(+)-Borneol enhances the protective effect of edaravone against cerebral ischemia/reperfusion injury by targeting OAT3/P-gp transporters for drug delivery into the brain [0.03%]
冰片通过靶向OAT3/P-gp转运体将药物传递到大脑从而增强依达拉奉对脑缺血/再灌注损伤的保护作用
Xin Wang,Jun-Jin Liu,Xin-Ru Zheng et al.
Xin Wang et al.
Objectives: Cerebral ischemia-reperfusion (CI/R) injury is a severe neurological condition associated with significant morbidity and mortality. Edaravone-dexborneol is a promising neuroprotective agent for alleviating CI/...
Isoforskolin, adenylate cyclase agonist, inhibits endothelial-to-mesenchymal transition in atherosclerosis [0.03%]
异 Forskolin，腺苷酸环化酶激动剂，在动脉粥样硬化中抑制内皮向间充质转化
Yiming Ma,Yunke Shi,Jinping Lun et al.
Yiming Ma et al.
Background: Atherosclerosis is a common chronic disease characterized by the formation of atheromatous plaques and endothelial dysfunction. Endothelial-to-mesenchymal transition (EndMT) has been identified as a crucial dr...
Berberine protects against dysentery by targeting both Shigella filamentous temperature sensitive protein Z and host pyroptosis: Resolving in vitro-vivo effect discrepancy [0.03%]
黄连素通过作用宿主细胞焦亡和致病菌丝状温度敏感蛋白Z发挥抗痢疾效应：体内外效果差异的解析
Xiangyin Chi,Jinwen Ding,Yu Zhang et al.
Xiangyin Chi et al.
Background: Berberine (BBR), an isoquinoline alkaloid, has been applied clinically to treat dysentery caused by Shigella for decades. Nevertheless, the precise mechanisms behind its anti-Shigella effect have not been full...
Celastrol-loaded ginsenoside Rg3 liposomes enhance anti-programmed death ligand 1 immunotherapy by inducing immunogenic cell death in triple-negative breast cancer [0.03%]
负载Celastrol的拟人参皂苷Rg3脂质体通过诱导三阴性乳腺癌的免疫原性细胞死亡增强抗程序性死亡配体1免疫治疗
Jingyi Huang,Jingbin Shi,Ninghui Ma et al.
Jingyi Huang et al.
Background: Triple-negative breast cancer (TNBC), characterized by high heterogeneity and invasiveness. Currently, inducing immunogenic cell death (ICD) of tumor cells through approaches such as radiotherapy and chemother...
Linggui Zhugan decoction ameliorating mitochondrial damage of doxorubicin-induced cardiotoxicity by modulating the AMPK-FOXO3a pathway targeting BTG2 [0.03%]
苓桂术甘汤通过调节AMPK-FOXO3a通道靶向BTG2改善阿霉素引起的心脏毒性所致的线粒体损伤
Liang Kong,Yang Liu,Jia-Hua Wang et al.
Liang Kong et al.
Background: Doxorubicin (DOX), a widely used anthracycline chemotherapy agent, is effective against various malignant tumors. However, its clinical application is significantly limited due to dose-dependent cardiotoxicity...
Allicin alleviates traumatic brain injury-induced neuroinflammation by enhancing PKC-δ-mediated mitophagy [0.03%]
大蒜素通过促进PKC-δ介导的线粒体自噬来缓解创伤性脑损伤引起的神经炎症
Yue Cheng,Wei Gu,Xuechao Wu et al.
Yue Cheng et al.
Background: Traumatic brain injury (TBI) leads to neuroinflammation, which is a key contributor to the negative prognosis in TBI patients. Recent evidence indicates that allicin can prevent neuronal injury after TBI. Howe...
Baicalin alleviates lipid metabolism disorders in diabetic kidney disease via targeting FKBP51 [0.03%]
黄芩素通过作用于FKBP51改善糖尿病肾病的脂代谢紊乱
Mi Li,Hong-Yan Zhu,Shu-Yan Zhao et al.
Mi Li et al.
Background: Diabetic kidney disease (DKD) represents the primary aetiological factor in end-stage renal disease, wherein lipid metabolism disorders contribute to the progression of DKD. Baicalin, a composition from Scutel...
Uncovering the potential mechanism and bioactive compounds of Salviae Miltiorrhizae Radix et Rhizoma in attenuating diabetic retinopathy [0.03%]
柴胡根茎减轻糖尿病性视网膜病变的潜在机制及其活性化合物研究
Shiyuan Dong,Yue Zhang,Yumin Xie et al.
Shiyuan Dong et al.
Background: Diabetic retinopathy (DR) is a serious microangiopathy resulting from diabetes. Salviae Miltiorrhizae Radix et Rhizoma (Danshen) is commonly used to treat cardiovascular diseases in clinics in China. However, ...
Tianqi Yizhi Granule alleviates cognitive dysfunction and neurodegeneration in SAMP8 mice via the PKC/ERK pathway [0.03%]
天芪一枝膏通过PKC/ERK通路改善SAMP8小鼠认知功能障碍及神经退行病变
Yi Zeng,Sixia Yang,Zeping Xie et al.
Yi Zeng et al.
Background: Given the lack of satisfactory clinical treatments for Alzheimer's disease (AD), a neurodegenerative condition detrimental to health, developing alternative therapies is critical. Tianqi Yizhi Granule (TQYZ) i...
Siegesbeckia orientalis ethanol extract impedes RAGE-CD11b interaction driven by HMGB1 to alleviate neutrophil-involved neuronal injury poststroke [0.03%]
东方香茶菜乙醇提取物通过阻碍HMGB1驱动的RAGE-CD11b相互作用来缓解中风后中性粒细胞相关的神经元损伤
Jinfen Chen,Xingping Quan,Yiyang Li et al.
Jinfen Chen et al.
Background: Ischemic stroke is a life-threatening cerebrovascular disease with limited therapeutic options. During the progression of acute ischemic stroke (AIS), neutrophil-involved inflammation mediated by high mobility...