Punicalagin inhibits excessive autophagy and improves cerebral function in neonatal rats with hypoxia-ischemia brain injury by regulating AKT-FOXO4 [0.03%]
punicalagin通过调节AKT-FOXO4抑制过度自噬并改善缺氧缺血性脑损伤的新生大鼠的脑功能
Ming Shen,Junhong Lu,Caiyan Li et al.
Ming Shen et al.
Background: Neonatal hypoxic-ischemic encephalopathy (HIE) has a high incidence and mortality rate, representing a significant patient burden. Therefore, treatment strategies that work synergistically with hypothermic the...
Effect of Tanreqing injection on multidrug resistance organisms: A test-negative case-control study and network pharmacology analysis [0.03%]
痰热清注射液对多重耐药菌的体外作用及网络药理学分析
Wen Wang,Jiayue Xu,Qinhuai Lai et al.
Wen Wang et al.
Background: Multidrug resistance organisms (MDROs) pose a major threat in intensive care units (ICUs). Although in vitro studies suggested that Tanreqing (TRQ) was effective against MDROs, evidence about TRQ injection usa...
Recent advances in phytocompounds as potential Chikungunya virus non-structural protein 2 protease antagonists: A systematic review [0.03%]
植物化合物作为潜在的基孔肯雅热病毒非结构蛋白2蛋白酶拮抗剂的最新进展：系统性综述
Jarmani Dansana,Priyanka Purohit,Madhusmita Panda et al.
Jarmani Dansana et al.
Background: The mosquito-borne pathogenic alphavirus known as Chikungunya virus (CHIKV) is becoming a greater hazard to public health, which causes thousands of cases annually in both rural and urban areas of many differe...
Exploring the mechanism and effective compounds of Changan Granule on diarrhea-predominant irritable bowel syndrome via regulating 5-hydroxytryptamine signaling pathway in brain-gut axis [0.03%]
基于脑-肠轴5-羟色胺信号转导通路探讨长安颗粒治疗腹泻型肠易激综合征的机制及有效成分研究
Qiaoxia Wang,Xiaoxuan Liu,Dongxing Song et al.
Qiaoxia Wang et al.
Background: Changan Granule (CAG) is a drug product developed from a traditional Chinese medicine (TCM) empirical prescription for diarrhea-predominant irritable bowel syndrome (IBS-D). The action mechanism and effective ...
Sang-Bai-Pi extract and its constituent regiafuran C ameliorate renal fibrosis through TGF-β/Smad and Wnt/β-catenin signaling pathways [0.03%]
桑白皮提取物及其成分雷公藤内酯甲通过TGF-β/Smad和Wnt/β-catenin信号通路改善肾纤维化
Quan-Hao Wei,Yin-Bo Pan,Lin-Lin Tian et al.
Quan-Hao Wei et al.
Background: Renal fibrosis is a major pathological feature of many chronic kidney diseases, and traditional Chinese medicines (TCM) have shown promising therapeutic potential for treating renal fibrosis. Although the extr...
MGB probe-based multiplex droplet digital PCR for the interspecific identification of Notopterygii Rhizoma et Radix in herbal materials and preparations [0.03%]
基于MGB探针的多重微滴数字PCR技术在中草药及制剂中独活和毛 ?>
Kai-Ling Xu,Zhong-Mou Zhang,Ya-Dan Wang et al.
Kai-Ling Xu et al.
Background: Owing to high sensitivity and ability for absolute quantification, the droplet digital polymerase chain reaction (ddPCR) is widely used for viral and bacterial detection. However, few studies have been conduct...
β-Triketones from Leptospermum scoparium (mānuka) oil show potential as scabicides [0.03%]
莱义油中的β-三酮类成分对治疗疥疮具有潜在活性
Nirupama A Nammunige,Kylie A Agnew-Francis,Deepani D Fernando et al.
Nirupama A Nammunige et al.
Background: Scabies is a debilitating and neglected infectious disease with limited effective treatment options and affecting millions of people worldwide, mainly in poor and overcrowded settings. Essential oils from Aust...
Decoding the role of SLC25A5 in osteosarcoma drug resistance and CD8+ T cell exhaustion: The therapeutic potential of phyllanthin [0.03%]
SLC25A5在骨肉瘤耐药及CD8+T细胞耗竭中的作用及青蒿素类药物治疗潜力研究
Ning Tang,Woding Deng,Yupeng Wu et al.
Ning Tang et al.
Osteosarcoma is an aggressive malignant bone tumor with an obscure etiology, as well as high prevalence and poor prognosis in children and adolescents. We aimed to investigate the pathogenesis of osteosarcoma through a comprehensive analysi...
Natural products as Nrf2 modulators for ferroptosis inhibition in renal disease therapy: Recent progress and future prospects [0.03%]
天然产物作为 NRF2 调节剂抑制肾病铁死亡的最新研究进展及未来前景
Ruimin Tian,Shan Guo,Shudong Chen et al.
Ruimin Tian et al.
Background: The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2, NFE2L2) is a pivotal regulator of redox balance, metabolism, protein homeostasis and inflammation. Nrf2 is critically involved in bot...
Mechanism of Fangji Huangqi decoction against acute kidney injury based on network pharmacology and experimental validation [0.03%]
基于网络药理学和实验验证的防己黄芪汤防治急性肾损伤的作用机制研究
Chengcheng Xiao,Yayun Wang,Jingwei Liu et al.
Chengcheng Xiao et al.
Background: Fangji Huangqi Decoction (FJHQD), a famous Traditional Chinese Medicine (TCM) formula, has been widely applied in improving renal function. However, the interaction of bioactives from FJHQD with the targets in...