Yuqing Gu,Ze Li,Shu Zhou et al.
Yuqing Gu et al.
Background: Ginsenosides, the principal active ingredients in ginseng, have anti-bacterial, anti-inflammatory, antioxidant, anticancer, osteogenic, cardioprotective, and neuroprotective properties. Oral diseases afflict a...
Tetrandrine alleviates macrophage activation syndrome after CAR-T cell therapy [0.03%]
四氢小檗碱缓解CAR-T细胞治疗后的巨噬激活综合征
Youming Wang,Li Ding,Yingxiang Wang et al.
Youming Wang et al.
Background: Cytokine release syndrome (CRS) and secondary hemophagocytic lymphohistiocytosis (sHLH) are severe and potentially life-threatening complications after chimeric antigen receptor T (CAR-T) cell therapy, driven ...
Integrated transcriptomics and network pharmacology to reveal the mechanism of Physochlainae Radix in the treatment of asthma [0.03%]
整合转录组学和网络药理学揭示胎菊根治疗哮喘的机制
Jinyan Tan,Jianing Zhang,Weidong Yang et al.
Jinyan Tan et al.
Background: Physochlainae Radix (PR), a valuable traditional Chinese medicine, has been historically applied for the treatment of bronchitis and asthma in clinic, yet its mechanisms have not been clearly elucidated. ...
Glycyrol alleviates osteoporosis through dual modulation on osteoclastogenesis and osteogenesis by targeting Syk signaling pathway [0.03%]
甘草素通过靶向Syk信号通路调节破骨细胞生成和成骨细胞生成从而缓解骨质疏松症
Lihua Tan,Yanbei Tu,Zhimin Miao et al.
Lihua Tan et al.
Background: Osteoporosis, characterized by an imbalance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation, has become a serious public health challenge worldwide. Glycyrol (GC) is a repres...
Anemoside B4 targets NEK7 to inhibit NLRP3 inflammasome activation and alleviate MSU-induced acute gouty arthritis by modulating the NF-κB signaling pathway [0.03%]
龙葵素B4通过调节NF-κB信号通路靶向NEK7抑制NLRP3炎性小体活化从而缓解MSU诱导的急性痛风性关节炎
Xinghua Ni,Qinqin Wang,Yujie Ning et al.
Xinghua Ni et al.
Background: Acute gouty arthritis is a metabolic disorder caused by monosodium urate (MSU) accumulation, leading to NLRP3 inflammasome activation and joint inflammation. Anemoside B4 (B4), a pentacyclic triterpenoid sapon...
Erianin triggers ferroptosis in colorectal cancer cells by facilitating the ubiquitination and degradation of GPX4 [0.03%]
埃里那林通过促进GPX4泛素化降解诱导结直肠癌细胞铁死亡
Yuting Zheng,Yinli Zheng,Haipeng Chen et al.
Yuting Zheng et al.
Background: Colorectal cancer (CRC) continues to represent a significant global public health challenge. Ferroptosis, a novel form of cell death dependent on iron and involving lipid peroxidation, has emerged as an effect...
Dual role of Baimao-Longdan-Congrong-Fang in inhibiting Staphylococcus aureus virulence factors and regulating TNF-α/TNFR1/NF-κB/MMP9 axis [0.03%]
白茅.Longdn.苁蓉.防抑制金黄色葡萄球菌毒力因子及调控TNF-α/TNFR1/NF-κB/MMP9轴的双重作用
Tao Jiang,Xiujing Zhu,Zixin Yin et al.
Tao Jiang et al.
Background: Baimao-Longdan-Congrong-Fang (BLCF), a traditional Chinese herbal formula described in the Taiping Shenghui Fang (998 AD), consists of medicinal plants with heat-clearing and tonifying properties. BLCF has a p...
Innovative approaches in atherosclerosis treatment: Harnessing traditional Chinese medicine to target long non-coding RNAs [0.03%]
动脉粥样硬化治疗中利用传统中医药靶向长链非编码RNA的创新方法
Xiaofang Chen,Wenyan Ding,Yifan Liu et al.
Xiaofang Chen et al.
Background: Atherosclerosis (AS) is a major contributor to cardiovascular diseases, characterized by high morbidity and mortality rates. Long non-coding RNAs (LncRNAs), as members of non-protein coding RNAs, play a crucia...
Guizhi Shaoyao Zhimu Decoction alleviates rheumatoid arthritis by inhibiting inflammation by targeting SLPI [0.03%]
桂枝芍药知母汤通过靶向SLPI抑制炎症以缓解类风湿关节炎
Dongmei Pan,Yu Guo,Yi Liu et al.
Dongmei Pan et al.
Background: Guizhi Shaoyao Zhimu decoction (GSZD) is a recognised herbal formula that has demonstrated efficacy in the treatment of rheumatoid arthritis (RA). Despite its recognised clinical benefits and widespread use, t...
Fructosyl-mangiferin ameliorates dextran sulfate sodium-induced colitis in mice via the STAT3/M1/Th17 axis [0.03%]
果糖基芒果碱通过STAT3/M1/Th17轴改善葡聚糖硫酸钠诱导的小鼠结肠炎
Penghong Xu,Yuping Qian,Guo Xu et al.
Penghong Xu et al.
Background: Inflammatory bowel disease (IBD), a chronic inflammatory condition categorized into ulcerative colitis (UC) and Crohn's disease (CD), affects a growing global patient population. Despite the prevalence, clinic...