CIP2A inhibitors TD52 and Ethoxysanguinarine promote macrophage autophagy and alleviates acute pancreatitis by modulating the AKT-mTOR pathway [0.03%]
CIP2A抑制剂TD52和Ethoxysanguinarine通过调节AKT-mTOR信号通路促进巨噬细胞自噬并缓解急性胰腺炎
Zhu Liu,Tan Zhang,Akmal Ergashev et al.
Zhu Liu et al.
Background: Acute pancreatitis (AP) is a prevalent and serious condition within the digestive system, with approximately 20 % to 30 % of cases advancing to severe acute pancreatitis (SAP). During the initial phases of SAP...
Advances in the application of network analysis methods in traditional Chinese medicine research [0.03%]
网络药理学方法在中医药研究中的应用进展
Defu Tie,Mulan He,Wenlong Li et al.
Defu Tie et al.
Objective: This review aims at evaluating the role and potential applications of network analysis methods in the medicinal substances of traditional Chinese medicine (TCM), theories of TCM compatibility, properties of her...
Effusol ameliorates ischemic stroke by targeting NLRP3 protein to regulate NLRP3 inflammasome-mediated pyroptosis [0.03%]
Effusol通过靶向NLRP3蛋白调节NLRP3炎性小体介导的细胞焦亡改善缺血性卒中
Libin Xu,Siyu Li,Jiaxin Qi et al.
Libin Xu et al.
Background: The significance of pyroptosis as an inflammatory mode of death in ischemic stroke (IS) has attracted much attention in recent years. Effusol is a dihydrophenanthrene component extracted from Juncus effusus L....
Exploring Cistanche's therapeutic potential and molecular mechanisms in asthma treatment [0.03%]
肉苁蓉治疗哮喘的药理潜力及分子机制研究
Jiliu Liu,Jie Gao,Anying Xiong et al.
Jiliu Liu et al.
Asthma, a prevalent chronic respiratory disease, is characterized by airway inflammation and hyperresponsiveness, significantly impacting global health. Current treatments, including corticosteroids, face limitations due to variable patient...
Proanthocyanidins alleviate acute alcohol liver injury by inhibiting pyroptosis via inhibiting the ROS-MLKL-CTSB-NLRP3 pathway [0.03%]
原花青素通过抑制ROS-MLKL-CTSB-NLRP3途径抑制焦亡从而改善急性酒精性肝损伤
Yingli Jin,Chunyun Wang,Zhuoqun Meng et al.
Yingli Jin et al.
Background: Alcoholic Liver Disease (ALD) is a hepatic disorder resulting from prolonged or excessive alcohol intake. The predominant manifestation of ALD is fatty liver, which progresses to alcoholic hepatitis as the dis...
S6K/FLNC/ITGβ3 signaling pathway regulates osteoclastogenesis and the inhibition of osteoclastogenesis by columbianadin [0.03%]
S6K/FLNC/ITGβ3信号通路调控破骨细胞生成及哥伦比亚酰胺抑制破骨细胞生成的作用及机制研究
Qiu Wei,Zi-Chang Niu,Xiao-Yu Fu et al.
Qiu Wei et al.
Background: Over-activation of osteoclastogenesis is a significant factor contributing to bone loss, leading to increased resorption of bone. Columbianadin (CBN), a compound derived from Angelicae Pubescentis Radix, has t...
Sishen Pill & Tongxieyaofang ameliorated ulcerative colitis through the activation of HIF-1α acetylation by gut microbiota-derived propionate and butyrate [0.03%]
四神丸与痛泻要方通过肠道菌群短链脂肪酸激活HIF-1α乙酰化改善溃疡性结肠炎
Haifan Liu,Dunfang Wang,Xue Feng et al.
Haifan Liu et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease closely related to gut microbiota dysbiosis and intestinal homeostasis imbalance. Sishen Pill&Tongxieyaofang (SSP-TXYF) has a long history of app...
Thermo-responsive hydrogel loading hypericin induces pro-inflammatory response against Trichinella spiralis infection via toll-like receptor 3 activation [0.03%]
载有 hypericin 的热响应水凝胶通过 toll 样受体 3 激活诱导对旋毛虫感染的促炎反应
Lingfeng Xie,Ning Jiang,Yi Liu et al.
Lingfeng Xie et al.
Background: Trichinella spiralis can cause animal and human trichinellosis, which is fatal for human beings. Study demonstrated that toll-like receptor 3 (TLR3) agonist was effective in reducing trichinella infections. Hy...
Multi-omics analysis reveals the protective effects of Chinese yam polysaccharide against cisplatin-induced renal interstitial fibrosis [0.03%]
多组学分析揭示山药多糖对抗顺铂诱导的肾间质纤维化的保护作用
Meizhen Wei,Shurui Chen,Zhenguang Huang et al.
Meizhen Wei et al.
Background: Chinese yam polysaccharide (SYDT) has been reported to protect renal function and mitigate renal fibrosis in mice with diabetic nephropathy. Based on a multi-omics analysis, the objectives of this study were t...