Anti-inflammatory activity of essential oil from medicinal plants: An insight into molecular mechanism, in-silico studies and signaling pathways [0.03%]
药用植物精油的抗炎活性：分子机制、计算机模拟研究和信号通路的见解
Lopamudra Subudhi,Hrudayanath Thatoi,Amrita Banerjee
Lopamudra Subudhi
Background: Medicinal plants have historically been the cornerstone of treatment for a myriad of ailments. With modern pharmacology, many contemporary drugs have been derived from traditional medicine practices. Essential...
Integrated metabolomics and mass spectrometry imaging analysis reveal the efficacy and mechanism of Huangkui capsule on type 2 diabetic nephropathy [0.03%]
整合代谢组学和质谱成像分析揭示黄葵胶囊治疗2型糖尿病肾病的疗效及机制
Jinwei Han,Ping Li,Hui Sun et al.
Jinwei Han et al.
Background: Huangkui capsule (HKC), a Chinese patent medicine, is clinically used for treating diabetic nephropathy. However, the core disease-specific biomarkers and targets of type 2 diabetic nephropathy (T2DN) and the ...
Formosanin C induces autophagy-mediated cell death in hepatocellular carcinoma through activating DUSP1/AMPK/ULK1/Beclin1 signaling pathway [0.03%]
Formosanin C通过激活DUSP1/AMPK/ULK1/Beclin1信号通路诱导自噬介导的肝癌细胞死亡
Zhikai Wen,Jinxia Qi,Qingqing Ruan et al.
Zhikai Wen et al.
Background: Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is associated with poor survival. Formosanin C (FC) is a diosgenin glycoside extracted from Paris polyphylla. Therapeutic e...
Qige Decoction attenuated non-alcoholic fatty liver disease through regulating SIRT6-PPARα-mediated fatty acid oxidation [0.03%]
歧格汤通过上调SIRT6-PPARα介导的脂肪酸氧化改善非酒精性脂肪肝病
Simin Fan,Wei Chen,Yanfang Li et al.
Simin Fan et al.
Background: Sirtuin 6 (SIRT6), a potential therapeutic target for non-alcoholic fatty liver disease (NAFLD), has been shown to regulate fatty acid oxidation (FAO) by interacting with peroxisome proliferator-activated rece...
Tiaogeng decoction improves mild cognitive impairment in menopausal APP/PS1 mice through the ERs/NF-κ b/AQP1 signaling pathway [0.03%]
调经汤通过雌激素受体/NF-κB/AQP1信号通路改善APP/PS1绝经过渡期小鼠轻度认知障碍
Xuan-Ling Li,Zhi-Heng Lin,Si-Ru Chen et al.
Xuan-Ling Li et al.
People with mild cognitive impairment (MCI) carry a considerable risk of developing dementia. Studies have shown that female sex hormones have long-lasting neuroprotective and anti-aging properties, and the increased risk of MCI and AD is a...
Shouhui Tongbian Capsule ameliorates obesity by enhancing energy consumption and promoting lipolysis via cAMP-PKA pathway [0.03%]
舒肝解郁胶囊通过cAMP-PKA信号通路改善肥胖的机制研究：增加能量消耗和促进脂肪分解作用
Kaiyi Wu,Jiangying Kuang,Nana Huang et al.
Kaiyi Wu et al.
Background: The prevalence of obesity and its associated diseases has sharply increased, becoming a global health issue. White adipose tissue (WAT), responsible for lipid storage via hyperplasia and hypertrophy, and brown...
Astragaloside IV inhibits retinal pigment epithelial cell senescence and reduces IL-1β mRNA stability by targeting FTO-mediated m6A methylation [0.03%]
ASTAGALOSIDE Ⅳ通过靶向FTO介导的m6A甲基化抑制视网膜色素上皮细胞衰老并降低IL-1β mRNA稳定性
Si-Wei Wang,Ping Li,Shi-Yu Liu et al.
Si-Wei Wang et al.
Background: Resistance to senescence in retinal pigment epithelial (RPE) cells can delay the progression of age-related macular degeneration (AMD). However, the mechanisms underlying RPE cell senescence remain inadequatel...
Harnessing natural saponins: Advancements in mitochondrial dysfunction and therapeutic applications [0.03%]
利用天然皂苷在线粒体功能障碍及治疗应用方面的进展
Hongmei Liu,Huan Wang,Xinyu Lin et al.
Hongmei Liu et al.
Background: Mitochondrial dysfunction plays a crucial role in the development of a variety of diseases, notably neurodegenerative disorders, cardiovascular diseases, metabolic syndrome, and cancer. Natural saponins, which...
β-Sitosterol modulates osteogenic and adipogenic balance in BMSCs to suppress osteoporosis via regulating mTOR-IMP1-Adipoq axis [0.03%]
β-谷固醇通过调节mTOR-IMP1-Adipoq轴调控骨髓间充质干细胞成骨和成脂分化平衡从而抑制骨质疏松症
Hao Li,Ying Gong,Yanna Wang et al.
Hao Li et al.
Background: Osteoporosis (OP) is a prevalent global health concern, impacting millions of individuals, especially the elderly. The etiology of senile OP is associated with the imbalance of osteogenic and adipogenic differ...
Modified Shenqi Dihuang Decoction inhibits prostate cancer metastasis by disrupting TCA cycle energy metabolism via NF-kB/p65-mediated OGDH regulation [0.03%]
改写四君子汤通过NF-kB/p65介导的OGDH调节破坏TCA周期能量代谢抑制前列腺癌转移
Tongtong Zhang,Jixiang Yuan,Xiran Ju et al.
Tongtong Zhang et al.
Background: Prostate cancer (PCa) is a significant malignancy in men, particularly challenging in the metastatic stage due to poor prognosis and limited treatment efficacy. Traditional Chinese Medicine, particularly Modif...