SQYC formula improves the efficacy of PD-1 monoclonal antibodies in MSS colorectal cancer by regulating dendritic cell mitophagy via the PINK1-Parkin pathway [0.03%]
SQYC公式通过PINK1-Parkin途径调节树突状细胞线粒体自噬来提高PD-1单克隆抗体在MSS结直肠癌中的疗效
Hong Wang,Yi Ji,Shan Deng et al.
Hong Wang et al.
Background: Microsatellite stable (MSS) colorectal carcinomas (CRCs) exhibit poor responsiveness to immunotherapy such as immune checkpoint inhibitors (ICIs). In the realm of clinical cancer treatment, traditional Chinese...
Polydatin mitigates thrombosis by inhibiting PHD2-induced proline hydroxylation on collagen, reducing platelet adhesion [0.03%]
聚_datin_通过抑制_PHD2_诱导的胶原蛋白脯氨酸羟基化来减轻血栓形成并减少血小板粘附
Kaixin Liu,Chuanjing Cheng,Jin Yan et al.
Kaixin Liu et al.
Background: Platelet adhesion to collagen, a critical initial step in thrombus formation, remains an underexplored therapeutic target in thrombosis. Current disease treatment strategies primarily focus on platelet activat...
Paeoniflorin protects the vascular endothelial barrier in mice with sepsis by activating RXRα signaling [0.03%]
芍药苷通过激活RXRα信号保护脓毒症小鼠血管内皮屏障功能
Xinyue Cao,Ruihua Ma,Yirui Wang et al.
Xinyue Cao et al.
Objective: Sepsis is a life-threatening condition characterized by organ dysfunction resulting from the body's aberrant response to infection. A primary indicator of early sepsis is vascular leakage due to endothelial inj...
Anti-colorectal cancer actions of Glycyrrhiza uralensis Fisch. and its underlying mechanism via HPLC integration and network pharmacological approaches [0.03%]
基于HPLC整合及网络药理学方法的甘草抗结直肠癌作用及其机制研究
Hong Duan,Wei Wang,Ying Shi et al.
Hong Duan et al.
Background: The therapeutic and prognostic outcomes for colorectal cancer (CRC) remain unsatisfactory. Among multiple reported bioactive functionalities of Glycyrrhiza uralensis Fisch. one vital recently reported activity...
Protective effect of puerarin in diabetic nephropathy: A systematic review and meta-analysis of animal studies [0.03%]
地菍素防治糖尿病肾病的系统评价和Meta分析
Xiaoying Xu,Siqi Shen,Yingying Dong et al.
Xiaoying Xu et al.
Background: Puerarin is a crucial constituent separated from the Chinese herbaceous plant, Pueraria lobata (Willd.) Ohwi, which exhibits multiple biological activities. Previous studies have indicated that puerarin has a ...
Danshensu enhances autophagy and reduces inflammation by downregulating TNF-α to inhibit the NF-κB signaling pathway in ischemic flaps [0.03%]
丹参素通过下调TNF-α抑制NF-κB信号通路增强缺血皮瓣自噬及抗炎作用
Yingying Huang,Yingying Lai,Liang Chen et al.
Yingying Huang et al.
Background: The significant distal necrosis of the random-pattern skin flaps greatly restricts their clinical applications in flap transplantation. Previous studies have demonstrated the potential of danshensu (DSS) to al...
1,8-Cineole reduces pulmonary vascular remodelling in pulmonary arterial hypertension by restoring intercellular communication and inhibiting angiogenesis [0.03%]
1,8- cineole通过恢复细胞间通讯和抑制血管生成来减少肺动脉高压中的肺血管重塑
Jorge M Alves-Silva,Mónica Zuzarte,Carla Marques et al.
Jorge M Alves-Silva et al.
Background: Pulmonary Arterial Hypertension (PAH) is characterized by pulmonary vascular remodelling, often associated with disruption of BMPR2/Smad1/5 and BMPR2/PPAR-γ signalling pathways that ultimately lead to right v...
Oral administration of Folium Artemisiae Argyi-derived exosome-like nanovesicles can improve ulcerative colitis by regulating intestinal microorganisms [0.03%]
口服艾叶来源外泌体类似纳米囊泡可通过调节肠道菌群改善溃疡性结肠炎
Yishu Li,Su Shao,Yuanhao Zhou et al.
Yishu Li et al.
Background: Ulcerative colitis (UC), an inflammatory disease characterized by intestinal barrier dysfunction, poses significant challenges because of the toxicity and adverse effects commonly associated with conventional ...
The ethanolic extract of Rhaphidophora peepla prevents inflammation by inhibiting the activation of Syk/AKT/NF-κB and TAK1/MAPK/AP-1 [0.03%]
Rhaphidophora peepla乙醇提取物通过抑制Syk / AKT / NF- κB和TAK1 / MAPK / AP-1的活化来预防炎症作用
Yuhao Wang,Canglang Mou,Lei Huang et al.
Yuhao Wang et al.
Background: Inflammation is the body's innate reaction to foreign pathogens and serves as a self-regulating mechanism. However, the immune system can mistakenly target the body's own tissues, triggering unnecessary inflam...
Schisandrol B alleviates depression-like behavior in mice by regulating bile acid homeostasis in the brain-liver-gut axis via the pregnane X receptor [0.03%]
五味子醇B通过孕烷X受体调节脑-肝-肠轴胆汁酸稳态缓解小鼠抑郁样行为
Peng Wang,Hui Ouyang,Guofang Bi et al.
Peng Wang et al.
Background: Depression is a widely recognized neuropsychiatric disorder. Recent studies have shown a potential correlation between bile acid disorders and depression, highlighting the importance of maintaining bile acid b...