Kechuan Decoction mitigates apoptosis of airway epithelial cells by improving lipid metabolism disorders and mitochondria dysfunction in HDM-induced asthma [0.03%]
羌活胜湿汤通过改善脂质代谢紊乱及线粒体功能障碍抑制屋尘螨诱导的哮喘气道上皮细胞凋亡
Binshu Zhao,Chen Shi,Xuan Wang et al.
Binshu Zhao et al.
Background: The airway epithelium serves as the first line of defense between the lung's internal environment and the external environment, functioning through physical barriers and mucus-ciliary clearance to protect agai...
Sesquiterpene lactone from Artemisia argyi inhibited cancer proliferation by inducing apoptosis and ferroptosis via key cell metabolism enzyme NDUFA4 [0.03%]
艾叶中的倍半内酯通过关键细胞代谢酶NDUFA4诱导凋亡及铁死亡抑制肿瘤增殖
Ziling Wang,Zhouyuan Li,Rongsheng Ji et al.
Ziling Wang et al.
Background: Artemisia argyi is a well-known medicinal plant. A. argyi has been widely used in clinical for about 3000 years, owing to its extensive pharmacological activity. Among these, its anti-cancer properties are the...
Taraxasterol regulates p53 transcriptional activity to inhibit pancreatic cancer by inducing MDM2 ubiquitination degradation [0.03%]
塔拉扎斯特醇通过诱导MDM2泛素化降解调节p53转录活性抑制胰腺癌
Anna Han,Jiajing Liu,Pan Du et al.
Anna Han et al.
Background: Pancreatic cancer (PC) is a malignant tumor with complex development mechanisms and a poor prognosis. Taraxasterol (TAX), a pentacyclic triterpenoid plant sterol derived from Taraxacum mongolicum, has multiple...
Pimpinellin mitigates DSS-induced ulcerative colitis in mice by reducing inflammation and regulating gut microbiota [0.03%]
pimpinellin通过减少炎症和调节肠道微生物群来缓解小鼠DSS诱导的溃疡性结肠炎
Bin Lv,Lu Hou,Haolong Zhang et al.
Bin Lv et al.
Background: Pimpinellin is a phenylpropanoid compound involved in various physiological and pathological processes in the body. The specific impact of pimpinellin on ulcerative colitis (UC) remains uncertain. Research on ...
Asiaticoside alleviated NAFLD by activating Nrf2 and inhibiting the NF-κB pathway [0.03%]
天冬淫羊藿皂苷通过激活Nrf2和抑制NF-κB通路改善非酒精性脂肪肝病
Yunfei Wei,Yibo Zhang,Baihe Zhan et al.
Yunfei Wei et al.
Background: Nonalcoholic fatty liver disease (NAFLD) is a globally prevalent clinical problem of chronic liver disorder whose main pathogenic mechanisms are hepatic lipid accumulation, oxidative stress, and inflammatory r...
Luteolin alleviated calcium oxalate crystal induced kidney injury by inhibiting Nr4a1-mediated ferroptosis [0.03%]
黄酮类化合物山柰素通过抑制Nr4a1介导的铁死亡来缓解草酸钙晶体所致肾损伤
Zehua Ye,Songyuan Yang,Lijia Chen et al.
Zehua Ye et al.
Background: The global incidence of calcium oxalate (CaOx) kidney stones is rising, and effective treatments remain limited. Luteolin (Lut), a naturally flavonoid present in several plants, is recognized for its anti-infl...
Total saponins from Panax japonicus mediate the paracrine interaction between adipocytes and macrophages to promote lipolysis in the adipose tissue during aging via the NLRP3 inflammasome/GDF3/ATGL axis [0.03%]
人参皂苷通过NLRP3炎症小体/GDF3/ATGL轴介导脂肪细胞和巨噬细胞旁分泌相互作用促进衰老过程中脂肪组织脂解作用
Fangqi Xia,Yaqi Hu,Yaqi Wang et al.
Fangqi Xia et al.
Adipocytic lipolysis is strongly related to the increase of visceral fat, decrease of exercise capacity, and various other metabolic syndromes during aging. It is significantly influenced by the paracrine relationship between adipocytes and...
Isoliquiritin targeting m5C RNA methylation improves mitophagy in doxorubicin-induced myocardial cardiotoxicity [0.03%]
异黄酮隔离liqueiritin通过靶向m5C RNA甲基化改善多柔比星诱导的心肌细胞自噬作用以对抗心肌毒性损伤
Jiaqi Fu,Li Cheng,Jie Zhang et al.
Jiaqi Fu et al.
Background: Doxorubicin (DOX)-induced myocardial cardiotoxicity (DIC) severely limits its clinical application, and there is no optimal therapeutic agent available. Recent studies revealed that activation of BNIP3-mediate...
Modified Jiaoqi Powder enhances epithelial autophagy against TNF-triggered apoptosis in chronic ulcerative colitis [0.03%]
Modified Jiaoqi Powder增强上皮细胞自噬对抗慢性溃疡性结肠炎肿瘤坏死因子诱导的凋亡作用
Weiping Liu,Xingrui Yan,Jinqi An et al.
Weiping Liu et al.
Background: A vicious cycle of dysregulated intestinal epithelial cell death, intestinal barrier defect, and subsequent inflammation response is core to chronic ulcerative colitis (UC). Modified Jiaoqi Powder (MJQP), a tr...
Efficacy and safety of Dachaihu decoction for sepsis: A randomized controlled trial [0.03%]
大柴胡汤治疗全身炎症反应综合征的临床疗效观察：随机对照试验研究
Na Huang,Yat Hoi Tam,Zhitong Zhang et al.
Na Huang et al.
Background: Sepsis is a critical condition characterized by multi-organ dysfunction (MODS) that presents significant treatment challenges. Traditional Chinese medicine (TCM), particularly Dachaihu decoction (DCH), has sho...