Gallic acid: A promising anti-non-small cell lung cancer compound targeting early growth response protein-1 for apoptosis and ferroptosis [0.03%]
没食子酸通过靶向早期生长反应蛋白-1诱导非小细胞肺癌细胞凋亡和铁死亡的抗非小细胞肺癌作用研究
Bin-Bin Li,Jing-Tao Zhang,Yi-Yang Jiang et al.
Bin-Bin Li et al.
Background: Regulated cell death (RCD) is a therapeutic strategy for cancer treatment through the clearance of aberrant cells. Given the diversity of malignant tumors, relying on a single mode of RCD may prove difficult i...
Buyang Huanwu Decoction suppresses atherosclerosis by targeting IFITM1‑mediated lipid metabolism in vascular smooth muscle cells [0.03%]
补阳还五汤通过靶向血管平滑肌细胞中的IFITM1介导的脂质代谢抑制动脉粥样硬化
Qionghui Huang,Xiaoyan Tang,Qingyan Huang et al.
Qionghui Huang et al.
Background: The transformation of vascular smooth muscle cells (VSMCs) into foam cells is a pivotal event in atherosclerotic plaque formation during atherosclerosis. Although interferon-induced transmembrane protein 1 (IF...
Chlorella pyrenoidosa-derived extracellular vesicles ameliorate ulcerative colitis through microbiota-mediated AKT/mTOR/ferroptosis pathway [0.03%]
小球藻衍生的外泌体通过微生物群介导的AKT/mTOR/铁死亡通路改善溃疡性结肠炎
Danya Lu,Xi Chen,Demei Wang et al.
Danya Lu et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory disease characterized by frequent relapses and slow recovery, with a current deficiency in safe and effective therapeutic options. Chlorella pyrenoidosa (CP), ...
Sesamin ameliorates high-fat diet-induced inflammation and metabolic dysfunction in pregnant uterine smooth muscle via cGAS-STING inhibition [0.03%]
sesame素通过抑制cGAS-STING途径改善高脂饮食诱导的妊娠子宫平滑肌炎症和代谢功能障碍
Chenyi Xu,Xuan Li,Chen Yang et al.
Chenyi Xu et al.
Background: Maternal obesity and high-fat diets disrupt uterine metabolic homeostasis, leading to mitochondrial dysfunction, insulin resistance, and inflammation in uterine smooth muscle cells (USMCs), which may compromis...
Hyperoside accelerates myelin debris clearance by inhibiting signal transducer and activator of transcription 3 phosphorylation in peripheral nerve injury [0.03%]
hyperoside加速外周神经损伤后髓鞘脱屑清除的新机制：抑制STAT3磷酸化
Bang Su,Nan Wang,Xiaoping Xie et al.
Bang Su et al.
Background: Neuroinflammation resulting from myelin debris impedes axonal regeneration. Pharmacological modulation of myelin clearance and inflammatory responses is a potential strategy to enhance nerve regeneration. Hype...
Narciclasine alleviates zearalenone-induced focal adhesion damage and anoikis in rat Sertoli cells through PI3K signaling pathway [0.03%]
narcissine通过PI3K信号途径缓解焦耳附着损伤和zediranone诱导的无连接素在大鼠支持细胞中的凋亡
Peirong Cai,Nannan Feng,Hui Zou et al.
Peirong Cai et al.
Background: Zearalenone (ZEA), a widespread mycotoxin found in crops, is known to cause reproductive disorders in human and animals. Purpose: ...
Hongqi Shenmai Yin attenuates adverse cardiac remodeling following myocardial infarction via inhibition of STING-dependent PANoptosis [0.03%]
红芪饮通过抑制STING依赖性PANoptosis防治心肌梗死后心脏重构
Meng Zhang,Zhaoyang Chen,Xuehui Yin et al.
Meng Zhang et al.
Background: Pathological ventricular remodeling following myocardial infarction (MI) severely impacts long term prognosis of patients, yet effective interventions to halt its progression remain limited. Hongqi Shenmai Yin...
Enterolactone mitigates atherosclerosis by facilitating resolution of ferroptosis-associated intimal inflammation via the Keap1/Nrf2/GPX4 pathway [0.03%]
肠乳酸通过Keap1/Nrf2/GPX4途径促进铁死亡相关内膜炎症消退从而缓解动脉粥样硬化
Shuhui Chai,Yihang Zhang,Yi Guo et al.
Shuhui Chai et al.
Background: Atherosclerosis is the inflammatory consequence of lipid accumulation with plaque formation in the vascular intima and is a common condition to develop into various cardiovascular diseases. Current therapies d...
Gypenosides ameliorate depression by modulating microglial state transition via the NLRP3/Caspase-1/ASC signaling pathway [0.03%]
甘松素通过NLRP3/Caspase-1/凋亡相关斑点样蛋白信号通路调节小胶质细胞状态转换来改善抑郁症状
Mei Guo,Can Cui,Zhou-Juan Zheng et al.
Mei Guo et al.
Background: Depression remains a major global health challenge. Microglial polarization imbalance and subsequent neuroinflammation are core pathological mechanisms. Given current treatment limitations, developing natural ...
Wumei Wan alleviates intestinal fibrosis via the microbiota-metabolite-YAP-mechanotransduction axis [0.03%]
乌梅丸通过微生物群-代谢物-YAP-机械转导轴缓解肠纤维化
Mingjie Yang,Xinyue Zhang,Haibo Zhang et al.
Mingjie Yang et al.
Background: Intestinal fibrosis is a common complication of Crohn's disease, for which effective therapies remain lacking. Wumei Wan (WMW), a classical traditional Chinese medicine formula, has been used for nearly two mi...