EGCG inhibits tobacco smoke-promoted proliferation of lung cancer cells through targeting CCL5 [0.03%]
EGCG通过作用于CCL5抑制烟草促肺癌细胞的增殖
Zhiyuan Dong,Jinyi Wu,Liping He et al.
Zhiyuan Dong et al.
Background: The occurrence and development of cancer are deeply intertwined with chronic inflammatory processes. Epigallocatechin gallate (EGCG), the most pharmacologically potent catechin derived from tea, has garnered a...
Ligustilide covalently binds to Cys254 of the creatine kinase, M-type protein, ameliorating acute myocardial ischemia by enhancing the creatine phosphate level [0.03%]
茴香婆罗双亭通过与肌酸激酶M型蛋白的Cys254共价结合，通过提高磷酸肌酸水平来改善急性心肌缺血
Kaixue Zhang,Guoqing Luan,Jin Zhang et al.
Kaixue Zhang et al.
Background: Myocardial ischemia (MI) threatens the health of middle-aged and older adults by reducing cardiac oxygen supply and function. Current therapies, including vasodilation, thrombolysis, and interventions, focus o...
Sakuranetin ameliorates experimental colitis in a gut microbiota-dependent manner [0.03%]
樱黄素以依赖肠道微生物群的方式改善实验性结肠炎
Lian Wang,Zhen Zhang,Xiaohua Chen et al.
Lian Wang et al.
Background: The progression of inflammatory bowel disease (IBD) is closely connected with intestinal flora dysbiosis. Sakuranetin (SAK) is a natural compound with anti-inflammatory and antibiosis activities. We investigat...
Lycium barbarum extract improves brain and visual functions in mice models of Alzheimer's disease through activating WNT pathway [0.03%]
枸杞提取物通过激活Wnt通路提高阿尔茨海默氏症小鼠模型的脑和视觉功能
Xiu Han,Mengrong Zhang,Yajing Liu et al.
Xiu Han et al.
Background: Alzheimer's disease (AD) is the leading cause of dementia in the elderly, characterized by visual deficits and cognitive impairment. However, current therapies have limited efficacy. ...
Integrating serum pharmacochemistry, network pharmacology, metabolomics and 16S rRNA sequencing to explore the mechanism of total flavonoids from Flemingia philippinensis in treating collagen induced arthritis rats [0.03%]
整合血清药化学，网络药理学，代谢组学和16S rRNA测序来探索菲律宾 Flemingia总黄酮治疗胶原诱导的关节炎大鼠的机制
Jingwen Qiu,Yingyin Zhang,Kairan Chen et al.
Jingwen Qiu et al.
Backgroud: Rheumatoid arthritis (RA) is a prevalent chronic autoimmune disease characterized by symmetric polyarthritis, resulting in pain and swelling in the synovial joints. Flemingia philippinensis, a traditional Chine...
Targeting ferroptosis in the treatment of ulcerative colitis by traditional Chinese medicine: A novel therapeutic strategies [0.03%]
中医药通过促进铁死亡治疗溃疡性结肠炎：一种新型的治疗策略
Ying Liu,Jing-Tian Zhang,Meng Sun et al.
Ying Liu et al.
Background: The incidence of ulcerative colitis (UC) has been rising rapidly in recent years, and there is currently no effective method to prevent its recurrence. Owing to its long treatment duration, difficulty in treat...
An effective strategy for exploring the taste markers in alum-processed Pinellia ternata tuber based on the analysis of substance and taste by LC-MS and electronic tongue [0.03%]
基于LC-MS和电子舌的性味物质分析探讨明矾炮制半夏辛味标志物的有效策略
Jun-Li Kang,Jia-Wei Wang,Xiang-Dong Chen et al.
Jun-Li Kang et al.
Objective: To explore the taste-related quality markers of Qingbanxia, the alum-processed Pinellia ternata tuber. Methods: Eighteen sam...
Shenfuyixin Granules enhance mitochondrial autophagy after myocardial infarction by regulating protein deacetylation via the SIRT3/FOXO1 signaling axis [0.03%]
沈福亦信颗粒通过调节SIRT3/FOXO1信号轴的蛋白去乙酰化促进心肌梗死后线粒体自噬
Lanxin Li,Shanshan Nie,Bin Wang et al.
Lanxin Li et al.
Background: Heart failure (HF) represents the terminal stage of various cardiovascular diseases, with current treatment options remaining limited. Shenfuyixin Granules (SFYX) have been integrated into clinical practice, d...
A topical Chinese herbal inhibits pruritus and skin inflammation via neural TRPM8 in atopic dermatitis [0.03%]
一种外用的中药通过激活神经上的TRPM8受体抑制特应性皮炎中的瘙痒和皮肤炎症
Yao Chen,Ziyuan Tang,Zhiyao Han et al.
Yao Chen et al.
Background: Atopic dermatitis (AD) is a chronic, itchy, and inflammatory skin disease. The neuroimmune concept of itch involves aberrant immune responses and neural activities. Chinese herbal medicine has been demonstrate...
Dihydromyricetin regulates the miR-155-5p/SIRT1/VDAC1 pathway to promote liver regeneration and improve alcohol-induced liver injury [0.03%]
二氢杨梅素通过调节miR-155-5p/SIRT1/VDAC1通路促进肝脏再生并改善酒精性肝损伤
Qing Ma,Shuo Huang,Mei-Ya Li et al.
Qing Ma et al.
Background: Alcohol-related liver disease (ALD) has become an increasingly serious global health issue. In recent years, growing evidence has highlighted the restoration of liver regenerative capacity as an effective ther...