Shenghui decoction inhibits neuronal cell apoptosis to improve Alzheimer's disease through the PDE4B/cAMP/CREB signaling pathway [0.03%]
盛慧汤通过PDE4B/cAMP/CREB信号通路抑制神经元细胞凋亡改善阿尔茨海默病功效的研究
Gai Gao,Xiaowei Zhang,Zhenghao Cui et al.
Gai Gao et al.
Background: Shenghui Decoction (SHD) is a frequently utilized traditional Chinese medicine formula in clinical settings for addressing cognitive impairment in elderly individuals. Nevertheless, the precise mechanism by wh...
Synergistic antimicrobial efficacy of glabrol and colistin through micelle-based co-delivery against multidrug-resistant bacterial pathogens [0.03%]
通过胶束共递送提高没药醇和多粘菌素对抗多重耐药细菌的协同抗菌效果
Ying Liu,Mengying Zhang,Yawei Cai et al.
Ying Liu et al.
Background: Widespread bacterial infection and the spread of multidrug resistance (MDR) exhibit increasing threats to the public and thus require new antibacterial strategies. Coupled with the current slow pace of antibio...
GelMA@APPA microspheres promote chondrocyte regeneration and alleviate osteoarthritis via Fgfr2 activation [0.03%]
凝胶明胶微球通过激活Fgfr2促进软骨细胞再生和缓解骨关节炎
Jiakai Wang,Tao Sun,Rong Zhang et al.
Jiakai Wang et al.
Background: In the context of osteoarthritis (OA), a condition marked by joint degeneration, there is a notable absence of efficacious approaches to promote regenerative healing in chondrocytes. Novel therapeutic strategi...
Ginkgo biloba extract EGb 761® ameliorates cognitive impairment and alleviates TNFα response in 5xFAD Alzheimer's disease model mice [0.03%]
银杏叶提取物EGb 761改善5XFAD阿尔茨海默病模型小鼠认知障碍并缓解TNFα反应
Vu Thu Thuy Nguyen,Robert Subirana Slotos,Malena Dos Santos Guilherme et al.
Vu Thu Thuy Nguyen et al.
Background: Ginkgo biloba leaf extract EGb 761® has shown clinical efficacy in patients with mild cognitive impairment and dementia. However, the pharmacological action of EGb 761® in Alzheimer's disease (AD) remains un...
Citrus aurantium 'Changshan-huyou' physiological premature fruit drop: A promising prebiotic to tackle obesity [0.03%]
芸香柑橘“changshan-huyou”生理前期落果：一种有望应对肥胖的益生元
Chao Wang,Mingfang Peng,Zhipeng Gao et al.
Chao Wang et al.
Background: Presently, the mitigation and governance of obesity have surfaced as significant public health dilemmas on a global scale. A wealth of studies indicated that the host gut microbiota is instrumental in regulati...
Yu-Xue-Bi capsule ameliorates aggressive synovitis and joint damage in rheumatoid arthritis via modulating the SUCNR1/HIF-1α/TRPV1 axis [0.03%]
愈血痹胶囊通过调节SUCNR1/HIF-1α/TRPV1轴改善类风湿性关节炎的侵袭性滑膜炎和关节损害
Wenjia Chen,Chu Zhang,Mingzhu Xu et al.
Wenjia Chen et al.
Background: Specific treatment for rheumatoid arthritis (RA) is still an unmet need. Yu-Xue-Bi (YXB) capsule effectively treats RA with blood stasis syndrome (BS). However, its mechanism remains unclear. ...
Na+-K+-ATPase/GLT-1 interaction participates in EGCG protection against cerebral ischemia-reperfusion injury in rats [0.03%]
EGCG通过Na+-K+-ATPase/GLT-1相互作用参与对大鼠脑缺血再灌注损伤的保护作用
Xin-Xin Liu,Xue-Ying Ke,Chen Jiang et al.
Xin-Xin Liu et al.
Background: In China, stroke is the primary cause of adult death and disability. Because of the increased rate of blood vessel reperfusion, it is important to prevent cerebral ischemia-reperfusion injury, in which glutama...
Metabolite profiling of Artemisia afra and Artemisia annua extracts reveals divergent effects on Plasmodium falciparum [0.03%]
有效成分 profiling 分析发现艾纳菊和黄花蒿提取物对恶性疟原虫具有不同的作用
Lucia Mamede,Gabriel W Rangel,Lahngong Methodius Shinyuy et al.
Lucia Mamede et al.
Background: Artemisia spp. have been used for millennia in traditional medicine to treat a variety of ailments, including malaria. Extracts of Artemisia afra and A. annua remain widely used throughout Africa for healthcar...
Perillaldehyde pretreatment alleviates cerebral ischemia-reperfusion injury by improving mitochondrial structure and function via the Nrf2/Keap1/Trx2 axis [0.03%]
细辛脑通过Nrf2/Keap1/Trx2轴改善线粒体结构和功能缓解缺血再灌注导致的脑损伤
Ji Liu,Ying Han,Zhiyun Wu et al.
Ji Liu et al.
Background: Perilladehyde, an extract of perillae in the Labiatae family, can produce significant anti-inflammatory and antioxidant effects. Although literature evidences the favorable effect of perillaldehyde on ischemic...
Enterolactone combined with m6A Reader IGF2BP3 inhibits malignant angiogenesis and disease progression in ovarian cancer [0.03%]
肠内乳酮联合m6A阅读蛋白IGF2BP3抑制卵巢癌恶性血管生成及疾病进展
Mengzhi Xu,Yi Guo,Fengge Wang et al.
Mengzhi Xu et al.
Background: Among all gynecological cancers, ovarian cancer is the leading cause of death. Epithelial ovarian cancer (EOC) accounts for over 85 % of ovarian cancer cases and is characterized by insidious onset, early meta...