Norwogonin attenuates LPS-induced acute lung injury through inhibiting Src/AKT1/NF-κB signaling pathway [0.03%]
Norwogonin通过抑制Src/AKT1/NF-κB信号转导途径缓解内毒素诱导的急性肺损伤
Tianjiao Cao,An-Qing Li,Yi Zhang et al.
Tianjiao Cao et al.
Background: Acute lung injury (ALI) has emerged as a critical illness, with sepsis-related ALI accounting for >80 %. In the context of bacterial infection, damage to the pulmonary microvascular barrier leads to inflammato...
6-C-methylquercetin in Baeckea frutescens exerts anti-prostate cancer effect via ErbB/PI3K/AKT pathway [0.03%]
光叶菍中的6-C-甲基槲皮素通过ErbB/PI3K/AKT途径发挥抗前列腺癌作用
Beixi Jia,Mengyao Zhang,Xinyue Jiang et al.
Beixi Jia et al.
Background: Prostate cancer (PCa) is one of the malignant tumors that seriously affect the health of middle-aged and older men. Chinese medicinal herbs have great potential in tumor therapy with less toxic side effects. 6...
Cycloastragenol targets Fpr2 to inhibit the TLR4/NF-κB signaling pathway and alleviate neuroinflammation in Parkinson's disease [0.03%]
环马兜铃酸基因 targeting Fpr2 抑制 TLR4/NF-κB 信号通路以缓解帕金森病神经炎症
Shengnan Xiao,Lianmei Liu,Xuemei Qin et al.
Shengnan Xiao et al.
Background: Parkinson's disease (PD) is a neurodegenerative disease, and neuroinflammation is an important factor in its pathogenesis. Therefore, improving neuroinflammation has become a key direction in PD research. Cycl...
Corrigendum to "Qiji Shujiang granules alleviates dopaminergic neuronal injury of parkinson's disease by inhibiting NLRP3/Caspase-1 pathway mediated pyroptosis" [Phytomedicine, 120, 2023, 155019] [0.03%]
关于“期颐寿浆颗粒通过抑制NLRP3/ caspase-1通路介导的细胞焦亡减轻帕金森病多巴胺能神经元损伤”一文的勘误[Phytomedicine, 120, 2023, 155019]
Pengfei Huan,Xue Sun,Zhuqing He et al.
Pengfei Huan et al.
Epimedin C promotes mitochondrial transfer and delays thymus atrophy in 4-VCD induced mimetic-menopausal mice [0.03%]
黄芩素C促进线粒体转移并延缓4-VCD诱导的类绝经期小鼠胸腺萎缩
Yuyuan Ying,Shiyu Hu,Yaoying Shu et al.
Yuyuan Ying et al.
Background: Prevention of thymus atrophy during menopause is of great significance for improving the immune function and overall health of menopausal women. Epimedin C is one of the major bioactive compounds in Herba Epim...
Elucidating the mechanism of the first Chinese herbal formula Shuangxia Decoction to alleviate insomnia using multi-omics technologies [0.03%]
运用多组学技术阐明首个中药安神方双下汤治疗失眠的机制
Runhua Liu,Hao Wu,Jianmin Zhang et al.
Runhua Liu et al.
Background: Shuangxia Decoction (SXD), evolved from " Banxia Shumi Decoction", is composed of Pinellia ternata (Thunb.) Makino and Prunella vulgarisl. SXD has been used to treat insomnia and is considered the first tradit...
Naturally-occurring carnosic acid as a promising therapeutic agent for skin inflammation via targeting STAT1 [0.03%]
靶向STAT1的天然护皮素作为治疗皮肤炎症的潜在药物
Aike Wu,Yunying Wang,Rui Mao et al.
Aike Wu et al.
Background: Psoriasis and rosacea are prevalent chronic inflammatory skin disorders driven by aberrant interactions between skin-resident keratinocytes and immune cells. Natural products represent a largely untapped sourc...
Polysaccharides from hawthorn fruit alleviate high-fat diet-induced NAFLD in mice by improving gut microbiota dysbiosis and hepatic metabolic disorder [0.03%]
山楂果实多糖通过改善肠道菌群紊乱和肝脏代谢障碍缓解小鼠高脂诱导的非酒精性脂肪肝病
Yuan Zhou,Mengyao Wang,Zichuan Wang et al.
Yuan Zhou et al.
Background: Hawthorn fruit, renowned as both a functional food and herbal medicine with lipid-lowering effects, is abundant in polysaccharides. However, there is limited research on the effects and mechanisms of hawthorn ...
Xin-Ji-Er-Kang balances mitochondrial fusion and fission to protect cardiomyocytes in mice with heart failure by regulating the ERα/SIRT3 pathway [0.03%]
雌激素通过调节ERα/SIRT3通路平衡线粒体动态以在心力衰竭小鼠中保护心肌细胞
Wei-Wei Cai,Yuan-Yuan Qin,Fei Ge et al.
Wei-Wei Cai et al.
Background: Mitochondrial dynamics imbalance is an essential pathological mechanism in heart failure (HF). The Chinese herbal formula Xin-Ji-Er-Kang (XJEK) has demonstrated good therapeutic effects in various cardiovascul...
Sanzi Yangqin Decoction improved acute lung injury by regulating the TLR2-mediated NF-κB/NLRP3 signaling pathway and inhibiting the activation of NLRP3 inflammasome [0.03%]
三子养亲汤通过调节TLR2介导的NF-κB/NLRP3信号途径抑制NLRP3炎性小体活化改善急性肺损伤
Anna Gan,Haimiao Chen,Fei Lin et al.
Anna Gan et al.
Background: Acute lung injury (ALI) is a serious respiratory ailment marked by dysregulation of the immune dysregulation and an inflammatory reaction.Currently, effective treatment options for ALI are limited. Sanzi Yangq...