Tubeimoside Ⅰ targets sodium/potassium ATPase alpha 1 subunit to selectively eliminate senescent cells and alleviate aging-associated abnormalities [0.03%]
管蛋白莫-side I通过靶向钠钾ATP酶α1亚基选择性清除衰老细胞并缓解与衰老相关异常现象
Hao Jiang,Yuanyuan Xue,Zelong Miao et al.
Hao Jiang et al.
Background: Senescent cells accumulate with age and contribute to age-related diseases, which makes their selective elimination a promising strategy for therapeutic intervention. Tubeimoside I (TBMS1), a natural triterpen...
Targeted nanoemulsion Blocks MTFR2-HIF-1α-EZH2/FoxM1 axis to suppress tongue squamous cell carcinoma invasion and metastasis [0.03%]
靶向纳微乳液通过抑制MTFR2-HIF-1α-EZH2/FoxM1轴来阻遏舌鳞状细胞癌侵袭和转移
Juan Zhan,Jian Han Zhou,Run Qiang Liu et al.
Juan Zhan et al.
Objective: Tongue squamous cell carcinoma (TSCC) is characterized by high invasiveness and early lymph node metastasis, leading to a poor prognosis.Current surgical and chemoradiotherapy regimens often cause functional im...
Kaempferol alleviates schizophrenia-like social and cognitive deficits through cholinergic modulation [0.03%]
山柰酚通过胆碱能调控缓解类似精神分裂症的社会和认知缺陷
Minzhu Li,Boshi Wang,Chenshu Gao et al.
Minzhu Li et al.
Background: Conventional antipsychotics exhibit limited efficacy in treating the negative symptoms and cognitive deficits of schizophrenia. Although the dietary flavonoid kaempferol has demonstrated neuroprotective effect...
Lithocarpus litseifolius and trilobatin ameliorate diabetic nephropathy through alleviating carbonyl stress by inhibiting AGEs/RAGE/NF-κB pathway [0.03%]
化石化棕榈素叶石栎和三氧苯并噻唑通过抑制AGEs / RAGE / NF- κB通路改善羰基应激治疗糖尿病肾病
Xue-Min Chen,Jie-Xin Chen,Xiao-Mei Chen et al.
Xue-Min Chen et al.
Background: Diabetic nephropathy (DN) is a major complication of diabetes, and reactive carbonyl species (RCS) that induce carbonyl stress are key mediators in its pathogenesis. Lithocarpus litseifolius (LI), also known a...
Da-Bu-Yin-Wan and Qian-Zheng-San regulate neuroinflammation and intestinal permeability through the microbiota-gut-brain axis in Parkinson's disease mice [0.03%]
大补阴丸和千震散通过微生态-肠-脑轴调节帕金森病小鼠神经炎症及肠道通透性
Huimin Zhu,Jing Feng,Hua Xu et al.
Huimin Zhu et al.
Background: Parkinson's disease (PD) is marked by progressive neurodegeneration and is becoming more widespread across the globe. Da-Bu-Yin-Wan and Qian-Zheng-San (BYQZF) is a compound from Chinese medicine known for its ...
Trilobatin alleviates polycystic ovary syndrome in rats by targeting SIRT2-Mediated PKM2 acetylation in glycolysis and mitochondrial function [0.03%]
三七总皂苷通过靶向SIRT2介导的PKM2乙酰化改善PCOS大鼠糖酵解和线粒体功能失调
Jing-Hang Li,Xian-Feng Yu,Shu-Ming Shi et al.
Jing-Hang Li et al.
Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that severely impacts female fertility. The natural dihydrochalcone trilobatin (TLB) has shown potential in managing metabolic diseases; howev...
Panax notoginseng saponins enhance osteogenesis-angiogenesis coupling to ameliorate osteoporosis combined with intervertebral disc degeneration [0.03%]
三七总皂苷通过促进成骨 angiogenesis偶联改善骨量流失及椎间盘退变
Fangli Huang,Hao Hu,Yan Chen et al.
Fangli Huang et al.
Background: Osteoporosis (OP) combined with Intervertebral disc degeneration (IDD) is a chronic degenerative disease. There are no drugs that simultaneously treat both IDD and OP. Panax notoginseng saponins (PNS) can trea...
Astragaloside IV delays vascular aging by enhancing mitochondrial fatty acid β-oxidation via the MLXIPL-PPARα/PGC-1α axis [0.03%]
Astragaloside IV通过MLXIPL-PPARα/PGC-1α轴增强线粒体脂肪酸β氧化来延缓血管衰老
Xiangyu Chen,Xiaodie Chen,Nan Xiao et al.
Xiangyu Chen et al.
Background: Mitochondrial dysfunction and the dysregulation of lipid metabolism are significant contributors to vascular aging, which in turn raises the risk of age-related cardiovascular diseases (CVDs). Buyang Huanwu de...
Daphnoretin targeted binding to HSP90AA1 to promote P53 UFMylation and stability thereby inducing apoptosis in colorectal cancer [0.03%]
丁香愈创奥树脂酚通过靶向HSP90AA1促进P53泛素化并提高其稳定性从而诱导结直肠癌细胞凋亡
Lianghe Li,Lei Li,Wei Zhan et al.
Lianghe Li et al.
Background: Daphnoretin (DAP), the principal bioactive constituent isolated from the traditional Chinese medicinal herb Wikstroemia indica rasix (WIR), exhibits well-documented pharmacological properties-including anti-in...
Dangshen formula Shengmai-Yin suppresses atherosclerosis through restoring the gut microbiota and homeostatic efferocytosis [0.03%]
党参生脉饮通过恢复肠道微生物群和稳态摄取作用来抑制动脉粥样硬化
Yang Li,Feixia Wang,Mengru Hu et al.
Yang Li et al.
Background & aims: Atherosclerosis (AS) is a chronic progressive vascular disease characterized by lipid deposition and aortic inflammation. On the basis of traditional Chinese medicine (TCM) theory, the Dangshen Formula ...