Anti-resorptive dihydrophenanthrene coelonin alleviates arthritic bone destruction by inhibiting osteoclast formation and synovial inflammation through Src regulation [0.03%]
(src调控抑制破骨细胞形成和滑膜炎症抗吸收二氢菲类化合物秋水仙碱可缓解关节炎性骨破坏作用研究)
Yanbei Tu,Wendi Yue,Guiyu Dai et al.
Yanbei Tu et al.
Background: The overactivation of osteoclasts (OCs) and fibroblast-like synoviocytes (FLS) is a key contributor to the bone destruction associated with rheumatoid arthritis (RA). Coelonin (COE) is known as an anti-inflamm...
Mori fructus-derived extracellular vesicle-like nanoparticles regulate dyslipidemia and prevent atherosclerosis progression via miRNAs [0.03%]
莫里福克图斯衍生的外泌体类似纳米颗粒通过miRNA调节脂质异常并预防动脉粥样硬化进展
Yunchan Sui,Xiaoyu Sun,Qisijing Liu et al.
Yunchan Sui et al.
Background: Atherosclerosis, driven majorly by dyslipidemia, is a major risk factor for acute and chronic cardiovascular diseases. Hence, the development of bioactive products that can regulate lipid metabolism and preven...
Lianweng formula restores intestinal barrier function in ulcerative colitis through the β-arrestin 1/NF-κB signaling axis [0.03%]
连瘟汤通过β-arrestin 1/NF-κB信号轴修复溃疡性结肠炎肠道屏障功能
Jianyu Lv,Yuchen Fu,Sijuan Huang et al.
Jianyu Lv et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory disorder with a high incidence rate. UC has emerged as a significant global public health challenge mostly because of the limitations of current therapeutic st...
Parthenolide inhibits Hsp90α ATPase activity and overcomes acquired BRAF-inhibitor resistance in cutaneous melanoma [0.03%]
帕ทร诺龙抑制Hsp90αATP酶活性并克服皮肤黑色素瘤获得性BRAF耐药性
Xiao-Qi Wang,Xiao-Fei Yu,Amy Sze-Man Li et al.
Xiao-Qi Wang et al.
Background: Oncogenic mutations in the BRAF gene, particularly the V600E mutation, are present in roughly half of metastatic cutaneous melanoma cases. BRAF inhibitors (BRAFi) have shown significant clinical efficacy; howe...
Puerarin-rich compound Puerariae lobatae formulas alleviate hyperuricemia in mice by enhancing renal and intestinal function through regulating gut microbiota [0.03%]
富含葛根素的葛根汤剂通过调节肠道菌群改善小鼠肾肠功能从而降低血尿酸水平
Zhi-Xuan Li,Kai-Wen Kang,Hao Zheng et al.
Zhi-Xuan Li et al.
Background: Hyperuricemia, a metabolic disorder strongly associated with gout and cardiorenal diseases, has become a global health threat affecting over 15% of the worldwide population. Current pharmacotherapies face limi...
Harringtonine (HT) targets PARP-1 to inhibit TS mRNA m6A modification, blocks STAT3-induced miR-4521/TS axis and attenuates 5-fluorouracil (5-FU) resistance in NSCLC [0.03%]
Harringtonine通过靶向PARP-1抑制TS mRNA的m6A修饰，阻断STAT3诱导的miR-4521/TS轴并缓解5-氟尿嘧啶耐药性在非小细胞肺癌中的作用
Yu-Xi Qin,Yue-Ying Yang,Shi-Chen Zhang et al.
Yu-Xi Qin et al.
Background: Harringtonine (HT), derived from the genus Cephalotaxus, has demonstrated anti-proliferative effects against non-small cell lung cancer (NSCLC). 5-Fluorouracil (5-FU), a cost-effective chemotherapy, faces resi...
Qu-yu-jie-du decoction maintenance therapy improves postoperative survival in metastatic colorectal cancer: a single-center randomized trial with 36-month follow-up [0.03%]
气 Yu Jie Du 汤维持治疗改善转移性结直肠癌术后生存：一项单中心随机试验（随访 36 个月）
Jiaming Wu,Cui Shao,Yu Dong et al.
Jiaming Wu et al.
Background: Qu-yu-jie-du (QYJD) decoction is an established traditional Chinese medicine (TCM) formulation. For over ten years, there has been empirical evidence in support of its benefits for colorectal cancer patients, ...
Cis-resveratrol blocks crystal-induced NLRP3 inflammasome activation via the TRPV4-Ca²⁺-phagocytosis-ROS axis [0.03%]
白藜芦醇通过瞬时受体电位香草酸受体4-钙离子-吞噬作用-活性氧轴阻断晶体诱导的NLRP3炎性小体活化
Shuhui Lei,Kaiqun Liu,Cong Liu et al.
Shuhui Lei et al.
Background: Inflammation is a vital biological defense mechanism, yet uncontrolled or prolonged inflammation can cause tissue damage. The NLRP3 inflammasome, a central component of innate immunity, drives inflammation by ...
Huo Po Xia Ling decoction exerts preventive and improvement effects on gastric precancerous lesions by remodeling gut microbiota and associated metabolites [0.03%]
活朴下灵汤通过重塑肠道菌群及其相关代谢物对胃癌前病变具有预防和改善作用
Yanru Song,Yining Qiao,Shasha Gao et al.
Yanru Song et al.
Background: Huo Po Xia Ling Decoction (HPXLD) is a classical formulation in traditional Chinese medicine (TCM), and has demonstrated potential in managing gastric precancerous lesions (GPL). However, the mechanisms respon...
Luteolin Induces GPX4-dependent Ferroptosis and Enhances Immune Activation in Colon Cancer [0.03%]
黄酮类化合物黄芩素通过诱导GPX4依赖性铁死亡和免疫激活治疗结直肠癌
Qiaochang Cao,Siqi Ding,Xueer Zheng et al.
Qiaochang Cao et al.
Background: Ferroptosis is pivotal in colon cancer progression and immunity. While the natural flavonoid luteolin has anticancer properties, its ferroptosis targets and immunomodulatory effects in colon cancer are unclear...