Mechanism exploration of Wenshen Jianpi Decoction on renoprotection in diabetic nephropathy via transcriptomics and metabolomics [0.03%]
温肾健脾方通过转录组学和代谢组学探讨糖尿病肾病的保肾机制研究
Yingping Deng,Guanghui Zhong,Tinglong Jin et al.
Yingping Deng et al.
Background: Diabetic nephropathy (DN) is a severe chronic microvascular complications of diabetes mellitus and the leading cause of end-stage renal disease. Although many therapeutic approaches have been developed for tre...
Isovaleroylbinankadsurin A ameliorates atherosclerosis and restenosis by promoting LXRα signaling pathway and inhibiting TGF-β1 and FHL1 signaling pathways [0.03%]
异戊酰宾汉卡苏林A通过促进LXRα信号通路并抑制TGF-β1和FHL1信号通路改善动脉粥样硬化及再狭窄作用
Yaning Shi,Leping Liu,Yongzhen Gong et al.
Yaning Shi et al.
Background: Atherosclerosis is a leading factor in the development of several cardiovascular conditions, including ischemic heart disease, stroke, and peripheral vascular disease. A defining characteristic of atherosclero...
Shengjiang Xiexin Decoction ameliorates DSS-induced ulcerative colitis via activating Wnt/β-Catenin signaling to enhance epithelium renovation and modulating intestinal flora [0.03%]
芍药甘草汤通过激活Wnt/β-catenin信号通路促进上皮修复及调节肠道菌群改善DSS诱导的溃疡性结肠炎
Chen Chen,Xiao-He Lin,Yi-Min Xie et al.
Chen Chen et al.
Background: Shengjiang Xiexin Decoction (SJXXD) is a recognized formulation in traditional Chinese medicine that is commonly employed in diarrhea treatment. It has the potential to be a viable alternative for treating ulc...
Linarin attenuates hyperuricemic nephropathy by modulating Nrf2/Keap1 and TLR4/NF-κB signaling pathways: Linarin attenuates hyperuricemic nephropathy [0.03%]
芹菜素通过调节Nrf2/Keap1和TLR4/NF-κB信号途径缓解高尿酸性肾病：芹菜素缓解高尿酸性肾病
Yongshuai Qian,Yan Zhang,Yue Chen et al.
Yongshuai Qian et al.
Background: Hyperuricemia (HUA) can lead to hyperuricemic nephropathy (HN) as a result of prolonged uric acid (UA) supersaturation, primarily characterized by excessive inflammation and oxidative stress. In clinical pract...
Exploring the active components and potential mechanisms of Zhimu-Huangbai herb-pair in the treatment of depression [0.03%]
探讨知母与黄柏药对治疗抑郁症的活性成分及潜在机制
Xia Lei,Deping Zhao,Tongtong Chen et al.
Xia Lei et al.
Background: The Zhimu-Huangbai herb-pair (ZB) is commonly used to treat depression. Previous research has verified that ZB is effective as an antidepressant. Nevertheless, its active components and potential mechanism sti...
Unveiling polysaccharides of Houttuynia cordata Thunb.: Extraction, purification, structure, bioactivities, and structure-activity relationships [0.03%]
鱼腥草多糖研究进展：提取、纯化、结构、活性及构效关系
Shiyong Gao,Weiya Wang,Jianwen Li et al.
Shiyong Gao et al.
Background: Houttuynia cordata Thunb. is a plant valued for both its culinary and medicinal properties, utilized in the prevention and treatment of various ailments. Houttuynia cordata Thunb. polysaccharides (HCP) exhibit...
Proteomic analysis reveals QiShenYiQi Pills ameliorates ischemia-induced heart failure through inhibition of mitochondrial fission [0.03%]
蛋白组学分析揭示气阴双补胶囊通过抑制线粒体分裂改善缺血性心力衰竭
Jia Li,Xinyao Zhang,Liuqing Hou et al.
Jia Li et al.
Background: QiShenYiQi Pills (QSYQ) has widely used in clinical treatment of cardiovascular diseases; however, the exact mechanism behind its effectiveness still requires further investigation. ...
Hepatotoxicity of Phytolacca acinosa Roxb mediated by phytolaccagenin via ferroptosis/PPAR/P53/arachidonic acid metabolism [0.03%]
半边莲诱导肝脏毒性的机制研究：铁死亡/PPAR/P53途径及花生四烯酸代谢角度分析
Muyao Cui,Yao Zhang,Yang Tang et al.
Muyao Cui et al.
Background: The traditional Chinese medicine Phytolacca acinosa Roxb (PAR), known as Shanglu, possesses recognized therapeutic benefits against many diseases. PAR is also hepatotoxic, making it a major public health probl...
Targeting pyroptosis: A novel strategy of ginseng for the treatment of diabetes and its chronic complications [0.03%]
靶向细胞炎性焦亡：人参治疗糖尿病及其慢性并发症的新策略
Ke Li,Ya-Jun Wang,Chen Chen et al.
Ke Li et al.
Background: Pyroptosis is a recently identified form of programmed cell death that plays a crucial role in the pathogenesis and progression of diabetes and associated chronic complications, while the occurrence mechanism ...
Integrated identification and mechanism exploration of bioactive ingredients from Salvia miltiorrhiza to induce vascular normalization [0.03%]
基于综合识别和机制探索的丹参活性成分促血管正常化研究
Cheng Qian,Ying Huang,Shan Zhang et al.
Cheng Qian et al.
Background: The clinical management of ischemic disease and cancer is complex, with disruptions in local vascular function and tumor angiogenesis contributing to blood stasis, which complicates treatment strategies. Salvi...