Benzoylpaeoniflorin alleviates ulcerative colitis by inhibiting ferroptosis through targeting phosphogluconic dehydrogenase [0.03%]
苯酰芍药苷通过靶向磷酸葡萄糖脱氢酶抑制铁死亡从而缓解溃疡性结肠炎
Yang Tang,Zheng Wang,Feng Zhou et al.
Yang Tang et al.
Background: Ulcerative colitis (UC) is a clinically refractory diseases of the digestive system. Benzoylpaeoniflorin (BP) is a compound from Baishao, a Chinese herbal medicine documented with effects of anti-enteritis. Ho...
Coix seed oil alleviates collagen-induced arthritis-associated muscle atrophy and functional decline by modulating gut microbiota dysbiosis [0.03%]
薏米油通过调节肠道菌群失调缓解 коллаген-诱导的关节炎相关的肌肉萎缩和功能下降
Yuyang Bai,Xiaoyu Zhang,Fanxin Ouyang et al.
Yuyang Bai et al.
Backgroud: The gut microbiota composition influences the pathogenesis of sarcopenia via the "gut microbiota-muscle axis", with probiotics serving as potential therapeutic agents. Coix seed oil (CSO), a bioactive component...
Yindan Xinnaotong Soft Capsule improves post-ischemic stroke recovery by regulating CREB/BDNF-mediated synaptic plasticity and CREB/VEGFA-mediated angiogenesis [0.03%]
银丹心脑通软胶囊通过调节CREB/Bdnf介导的突触可塑性和CREB/Vegfa介导的血管生成促进缺血性中风后恢复
Cuicui Cheng,Huijuan Liu,Guoqiang Guan et al.
Cuicui Cheng et al.
Background: Ischemic stroke is a leading cause of disability and cognitive impairment. Yindan Xinnaotong Soft Capsule (YD), a traditional Chinese patent medicine, is clinically utilized for cardio-cerebrovascular diseases...
Nobiletin promotes ferroptosis in breast cancer through targeting AKR1C1-mediated ubiquitination and degradation of GPX4 [0.03%]
楠皮素通过靶向AKR1C1介导的GPX4泛素化降解在乳腺癌中促进铁死亡的作用机制研究
Yuan Wu,Yuxi Li,Yuqing Huang et al.
Yuan Wu et al.
Background: Nobiletin, a major component derived from the natural product Citrus reticulata Blanco, has been shown to exhibit potent anti-cancer activity across various cancer types. However, the mechanisms underlying its...
20S-O-Glc-DM regulates fatty acid metabolism and mitochondrial function in the treatment of diabetes mellitus-associated MAFLD [0.03%]
20S-O-葡萄糖二氢山柰酚调节脂肪酸代谢和线粒体功能以治疗糖尿病相关MAFLD
Chen Gao,Lingzhi Zhang,Xinyi Guo et al.
Chen Gao et al.
Background: The prevalence of diabetes mellitus-associated metabolic dysfunction-associated fatty liver disease (MAFLD) is on the rise, with over 90% of patients with Type 2 Diabetes Mellitus (T2DM) also suffering from MA...
Wuwei Ganlu and Myricetin alleviate rheumatoid arthritis by inhibiting M1 macrophage polarization through modulation of SHBG/SREBP1-mediated lipid metabolism [0.03%]
甘露回春口服液通过调节SHBG/SREBP1介导的脂质代谢抑制M1型巨噬细胞极化从而缓解类风湿性关节炎
Yuanyuan Wen,Yutong Wang,Youyi Zhuang et al.
Yuanyuan Wen et al.
Background: Rheumatoid arthritis (RA) is primarily characterized by imbalanced macrophage polarization. Wuwei Ganlu (WGL), a classical Tibetan topical formula, has been widely used in RA management. ...
Ramulus Mori (Sangzhi) alkaloids enhance pancreatic β-Cell maturation and function by targeting the CD81/endoplasmic reticulum stress pathway [0.03%]
桑枝生物碱通过靶向CD81/内质网应力通路促进胰岛β细胞的成熟和功能
Nan Wu,Wenjing Zhang,Sunyue He et al.
Nan Wu et al.
Background: β-cell dedifferentiation and impaired maturation are crucial contributors to β-cell dysfunction in type 2 diabetes mellitus (T2DM), yet targeted therapies remain limited. ...
Rottlerin inhibits PKCδ to attenuate pulmonary fibrosis by suppressing NLRC4/ASC-mediated pyroptosis [0.03%]
罗塔灵通过抑制PKCδ来减弱NLRP3介导的肺纤维化细胞焦亡作用
Yuanyi Wang,Ting Zhang,Xijun Gou et al.
Yuanyi Wang et al.
Background: Pulmonary fibrosis (PF) is a progressive and fatal lung disease with limited treatment options. Targeting the underlying inflammatory and cell death mechanisms holds promise for developing novel therapies. Rot...
Reynoutrin activates Sirt1/Foxo3a and Nrf2 pathway via targeting Fyn to ameliorate diabetic nephropathy [0.03%]
瑞纽亭通过靶向Fyn激活Sirt1/Foxo3a和Nrf2途径改善糖尿病肾病
Shanshan Li,Haiming Xiao,Xuting Zhang et al.
Shanshan Li et al.
Background: Diabetic nephropathy (DN) is a major complication of diabetes, associated with high mortality and disability rates. Fyn kinase has emerged as a promising therapeutic target for DN due to its antioxidant proper...
Wogonin modulates macrophage polarization and inflammatory signaling through the LSD1-p65 axis to alleviate osteoarthritis [0.03%]
沃格农素通过LSD1-p65轴调节巨噬细胞极化和炎症信号以缓解骨关节炎
Zhe Cai,Chengyu Lu,Dehui Chen et al.
Zhe Cai et al.
Background: The study elucidates wogonin's therapeutic mechanisms in osteoarthritis (OA) induced by medial meniscus destabilization (DMM), focusing on macrophage polarization regulation, inflammatory signaling modulation,...