Isobicyclogermacrenal ameliorates hippocampal ferroptosis involvement in neurochemical disruptions and neuroinflammation induced by sleep deprivation in rats [0.03%]
异 bicyclogermacrenal改善睡眠剥夺引起的大鼠海马神经化学异常和神经炎症介导的铁死亡参与
Ao Yan,Zhejin Li,Yuanwei Gao et al.
Ao Yan et al.
Background: Sleep deprivation (SLD) is a widespread condition that disrupts physiological functions and may increase mortality risk. Valeriana officinalis, a traditional medicinal herb known for its sedative and hypnotic ...
Phillygenin improves diabetic nephropathy by inhibiting inflammation and apoptosis via regulating TLR4/MyD88/NF-κB and PI3K/AKT/GSK3β signaling pathways [0.03%]
Phillygenin通过调节TLR4/MyD88/NF-κB和PI3K/AKT/GSK3β信号通路抑制炎症和凋亡从而改善糖尿病肾病
Qi Feng,Xiaoyue Yu,Junwei Xie et al.
Qi Feng et al.
Background: Phillygenin (PHI), a main bioactive compound found in the fruit of Forsythia suspensa, exhibits antiviral, antioxidant, anti-inflammatory, and antihypertensive activities. However, the molecular mechanisms und...
Rosavin derived from Rhodiola alleviates colitis in mice through modulation of Th17 differentiation [0.03%]
Rhodiola中提取的罗索辛通过调节Th17分化缓解小鼠结肠炎
Yi Wang,Yu Jiang,Mingxing Li et al.
Yi Wang et al.
Background: Rosavin (RSV) is a naturally occurring compound isolated from Rhodiola species. While RSV has been reported with pharmacological activities of anti-oxidation, anti-inflammation, anti-stress and immunomodulatio...
Quercetin inhibits hydrogen peroxide-induced cleavage of heat shock protein 90 to prevent glutathione peroxidase 4 degradation via chaperone-mediated autophagy [0.03%]
槲皮素通过分子伴侣介导的自噬抑制H2O2诱导的热休克蛋白90切割以防止谷胱甘肽过氧化物酶4降解
Caiwang Peng,Hengli Li,Qingling Mao et al.
Caiwang Peng et al.
Background: Oxidative stress is caused by the accumulation of reactive oxygen species (ROS) and the depletion of free radical scavengers, which is closely related to ferroptosis in diseases. Quercetin, as a natural flavon...
Casticin inhibits proliferation of Non-small cell lung cancer cells through regulating reprogramming of glucose metabolism [0.03%]
casticin通过调节重新编程的葡萄糖代谢抑制非小细胞肺癌细胞增殖
Jingyi Wei,Guangyan Lei,Qiang Chen et al.
Jingyi Wei et al.
Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with poor prognosis due to its rapid progression and resistance to existing therapies. Metabolic reprogramming, particularly alteratio...
Wolfberry (Lycium barbarum) glycopeptide attenuates dopaminergic neurons loss by inhibiting lipid peroxidation in Parkinson's disease [0.03%]
枸杞多糖通过抑制脂质过氧化作用缓解帕金森病中多巴胺能神经元的损失
Xiao-Min Lin,Meng Wang,Xin Xiao et al.
Xiao-Min Lin et al.
Background: Parkinson's disease (PD) is a common neurodegenerative disorder characterized clinically by motor dysfunction due to gradual loss of dopaminergic neurons in the nigrostriatal system. Currently, medications suc...
Unveiling the impact of traditional Chinese herbal medicines on cutaneous adverse drug reactions: A landmark 15-year nationwide study [0.03%]
揭示传统中药对皮肤不良反应影响的里程碑式十五年全国研究
Shan He,Jin Yang,Fanping Yang et al.
Shan He et al.
Background: Traditional Chinese herbal medicines (TCMs) have become increasingly integrated into global healthcare systems, often used alongside conventional pharmaceuticals. While TCMs offer therapeutic benefits, their c...
Comparative efficacy of Chinese tonic medicines for treating sepsis or septic shock: A systematic review and Bayesian network meta-analysis of randomized controlled trials [0.03%]
补肾中药治疗脓毒症或脓毒性休克疗效的系统评价和贝叶斯网络Meta分析
Rui Yang,Cheng Hu,Yuxin Zhuo et al.
Rui Yang et al.
Background: Sepsis or septic shock is a life-threatening medical emergency with a poor prognosis and a high economic burden for both individuals and healthcare resources. Evidence suggests that Chinese tonic medicines (CT...
Icariin promoted ferroptosis by activating mitochondrial dysfunction to inhibit colorectal cancer and synergistically enhanced the efficacy of PD-1 inhibitors [0.03%]
淫羊藿黄素通过激活线粒体功能障碍促进铁死亡从而抑制结直肠癌及与PD-1抑制剂的协同作用研究
Wang Haoyue,Sun Kexiang,Tan Wei Shan et al.
Wang Haoyue et al.
Background: A controlled type of cell death called ferroptosis is linked to increased reactive oxygen species (ROS), lipid peroxidation, and iron buildup. Furthermore, evidence indicates that ferroptosis may act as an imm...
Saikosaponins from Bupleurum scorzonerifolium Willd. alleviates microglial pyroptosis in depression by binding and inhibiting P2X7 expression [0.03%]
防风草皂苷通过结合并抑制P2X7表达来缓解抑郁症小胶质细胞焦亡
Yu Bi,Mengmeng Li,Yue Wang et al.
Yu Bi et al.
Background: The major depressive disorder (MDD) is a heterogeneous condition and characterized by a high recurrence rate, with neuroinflammation playing a significant role in its various potential pathologies. In recent y...