Qingfei Yin alleviates Streptococcus pneumoniae pneumonia by promoting complete autophagy to suppress necroptosis [0.03%]
清菲饮通过促进完全性自噬来抑制坏死性凋亡从而治疗肺炎链球菌肺炎
Tong Tian,Zhilong Xue,Xiaozhou Sun et al.
Tong Tian et al.
Background: Bacterial pneumonia is most prevalent among all pneumonia types, with Streptococcus pneumoniae being the main pathogen. Qingfei Yin (QFY) is a traditional Chinese medicine formula used in the clinical treatmen...
Sarsasapogenin stimulates angiogenesis and osteogenesis coupling to treat estrogen deficiency-induced osteoporosis by activating the GPX4/SLIT3/ROBO1 axis [0.03%]
萨斯 Sapogenin通过激活GPX4/SLIT3/ROBO1轴治疗雌激素缺乏引起的骨质疏松症
Fang Wang,Fanxuan Zhang,Bingfeng Lin et al.
Fang Wang et al.
Background: Promoting the coupling of osteogenesis and angiogenesis is a crucial strategy for the treatment of postmenopausal osteoporosis (PMOP). Estrogen deficiency induces ferroptosis, which is closely associated with ...
Andrographolide attenuates SARS-CoV-2 infection via an up-regulation of glutamate-cysteine ligase catalytic subunit (GCLC) [0.03%]
安滴素通过上调谷氨酸半胱氨酸连接酶催化亚基(GCLC)抑制SARS-CoV-2感染
Jarinya Chaopreecha,Nut Phueakphud,Ampa Suksatu et al.
Jarinya Chaopreecha et al.
Background: Andrographolide is a medicinal compound which possesses anti-SARS-CoV-2 activity. A number of cellular targets of andrographolide have been identified by target predictions and computational studies. ...
Bushen Jianpi Tiaoxue Decoction (BJTD) ameliorates oxidative stress and apoptosis induced by uterus ageing through activation of the SIRT1/NRF2 pathway [0.03%]
补肾健脾调血汤通过激活SIRT1/NRF2信号通路改善子宫衰老导致的氧化应激和凋亡
Jiacheng Zhang,Hangqi Hu,Yutian Zhu et al.
Jiacheng Zhang et al.
Background: Uterus ageing is a crucial factor contributing to decreased fertility in older women and is also implicated in menstrual disorders, endometritis, and adenomyosis. Bushen Jianpi Tiaoxue Decoction (BJTD) is a tr...
Long term Coptidis Rhizoma intake induce gastrointestinal emptying inhibition and colon barrier weaken via bitter taste receptors activation in mice [0.03%]
黄连长期摄入通过激活苦味受体诱导小鼠胃肠排空抑制和结肠屏障削弱
Zhizhongbin Wu,Wei Yang,Tianyue Wu et al.
Zhizhongbin Wu et al.
Background: Coptidis Rhizoma, a classic bitter traditional Chinese medicine, can lead to digestive dysfunction when long-term use according to traditional experience. Bitter taste receptors have been found to regulate gas...
Study on the anti-Parkinson's disease activity mechanism and preparation of panaxadiol [0.03%]
人参皂苷原人参二醇抗帕金森病活性机制研究及原人参二醇的制备
Lei Xu,Zhongjin Zhang,Ziqi Feng et al.
Lei Xu et al.
Background: Traditional Chinese medicine offers unique and valuable resources for the exploration of novel approaches to disease treatment. Panaxadiol, an active compound derived from the transformation of ginsenosides. I...
The double face of licorice-kansui herb pair: Cure or curse, depending on the combining ratio and mediated by hydrogen sulfide [0.03%]
双面甘遂甘草配伍：比例决定疗效，氢硫酸依存调控机制判生死
Na Li,Wen Xue,Chaoping Wang et al.
Na Li et al.
Background: The safety and efficacy of herbal medicines including traditional Chinese medicine (TCM) has been one of the major scientific problems in the medical field. In TCM prescriptions, reasonable herbal combinations...
Effect of stem extract of Schisandra Chinensis on improving spermatogenesis disorder induced by Cisplatin in Vivo and in Vitro [0.03%]
五味子茎提取物改善顺铂致生精障碍的体内及体外实验研究
Hao Zhang,Yu-Zhuo Zhang,Wei Liu et al.
Hao Zhang et al.
Background: The primary adverse effect of chemotherapy drugs is the induction of spermatogenic disorders. Schisandra chinensis (Turcz) Baill. have been preliminarily shown to have a significant ameliorative in spermatogen...
Bioinformatics and molecular docking reveal Cryptotanshinone as the active anti-inflammation component of Qu-Shi-Xie-Zhuo decoction by inhibiting S100A8/A9-NLRP3-IL-1β signaling [0.03%]
基于生物信息学和分子对接技术揭示秦艽消浊汤抗炎有效成分及其作用机制
Xiao-Zhong Liao,Rui-Xia Xie,Song-Yuan Zheng et al.
Xiao-Zhong Liao et al.
Background: Gout is a common type of arthritis marked by monosodium urate (MSU) crystal deposition in joints, triggering an inflammatory response. Qu-Shi-Xie-Zhuo (QSXZ), a traditional Chinese medicine (TCM) formula, has ...
Exploring the mechanism of Taohong Siwu Decoction in treating ischemic stroke injury via the circDnajc1/miR-27a-5p/C1qc signaling axis [0.03%]
基于circDnajc1/miR-27a-5p/C1QC信号轴探讨桃红四物汤治疗缺血性卒中损伤的作用机制
Yumeng Li,Qingping Ye,Jingjing Li et al.
Yumeng Li et al.
Background: Ischemic stroke (IS) is the most prevalent type of cerebrovascular disease. Taohong Siwu Decoction (THSWD) has been demonstrated to have neuroprotective benefits during Cerebral Ischemia-Reperfusion Injury (CI...