移相关的线粒体功能和表型
Yu-Ting Cheng,Dao-Ming Chang,Yi-Chung Tung et al.
Yu-Ting Cheng et al.
Background: Triple-negative breast cancer (TNBC) recurrence and metastasis are the major causes of failure in TNBC therapy. The difficulties in treating TNBCs may be because of increased cancer cell plasticity that involv...
Genus Bauhinia (Fabaceae): A review from phytochemistry to pharmacology- Exploring traditional uses and toxicological insights across Asia [0.03%]
羊蹄甲属（豆科）的化学和药理研究——亚洲传统用途及毒理学见解探索
Rupali Verma,Shubham Dash,Ankita et al.
Rupali Verma et al.
Background: The genus Bauhinia and its species has been known since ages by tribal people and medicinal practitioners in tropical and subtropical regions for the treatment of diabetes, diarrhea, cough, fever, stomach diso...