Plumbagin alleviates muscle atrophy in female mice through inhibiting the DANCR/NF-κB axis [0.03%]
Plumbagin通过抑制DANCR/NF-κB轴缓解雌性小鼠肌肉萎缩
Yu Liu,Honglin Chen,You Zhang et al.
Yu Liu et al.
Background: Muscle atrophy is a condition of the skeletal muscular system closely related to inflammation and significantly affects a person's quality of life and physical activity. It is characterized primarily by the pr...
Qingke Pingchuan granules alleviate airway inflammation in COPD exacerbation by inhibiting neutrophil extracellular traps in mice [0.03%]
清可平喘颗粒通过抑制中性粒细胞胞外诱捕网改善慢性阻塞性肺疾病急性加重期小鼠气道炎症
Mengxin Cheng,Xi Yan,Yu Wu et al.
Mengxin Cheng et al.
Background: Chronic obstructive pulmonary disease (COPD) imposes a significant global health and socioeconomic burden. Exacerbations of COPD (ECOPD), characterized by heightened airway inflammation and mucus hypersecretio...
Jiawei Qi Gong Wan improves liver fibrosis and inflammation in PCOS mice via the Akt2-FoxO1 and YAP/TAZ signaling pathways [0.03%]
姬威气功丸通过Akt2-FoxO1和YAP/TAZ信号通路改善PCOS小鼠肝纤维化和炎症
Jie Li,Ruqun Zheng,Yingyan Shen et al.
Jie Li et al.
Background: Metabolic disorders in polycystic ovary syndrome (PCOS) patients have attracted increasing attention, and nonalcoholic fatty liver disease (NAFLD) in particular has been the focus of much research due to its h...
Ginsenoside RK3 inhibits glioblastoma by modulating macrophage M2 polarization via the PPARG/CCL2 axis [0.03%]
人参皂苷RK3通过PPARG/CCL2轴调节巨噬细胞M2极化抑制胶质母细胞瘤
Haiying Zhang,Jinpeng Hu,Xiang Zhao et al.
Haiying Zhang et al.
Background: Glioblastoma is recognized as the most aggressive form of intracranial tumor, presenting significant challenges in treatment. Recent emphasis has been placed on the potential of traditional Chinese medicine (T...
The potential immunotherapy effect of Ginkgolide B thwarts oral squamous cell carcinoma progression by targeting the SREBP1/KLK8/CCL22 axis [0.03%]
银杏内酯B通过靶向SREBP1/KLK8/CCL22轴具有潜在的免疫治疗效果以抑制口腔鳞状细胞癌的发展
De-Wei Lai,Pei-Yi Chu,Meei-Ling Sheu et al.
De-Wei Lai et al.
Background: Oral cancer is a malignant tumor of the oral cavity, with regulatory T cell (Treg) infiltration associated with poor prognosis. Ginkgolide B (GB) has demonstrated effects on lipid metabolism; however, its pote...
Bruceine A inhibits TGF-β1/Smad pathway in pulmonary fibrosis by blocking gal3/TGF-β1 interaction [0.03%]
Bruceine A通过阻断gal3/TGF-β1相互作用抑制肺纤维化中的TGF-β1/Smads途径
Chao Du,Chong Ma,Ruoyu Geng et al.
Chao Du et al.
Background: Bruceine A(BA) has many pharmacological activities and significantly inhibits fibrosis in keloid fibroblasts. However, the underlying mechanisms have not yet been fully elucidated. ...
Cyclovirobuxine D inhibits triple-negative breast cancer via YAP/TAZ suppression and activation of the FOXO3a/PINK1-Parkin pathway-induced mitophagy [0.03%]
_CYC病毒环巴克素D通过抑制YAP / TAZ和诱导FOXO3a / PINK1-Parkin途径活化线粒体自噬来抑制三阴性乳腺癌_
Zi-Qiong Wang,Zhi-Xuan Wu,Jia-Wei Chen et al.
Zi-Qiong Wang et al.
Background: Triple-negative breast cancer (TNBC) is characterized by its rapid progression and aggressive nature, with limited effective therapeutic interventions currently available. Cyclovirobuxine D (CVB-D), a natural ...
Xibining inhibition of the PI3K-AKT pathway reduces M1 macrophage polarization to ameliorate KOA synovial inflammation and nociceptive sensitization [0.03%]
抑制PI3K-AKT信号通路可减轻膝骨关节炎滑膜炎症和痛觉过敏症状并减少M1型巨噬细胞极化
Lishi Jie,Li Zhang,Houyu Fu et al.
Lishi Jie et al.
Background: Pain is the most critical symptom of knee osteoarthritis(KOA), which seriously affects the quality of life of patients. Xibining (XBN), a traditional herbal compound, has achieved good results in the clinical ...
Toosendanin alleviates acute lung injury by reducing pulmonary vascular barrier dysfunction mediated by endoplasmic reticulum stress through mTOR [0.03%]
藤黄酸通过mTOR缓解内质网应激介导的肺血管屏障功能障碍以治疗急性肺损伤
Xiaocheng Mao,Cheng Wang,Hong Tang et al.
Xiaocheng Mao et al.
Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe clinical conditions with limited treatment options. Toosendanin (TSN), a triterpenoid compound with anti-inflammatory effects, ...
Isoquercitrin promotes hair growth through induction of autophagy and angiogenesis by targeting AMPK and IGF-1R [0.03%]
异檞皮素通过靶向AMPK和IGF-1R诱导自噬和血管生成从而促进毛发生长
Majid Manzoor,Danni Chen,Jiahui Lin et al.
Majid Manzoor et al.
Background: Hair follicles play a crucial role in hair growth, wound healing, thermoregulation, and sebum production. Hair loss affects millions of people worldwide, yet therapeutic options for managing hair loss and patt...