Xiyangshen Sanqi Danshen granules attenuated D-gal-induced C57BL/6J mouse aging through the AMPK/SIRT1 signaling pathway [0.03%]
西洋参三七丹参颗粒通过AMPK/SIRT1信号通路干预D-半乳糖致C57BL/6J小鼠衰老的作用研究
Zhiru Yin,Liangliang Tian,Wenzhuo Kou et al.
Zhiru Yin et al.
Background: Aging is a pressing global concern and is frequently accompanied by the emergence of many chronic diseases. Xiyangshen Sanqi Danshen granules (XSD) have antioxidant, anti-inflammatory and anti-fatigue function...
Modified Zuojin pill alleviates gastric precancerous lesions by inhibiting glycolysis through the HIF-1α pathway [0.03%]
Modified Zuojin Pill通过抑制HIF-1α介导的糖酵解治疗胃癌前病变
Shan Liu,Haijie Ji,Tai Zhang et al.
Shan Liu et al.
Background: Gastric precancerous lesions (GPL) typically originates from chronic gastritis (CG), and the changes in glycolysis mediated by the HIF-1α pathway during the progression from CG to GPL are unclear. Modified Zu...
Corrigendum to Peanut (Arachis hypogaea L.) seeds and by-products in metabolic syndrome and cardiovascular disorders: A systematic review of clinical studies Phytomedicine 123 (2024) 155170 [0.03%]
关于花生（Arachis hypogaea L.）种子和副产品在代谢综合征和心血管疾病中的作用的系统评价的勘误说明《药用植物医学》123期（2024年）155170号论文
Yandra Cervelim Nunes,Gian de Oliveira Santos,Nathália Mendes Machado et al.
Yandra Cervelim Nunes et al.
Background: Cardiovascular diseases (CVDs) are the leading causes of death worldwide. The main risk factors are hypertension, diabetes, obesity, and increased serum lipids. The peanut (Arachis hypogaea L.), also known as ...
Cannabidiol regulates L-carnitine and butyric acid metabolism by modulating the gut microbiota to ameliorate collagen-induced arthritis [0.03%]
大麻二酚通过调节肠道菌群来调控L-肉碱和丁酸代谢以改善胶原诱导的关节炎
Qishun Geng,Zhaoran Wang,Tong Shi et al.
Qishun Geng et al.
Background: Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, affecting multiple systems in the body. Cannabidiol (CBD) is one of the most medically valuable active ingredients in cannabis. At prese...
Emodin disrupts the KITENIN oncogenic complex by binding ErbB4 and suppresses colorectal cancer progression in dual blockade with KSRP-binding compound [0.03%]
大黄素通过与ErbB4结合干扰KITENIN致癌复合体并在与靶向KSRP的化合物联用时抑制结直肠癌进展
Mücahit Varlı,Moongi Ji,Eunae Kim et al.
Mücahit Varlı et al.
Background: The KITENIN/ErbB4 complex has been reported to participate in metastasis, which is the principal reason of death in most colorectal cancer patients. ...
Guizhi Shaoyao Zhimu decoction inhibits neutrophil extracellular traps formation to relieve rheumatoid arthritis via gut microbial outer membrane vesicles [0.03%]
桂枝芍药知母汤通过肠道微生物外膜囊泡抑制中性粒细胞胞外诱捕网的形成从而缓解类风湿关节炎
Haixin Ye,Hao Wang,Bingqi Han et al.
Haixin Ye et al.
Background: Rheumatoid arthritis (RA) is a common autoimmune disease with a high disability rate. Accumulating studies suggest that neutrophil extracellular traps (NETs) play a crucial role in the pathogenesis of RA and t...
Arabinogalactan from Cynanchum atratum induces tolerogenic dendritic cells in gut to restrain autoimmune response and alleviate collagen-induced arthritis in mice [0.03%]
防己地上部分多糖通过诱导肠道耐受性树突状细胞抑制自身免疫反应而缓解小鼠胶原诱导性关节炎
Ning Li,Tianhao Xu,Zhaoshun Wu et al.
Ning Li et al.
Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by multiple joints lesions. Tolerogenic dendritic cells (tolDCs) play crucial roles in maintaining immune homeostasis. The immunomodulatory acti...
Cryptotanshinone alleviates immunosuppression in endometriosis by targeting MDSCs through JAK2/STAT3 pathway [0.03%]
cryptotanshinone通过JAK2/STAT3信号通路靶向MDSCs治疗子宫内膜异位症相关免疫抑制作用
Linling Xie,Yu Zhong,Yi Chen et al.
Linling Xie et al.
Background: Endometriosis (EMS), a well-recognized chronic inflammatory disorder, characterized by significant immune dysregulation, in which myeloid-derived suppressor cells (MDSCs) are essential for facilitating immunos...
Autocrine and paracrine LIF signals to collaborate sorafenib-resistance in hepatocellular carcinoma and effects of Kanglaite Injection [0.03%]
自分泌和旁分泌LIF信号促进肝癌索拉非尼耐药及康莱特注射液的干预作用
Yingying Shao,Weiling Pu,Ranran Su et al.
Yingying Shao et al.
Background: Sorafenib (SFN) is the first-line medicine for advanced hepatocellular carcinoma (HCC). However, Sorafenib resistance is a main challenge of therapeutic efficacy, and the mechanisms have not been fully clarifi...
Mechanistic insights into the treatment of pulmonary fibrosis with bioactive components from traditional chinese medicine via matrix stiffness-mediated EMT [0.03%]
通过基质硬度介导的上皮间质转化探讨传统中药活性成分治疗肺纤维化的机制
Kangchen Li,Han Liu,Mingyan Li et al.
Kangchen Li et al.
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options. Our previous research has shown that the Jinshui Huanxian formula (JHF) is effective in treating...