Palmatine activation of TFEB enhances autophagy and alleviates endoplasmic reticulum stress in intervertebral disc degeneration [0.03%]
掌叶防己碱通过激活TFEB促进腰椎间盘退变的自噬诱导作用及内质网应激缓解作用
Heng Yu,Kaiye Chen,Xiang Li et al.
Heng Yu et al.
Background: Intervertebral disc degeneration (IDD) is integral in lower back pain and involves complex pathophysiological processes, including nucleus pulposus (NP) cell apoptosis and extracellular matrix (ECM) breakdown....
AMP1-1 alleviates bone loss in weightless rats by reducing peripheral 5-HT content via the microbiota-gut-bone axis [0.03%]
AMP1-1通过微生物群-肠-骨轴减少外周5-HT含量以缓解失重大鼠的骨丢失作用
Fan Yang,Qiuxin Yan,Yunhao Wang et al.
Fan Yang et al.
Background: Weightlessness-induced bone loss (WIBL) refers to the reduction of bone mass and the decline of bone resistance to load in a weightless environment. However, current treatment strategies aimed at increasing bo...
Multiomics combined analysis reveals protective effect of 7-O-α-L-rhamnopyranosyl-kaempferol-3-O-β-D-glucopyranoside on autoimmune hepatitis [0.03%]
多组学联合分析揭示7-O-α-L-鼠李糖吡喃葡萄糖醛酸基- kaempferol-3-O-β-D- glucopyranoside对自身免疫性肝炎的保护作用
Wei Xiao,Zhiqiang Li,Yilei Wang et al.
Wei Xiao et al.
Background: Autoimmune hepatitis (AIH) seriously endangers human health. Therefore, it is urgent to find new therapeutic drugs and targets for AIH. In this context, 7-O-α-L-rhamnopyranosyl-kaempferol-3-O-β-D-glucopyrano...
Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis [0.03%]
胡桃醌通过FOSL1-HMOX1轴诱导肝细胞癌和泛癌的铁死亡效应
Chuyu Wang,Ying Zhao,Yingfei Peng et al.
Chuyu Wang et al.
Background: Drug therapy plays an essential role in the management of hepatocellular carcinoma (HCC). Recently, the use of natural products to suppress tumor cells has emerged as a promising direction for drug development...
Exploring the anti-fatigue properties of ginseng stem and leaf saponins: Using UHPLC-MS metabolomics and neurotransmitter analysis [0.03%]
人参茎叶皂苷抗疲劳作用的代谢组学和神经递质分析研究
Meng Zhang,Rui Liu,Ting Zhou et al.
Meng Zhang et al.
Background: Chronic fatigue syndrome (CFS) is a crippling illness with limited effective treatment options. Recent findings have suggested that ginseng stem and leaf saponins (GSLS) possess anti-fatigue effects. However, ...
Inhibition of citrate transport reduces HIF-1α/GABA-T-mediated succinate accumulation in macrophages: The role of astragaloside IV in ischemic stroke [0.03%]
柠檬酸转运抑制减少HIF-1α/GABA-T介导的缺血性卒中巨噬细胞内琥珀酸累积： Astragaloside IV 的作用
Yi Li,Yu-Ning Zhang,Pei-Lin Zhang et al.
Yi Li et al.
Background: The occurrence of ischemic stroke is closely associated with the inflammatory infiltration of peripheral monocytes/macrophages, and the inflammatory activation of macrophages is often affected by metabolic rep...
Suoquan Wan mitigates bladder overactivity via modulation of neuroimmune homeostasis in perimenopausal rats [0.03%]
苏quate治疗围绝经期压力性尿失禁大鼠的神经免疫机制研究
Yao Zhang,Feng Zou,Lang Liang et al.
Yao Zhang et al.
Background: Overactive bladder (OAB) is a common disorder in perimenopausal women, involving detrusor regulation by bladder neuro-immune interactions. While Suoquan Wan (SQW) has shown efficacy in alleviating OAB symptoms...
The hidden potential of solasonine: Targeting non-small cell lung cancer (NSCLC) metastasis through GATM and Smad2 pathways [0.03%]
溶声碱的潜在作用：通过GATM和Smad2途径靶向非小细胞肺癌(NSCLC)转移
Cheng Hu,Jia-Qi Zhang,Xiao-Yu Zhuang et al.
Cheng Hu et al.
Purpose: To study the pharmacological effects of solasonine (Sol) in inhibiting non-small cell lung cancer (NSCLC) metastasis. Methods: ...
Hinokitiol ameliorates MASH in mice by therapeutic targeting of hepatic Nrf2 and inhibiting hepatocyte ferroptosis [0.03%]
hinokitiol通过治疗靶向肝脏Nrf2和抑制肝细胞铁死亡来改善小鼠MASH
Xunzhe Yin,Zuojia Liu,Chang Li et al.
Xunzhe Yin et al.
Background: Metabolic dysfunction-associated steatohepatitis (MASH), an advanced stage of metabolic dysfunction-associated steatotic liver disease (MASLD), still lacks approved effective clinical drugs. Ferroptosis, a for...
3-Hydroxypropionaldehyde modulates tryptophan metabolism to activate AhR signaling and alleviate ethanol-induced liver injury [0.03%]
3-羟基丙醛通过调节色氨酸代谢活化AhR信号通路以缓解酒精性肝损伤
Chen Liu,Yi Wang,Linlin Sheng et al.
Chen Liu et al.
Background: Although probiotics-based therapies and postbiotics derived from Lactobacillus reuteri (L. reuteri) hold promising potential in mitigating alcohol-associated liver disease (ALD), the role of L. reuteri's metab...