Stigmasterol from Prunella vulgaris L. Alleviates LPS-induced mammary gland injury by inhibiting inflammation and ferroptosis [0.03%]
匍匐委陵菜中获得的 stigma-sterol通过抑制炎症和铁死亡缓解LPS诱导的小鼠乳腺损伤
Mingyang Sun,Dianwen Xu,Dianfeng Liu et al.
Mingyang Sun et al.
Background: Dairy mastitis, a prevalent condition affecting dairy cattle, represents a significant challenge to both animal welfare and the quality of dairy products. However, current treatment options remain limited. Sti...
Yiqi Huayu Jiedu formula inhibits JAK2/STAT3-mediated partial EMT in treating chronic atrophic gastritis [0.03%]
一奇花茹解毒方通过抑制JAK2/STAT3介导的上皮间质转化治疗慢性萎缩性胃炎
Weifeng Yu,Shuni Chen,Xiuming Guan et al.
Weifeng Yu et al.
Background: Chronic atrophic gastritis (CAG) is a precursor to gastric cancer, a leading cause of cancer-related deaths worldwide. Despite current therapeutic strategies, preventing the transition from gastritis to cancer...
Effect of daphnetin, the coumarin derivative isolated from Daphne genus, on Helicobacter pylori adhesion to gastric epithelial cells [0.03%]
来自杜鹃属植物的香豆素衍生物大苞花素对Helicobacter pylori粘附于胃上皮细胞的影响
Genzhu Wang,Mengjie Wang,Jing Pang et al.
Genzhu Wang et al.
Background: Adherence of Helicobacter pylori to the surface of the gastric mucosa is the initial and crucial step for its survival and colonization in the harsh conditions of the stomach. We had previously demonstrated th...
4-hydroxybenzoic acid induces browning of white adipose tissue through the AMPK-DRP1 pathway in HFD-induced obese mice [0.03%]
对羟基苯甲酸通过AMPK-DRP1信号通路诱导高脂饮食小鼠白色脂肪组织褐变
Sang Hee Kim,Woo Yong Park,Gahee Song et al.
Sang Hee Kim et al.
Background: Beige adipocytes have physiological functions similar to brown adipocytes, which are available to increase energy expenditure through uncoupling protein 1 (UCP1) within mitochondria. Recently, many studies sho...
Integration of transcriptomics and metabolomics reveals the mechanism of Glycyrrhizae Radix Et Rhizoma extract inhibiting CCL5 in the treatment of acute pharyngitis [0.03%]
整合转录组学和代谢组学揭示甘草酸抑制CCL5治疗急性咽炎的机制
Xiaoxiao Han,Chengtao Sun,Huizhe Ding et al.
Xiaoxiao Han et al.
Background: Acute pharyngitis (AP) is a common condition marked by inflammation of the oropharynx, which can lead to severe throat swelling, breathing difficulties, and even suffocation, significantly impacting quality of...
Celastrol ameliorates fibrosis in Western diet/tetrachloromethane-induced nonalcoholic steatohepatitis by suppressing Notch/osteopontin signaling [0.03%]
雷公藤红素通过抑制诺特定权信号改善西方饮食四氯化碳诱导的非酒精性steatohepatitis纤维化
Dingwu Li,Jianing Chen,Chenhui Ye et al.
Dingwu Li et al.
Background: Celastrol was recently identified as a potential treatment for obesity and hepatic steatosis. However, whether Celastrol effectively suppresses the nonalcoholic fatty liver disease (NAFLD) stage remains unknow...
mTOR/HIF-1α pathway-mediated glucose reprogramming and macrophage polarization by Sini decoction plus ginseng soup in ALF [0.03%]
四逆汤合参附汤通过mTOR/HIF-1α信号通路介导糖酵解重塑及M2型巨噬细胞极化改善急性肝 failure
Junli Zhang,Liyuan Hao,Shenghao Li et al.
Junli Zhang et al.
Background: Acute liver failure (ALF) has a high mortality rate, and despite treatment advancements, long-term outcomes remain poor. Purpose: ...
Melittin suppresses ovarian cancer growth by regulating SREBP1-mediated lipid metabolism [0.03%]
蜂毒肽通过调节SREBP1介导的脂质代谢抑制卵巢癌生长
Ruixin Wu,Ning Li,Weiling Huang et al.
Ruixin Wu et al.
Background: Melittin, a major peptide component of bee venom, has demonstrated promising anti-cancer activity across various preclinical cell models, making it a potential candidate for cancer therapy. However, its molecu...
Investigating the interaction between calcium signaling and ferroptosis for novel cancer treatment [0.03%]
探究钙信号与铁死亡的相互作用以寻求新的癌症治疗方法
Hao-Xin Yan,Yi-Zhong Zhang,Yu-Qing Niu et al.
Hao-Xin Yan et al.
Background: Drug resistance in cancer is steadily rising, making the development of new therapeutic targets increasingly critical for improving treatment outcomes. ...
Intervention effects of Er Miao san on metabolic syndrome in Bama miniature pigs [0.03%]
二妙散对巴马小型猪代谢综合征的干预效应
Rong Chen,Jianchi Lun,Tianze Wang et al.
Rong Chen et al.
Background: Metabolic syndrome (MS) refers to a cluster of metabolic disorders characterized by systemic chronic inflammation. Er Miao San (EMS) is a classic traditional Chinese medicine compound containing Phellodendron ...