Huayu Tongbi formula attenuates rheumatoid arthritis by inhibiting the HIF1A/VEGFA/ANGPT axis and suppressing angiogenesis [0.03%]
华宇通痹方通过抑制HIF1A/VEGFA/ANGPT轴和抗血管生成来减轻类风湿性关节炎
Zifeng Chen,Xiang Guo,Simin Wu et al.
Zifeng Chen et al.
Background: Angiogenesis, integral to the pathogenesis of rheumatoid arthritis (RA), contributes to the advancement of synovial hyperplasia, pannus formation, and bone destruction. The precise effect of the Huayu Tongbi f...
Proteomic screening identifies brusatol targets TGFβRII to suppresses non-small cell lung cancer metastasis [0.03%]
蛋白质组筛选发现brusatol作用于TGFβRII以抑制非小细胞肺癌的转移
Guo-Sheng Lin,Rou-Qiao Zheng,Zi-Wei Xu et al.
Guo-Sheng Lin et al.
Background: Metastasis remains the leading cause of cancer mortality. The natural product brusatol (Bru) has exhibited promising anticancer activity; however, the target proteins of Bru and the underlying mechanisms in su...
Sclareol improves the pathology of Alzheimer's disease by inhibiting microglial inflammation via interacting with CDK9 [0.03%]
司卡雷醇通过与CDK9相互作用抑制小胶质细胞炎症从而改善阿尔茨海默病病理状态
Hao Tang,Luyao Li,Qin Yu et al.
Hao Tang et al.
Background: Excessive activation of microglia triggers pro-inflammatory responses, exacerbating neuronal damage and accelerating the progression of Alzheimer's disease (AD). Thus, targeting abnormal microglial activation ...
Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study [0.03%]
标准化酸橙果皮补充剂对睡眠紊乱成人有效性和安全性的研究：一项随机、双盲、安慰剂对照、多导睡眠图研究
Seonghui Kim,Min Young Um,Jin-Kyu Han et al.
Seonghui Kim et al.
Background: Citrus peels are rich in flavonoids with potential sedative-hypnotic effects; however, these effects have not yet been fully explored. We previously demonstrated that, in mice, standardized lime peel supplemen...
Gastrodin targets the system Xc-/GPX4 axis to inhibit abnormal proliferation of fibroblast-like synoviocytes and improve rheumatoid arthritis [0.03%]
gastrodin通过靶向系统Xc-/GPX4轴来抑制类风湿关节炎纤维母细胞样滑膜成纤维细胞的异常增殖从而改善类风湿关节炎
Yanlu Li,Aoyun Li,Yanchao Xing et al.
Yanlu Li et al.
Background: Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by the abnormal proliferation of Fibroblast-like Synoviocytes (FLS), leading to synovial hyperplasia and progressive joint destruction in...
Brusatol inhibits malignant phenotypes and lipid metabolism of osteosarcoma cells by regulating PI3K/AKT and MAPK pathways [0.03%]
Brusatol通过调节PI3K / AKT和MAPK途径抑制骨肉瘤细胞的恶性表型和脂质代谢
Xuhui Yuan,Shaolin Yu,Lan Lin et al.
Xuhui Yuan et al.
Background: Osteosarcoma (OS), the most frequent type of primary bone cancer, has a poor prognosis in metastatic cases, with overall 5-year survival rates stagnating at 20 %-30 %. This highlights the critical need for inn...
Rg3 inhibits hypoxia-induced tumor exosomes from boosting pancreatic cancer vasculogenic mimicry through the HIF-1α/LARS1/mTOR axis [0.03%]
Rg3通过HIF-1α/LARS1/mTOR轴抑制缺氧诱导的肿瘤外泌体促进胰腺癌血管生成模仿
Tingting Zhao,Xufan Cai,Hui Chen et al.
Tingting Zhao et al.
Background: Pancreatic cancer (PC), characterized by a poor prognosis, can utilize hypoxia to activate vasculogenic mimicry (VM) and facilitate metastasis. Exosomes serve as crucial mediators in this hypoxic environment. ...
Exploring the mechanism by which Zexie Tang regulates Alzheimer's disease: Insights from multi-omics analysis [0.03%]
泽泻汤调节阿尔茨海默病的机制探讨：多组学分析的见解
Shijie Su,Kongli Huang,Han Cai et al.
Shijie Su et al.
Background: Neurodegenerative disorders, such as Alzheimer's disease (AD), are characterized by a progressive decline in cognitive function. Modulating microglial metabolic reprogramming presents a promising therapeutic a...
Chaihuang Yishen Granule ameliorates mitochondrial homeostasis by upregulating PRDX5/TFAM axis to inhibit renal fibrosis in CKD [0.03%]
柴黄益肾颗粒通过上调PRDX5/TFAM轴改善线粒体稳态以抑制CKD的肾纤维化
Ling-Hui Xu,Rui-Zhi Tan,Jing-Yi Lin et al.
Ling-Hui Xu et al.
Background: Chaihuang Yishen Granules (CHYS) has been clinically proven to be effective for the treatment of chronic kidney disease (CKD), yet its underlying molecular mechanisms remain largely unexplored. ...
ErTao decoction alleviates liver fibrosis by suppressing STING-mediated macrophages and NLRP3 inflammasome activation [0.03%]
尔桃 decoction 通过抑制 STING 介导的巨噬细胞和 NLRP3 炎症小体活化来缓解肝纤维化
Hui Jia,Junjie Li,Xiaoting Chen et al.
Hui Jia et al.
Background: Liver fibrosis (LF) is a common pathological process in the progression of multiple chronic liver diseases to cirrhosis, affecting millions of people worldwide annually. The incomplete understanding of its mec...