Syringin inhibits the crosstalk between macrophages and fibroblast-like synoviocytes to treat rheumatoid arthritis via PDE4 [0.03%]
丝绞酚通过PDE4抑制滑膜成纤维细胞与巨噬细胞的相互作用治疗类风湿性关节炎
Shan Cong,Ning Wang,Huan Pei et al.
Shan Cong et al.
Background: Syringin (SRG) is well-known for its anti-inflammatory effects. However, its pharmacological mechanisms against rheumatoid arthritis (RA) are not fully understood. ...
Regulation of inflammatory responses: Harnessing the Ruan Mai Jian targeting of EphA2/ephrinA1 pathway to enhance atherosclerosis amelioration [0.03%]
炎症反应的调节：利用瑞迈健调控EphA2/ephrinA1信号通路改善动脉粥样硬化研究进展
Xue Zhao,Hanyu Zhang,Jiayi Wang et al.
Xue Zhao et al.
Background: Atherosclerosis is a major contributor to global cardiovascular morbidity and mortality, driven by the chronic inflammatory proliferation of vascular smooth muscle cells (VSMCs), which destabilizes atheroscler...
Quercetin inhibits platelet activation and ER-stress mediated autophagy in response to extracellular histone [0.03%]
檞皮素通过抑制细胞外组蛋白诱导的血小板活化及内质网应激介导的自噬发挥炎性损伤防护作用
Kurnegala Manikanta,Somanathapura K NaveenKumar,Mahadevappa Hemshekhar et al.
Kurnegala Manikanta et al.
Background: Cellular histones are DNA-binding nuclear proteins involved in chromatin remodelling and regulation of gene expression. However, extracellular histones act as damage-associated molecular patterns (DAMPs) and c...
Insights into Q-marker of Shensong Yangxin capsule in treating cardiac arrhythmias based on a linear substitution strategy in quantification of multiple components [0.03%]
基于多组分线性替换策略定量的参松养心胶囊治窦缓型心律失常物质基础探究
Zi-Ting Li,Peng-Cheng Zhao,Xiao-Xing Wang et al.
Zi-Ting Li et al.
Background: The concept of a Quality marker (Q-marker) has emerged as a crucial tool for ensuring the safety and efficacy of Traditional Chinese Medicine (TCM) formulas. However, significant challenges remained in the ide...
Puerarin mitigates cognitive decline and white matter injury via CD36-Mediated microglial phagocytosis in chronic cerebral hypoperfusion [0.03%]
葛根素通过CD36介导的小胶质细胞吞噬作用缓解慢性脑低灌注大鼠认知障碍和白质损伤
Qinghua Luo,Fang Li,Xu Liu et al.
Qinghua Luo et al.
Background: Chronic cerebral hypoperfusion (CCH) contributes significantly to white matter injury (WMI) and cognitive impairment, often leading to vascular dementia (VaD). Inefficient clearance of myelin debris by microgl...
Oxymatrine alleviates ALD-induced cardiac hypertrophy by regulating autophagy via activation Nrf2/SIRT3 signaling pathway [0.03%]
氧化.matrine通过激活Nrf2/SIRT3信号通路调节自噬从而缓解酒精性心肌病诱导的肥大
Dingchun Lu,Shun Wu,Xueting Wang et al.
Dingchun Lu et al.
Background: Cardiac hypertrophy is a prevalent early pathological manifestation in various cardiovascular diseases, lacking effective interventions to impede its progression. Although oxymatrine (OMT) has shown potential ...
Redox imbalance driven epigenetic reprogramming and cardiovascular dysfunctions: phytocompounds for prospective epidrugs [0.03%]
红氧平衡驱动的表观重编程与心血管功能障碍：植物化合物作为潜在表观药物的前景
Subham Saraswata Jyotirmaya,Suvasmita Rath,Jagneshwar Dandapat
Subham Saraswata Jyotirmaya
Background: Cardiovascular diseases (CVDs) are the major contributor to global mortality and are gaining incremental attention following the COVID-19 outbreak. Epigenetic events such as DNA methylation, histone modificati...
Picrosides-rich fraction from Picrorhiza kurroa attenuates steatohepatitis in zebrafish and mice by modulating lipid metabolism and inflammation [0.03%]
_picrorhiza kurroa_ 中富含 picrosides 的组分通过调节脂质代谢和炎症来缓解斑马鱼和小鼠的steatohepatitis
Swati Katoch,Jyoti Chhimwal,Damanpreet Singh et al.
Swati Katoch et al.
Background: Non-alcoholic steatohepatitis (NASH) has become a serious public health concern with high global prevalence. The lack of safe and efficient treatment for the condition demands exploring new therapeutic solutio...
Yangyin Yiqi Huoxue Decoction improves the mechanism of microglia activation against CIS-induced neuroinflammatory injury by regulating the Wnt signaling pathway [0.03%]
养阴益气活血汤通过调节Wnt信号通路改善环磷酰胺所致中枢神经炎症损伤小胶质细胞激活机制
Ting Lu,Ying Huang,Jiehong Yang et al.
Ting Lu et al.
Background: Ischemic stroke is a predominant cause of neurological disability, characterized by neuroinflammation and neuronal apoptosis. The Wnt signaling pathway plays a critical role in brain repair. Yangyin Yiqi Huoxu...
Natural products target pyroptosis for ameliorating neuroinflammation: A novel antidepressant strategy [0.03%]
天然产物靶向细胞炎性焦亡改善神经炎症：一种新型的抗抑郁策略
Guangheng Zhang,Ruirui Shang,Xia Zhong et al.
Guangheng Zhang et al.
Background: Depression is a common mental disorder characterized by prolonged loss of interest and low mood, accompanied by symptoms such as sleep disturbances and cognitive impairments. In severe cases, there may be a te...