Gastrodin: Modulating the xCT/GPX4 and ACSL4/LPCAT3 pathways to inhibit ferroptosis after ischemic stroke [0.03%]
天麻苷通过调节xCT/GPX4和ACSL4/LPCAT3通路抑制缺血性脑卒中后铁死亡的作用机制研究
Cuilan Gong,Xinying Fu,Qiang Ma et al.
Cuilan Gong et al.
Ischemic stroke ranks as the second leading cause of global mortality and disability. Although reperfusion is crucial for salvaging brain tissue, it carries the risk of secondary injuries, such as ferroptosis. Gastrodin, a neuroprotective c...
Sanguinarine suppresses oral squamous cell carcinoma progression by targeting the PKM2/TFEB aix to inhibit autophagic flux [0.03%]
血根碱通过靶向PKM2/TFEB轴抑制自噬流来抑制口腔鳞状细胞癌进展
Yong-Chun Peng,Zhi-Jing He,Lun-Cai Yin et al.
Yong-Chun Peng et al.
Background: Oral squamous cell carcinoma (OSCC) is one of the most common malignancies. However, there is no effective treatment for OSCC. Purpose: ...
Tetramethylpyrazine attenuates the cancer stem cell like-properties and doxorubicin resistance by targeting HMGCR in breast cancer [0.03%]
Tetramethylpyrazine通过靶向HMGCR抑制乳腺癌干细胞样特性及阿霉素耐药性
Xuan Jiang,Manli Wang,Guoliang Cui et al.
Xuan Jiang et al.
Background: Tetramethylpyrazine (TMP), a key bioactive constituent derived from Ligusticum wallichii Franchat, has demonstrated efficacy in mitigating multidrug resistance (MDR) in human breast cancer (BC) cells. However,...
Curcumin reverses high-level tigecycline resistance mediated by different mechanisms in Gram-negative bacteria [0.03%]
姜黄素逆转革兰氏阴性菌不同机制介导的高水平替加环素耐药性
Mengxiang Zheng,Xiaoying Wu,Yakun Xu et al.
Mengxiang Zheng et al.
Background: Tigecycline is one of the few effective treatments for multidrug-resistant bacteria. However, the recent emergence and spread of high-level tigecycline resistance in Enterobacteriaceae have significantly limit...
Metagenomics and metabolomics to investigate the effect of Amygdalus mongolica oil on intestinal microbiota and serum metabolites in rats [0.03%]
基于胡桃油对大鼠肠道菌群及血清代谢物影响的元基因组学和代谢组学研究
Run-Xi Wang,Hong-Bing Zhou,Jia-Xing Gao et al.
Run-Xi Wang et al.
Background: Renal fibrosis (RF) is an inevitable consequence of multiple manifestations of progressive chronic kidney diseases (CKDs). Mechanism of Amygdalus mongolica (Maxim.) in the treatment of RF needs further investi...
Chuanxiong Qingnao Granules (CQG) alleviates nitroglycerin-induced migraine-like pain in rats by glycerophospholipid metabolism and PI3K/Akt signaling pathway [0.03%]
川芎清脑颗粒通过甘油磷脂代谢和PI3K/Akt信号通路缓解硝酸甘油诱发的偏头痛样痛疼
Jing-Yi Hou,Li-Han Wang,Li-Qi Ni et al.
Jing-Yi Hou et al.
Background and purpose: Chuanxiong Qingnao Granles (CQG), has been used to treat migraine headache (MH) for many years. However, current investigation of CQG have primarily focused on clinical studies, and the potential m...
Liquidambaric acid inhibits cholangiocarcinoma progression by disrupting the STAMBPL1/NRF2 positive feedback loop [0.03%]
液胺酸通过破坏STAMBPL1/NRF2正反馈环抑制胆管癌进展
Zhihuai Wang,Yinjie Zhang,Yuhang Shen et al.
Zhihuai Wang et al.
Background: Abnormal antioxidant capacity in cancer cells is intimately linked to tumor aggressiveness. Modulating oxidative stress status and inhibiting ferroptosis represents a novel anticancer therapeutic strategy. STA...
Unveiling the hepatoprotective mechanisms of Desmodium heterocarpon (L.) DC: Novel flavonoid identification and Keap1/Nrf2 pathway activation [0.03%]
Desmodium heterocarpon (L.) DC的肝保护机制研究：新型黄酮类成分鉴定及Keap1/Nrf2通路激活作用
XingNa Pu,Cheng Lu,Xing Yang et al.
XingNa Pu et al.
Background: The pathophysiology of liver diseases is significantly influenced by oxidative stress, making its alleviation a key strategy for treatment. The Keap1/Nrf2 signaling pathway is the body's most crucial antioxida...
Downregulation of cardiac inflammation via the CaMKII δ/NF-κB pathway in heart failure by Lonicerae Japonicae Flos and Angelicae Sinensis Radix [0.03%]
忍冬花与当归配伍通过钙调神经磷酸酶δ/NF-κB信号通路下调心衰心脏炎症的分子机制研究
Jiayang Tang,Xiang Li,Xue Yu et al.
Jiayang Tang et al.
Background: Inflammation serves an essential function in the occurrence and progression of heart failure (HF), especially in the early stage. Lonicerae japonicae Flos (LJF), Angelicae sinensis Radix (ASR), and their compa...
M13, an anthraquinone compound isolated from Morinda officinalis alleviates the progression of the osteoarthritis via the regulation of STAT3 [0.03%]
来源于Morinda officinalis的蒽醌类化合物M13通过调节STAT3缓解骨关节炎进展
Baolin Zhang,Ya Xiao,Deying Su et al.
Baolin Zhang et al.
Background: Osteoarthritis (OA) is characterized by the progressive deterioration of articular cartilage, leading to joint pain and functional impairment. OA severely impacts quality of life and presents a substantial soc...