Quercetin attenuated necroptosis and apoptosis caused by LPS-induced mitochondrial function dysfunction through the METTL3-mediated PTEN m6A methylation/PI3K/AKT signaling in broiler livers [0.03%]
黄酮通过METTL3介导的PTEN m6A甲基化/PI3K/AKT信号通路减轻LPS诱导的鸡肝线粒体功能障碍所致的坏死和凋亡
Yu Xia,Yidan Wang,Kai Chen et al.
Yu Xia et al.
Background: Quercetin (QUE), a natural flavonoid, offered an efficient protection against organism injury. N6-methyladenosine (m6A) methylation is considered to be the most prevalent and abundant modifications involved in...
Notoginsenoside R1 reduces acquired lymphedema and increases lymphangiogenesis by promoting VEGF-C expression via cAMP/PKA/CREB signaling [0.03%]
人参皂苷R1通过促进cAMP/PKA/CREB信号的VEGF-C表达减少继发性淋巴水肿并增加淋巴管生成
Jia-Min Bao,Tong Hou,Li Zhao et al.
Jia-Min Bao et al.
Background: Acquired lymphedema is a global health concern with limited treatment options. While vascular endothelial growth factor C (VEGF-C) administration has shown promise for the treatment of this patient population,...
Clematichinenoside AR alleviates rheumatoid arthritis by inhibiting synovial angiogenesis through the HIF-1α/VEGFA/ANG2 axis [0.03%]
Clematichinenoside AR通过HIF-1α/VEGFA/ANG2轴抑制滑膜血管生成从而缓解类风湿关节炎
Meiling Yuan,Yajie Wu,Xinyue Zhou et al.
Meiling Yuan et al.
Background: Clematichinenoside AR (CAR) is an effective monomer component of Clematis chinensis Osbeck, which has therapeutic effects on rheumatoid arthritis (RA), but its specific mechanism is still not fully elucidated....
Efficacy and safety of Shexiang Baoxin Pill in patients with angina and non-obstructive coronary arteries: A multicenter, randomized, double-blind, placebo-controlled, phase Ⅳ clinical trial [0.03%]
养心保冠丸对心绞痛和非阻塞性冠状动脉患者的有效性和安全性：多中心、随机、双盲、安慰剂对照、第四阶段临床试验
Zhiqing He,Na Li,Wei Zhang et al.
Zhiqing He et al.
Introduction: Solid evidence generated from large studies supporting the recommendation of Shexiang Baoxin Pill (MUSKARDIA) as a promising treatment for angina and nonobstructive coronary arteries (ANOCA) populations is l...
5-hydroxymethylfurfural attenuates osteoarthritis by upregulating of glucose metabolism in chondrocytes [0.03%]
5-羟甲基糠醛通过上调软骨细胞糖代谢来减轻骨关节炎
Xinyu Wang,Xiaolong Han,Jinjin Ma et al.
Xinyu Wang et al.
Introduction: 5-HMF (5-hydroxymethylfurfural), an active constituent found in Radix Rehmanniae Preparata, a widely utilized traditional Chinese medicine for osteoarthritis (OA) treatment, exhibits notable therapeutic bene...
Qingyi decoction and its active ingredients ameliorate acute pancreatitis by regulating acinar cells and macrophages via NF-κB/NLRP3/Caspase-1 pathways [0.03%]
清胰汤及其活性成分通过NF-κB/NLRP3/Caspase-1途径调节胰腺腺泡细胞和巨噬细胞从而减轻急性胰腺炎
Yu An,Zhengwei Tu,Ao Wang et al.
Yu An et al.
Background and purpose: Macrophage infiltration and activation is a critical step during acute pancreatitis (AP). NLRP3 inflammasomes in macrophages plays a critical role in mediating pancreatic inflammatory responses. Qi...
Pianchou Gongpan,Tingting Xu,Yufei Zhang et al.
Pianchou Gongpan et al.
Background: Uncontrolled inflammation is a key factor in the development of many diseases, and targeting pivotal kinases involved in the inflammatory response, such as interleukin-1 receptor-associated kinase 4 (IRAK4), h...
Panax notoginseng saponins ameliorate LPS-induced acute lung injury by promoting STAT6-mediated M2-like macrophage polarization [0.03%]
三七皂苷通过促进STAT6介导的M2样巨噬细胞极化改善LPS诱导的急性肺损伤
Xunjiang Wang,Hanyang Zhao,Wenyuan Lin et al.
Xunjiang Wang et al.
Background: Acute lung injury (ALI) is a severe inflammatory condition characterized by dysregulated immune responses and high mortality rates, with limited effective therapeutic options currently available. Panax notogin...
Jinkui Shenqi decoction targets PAD4 to restrain NETosis and ameliorates psoriasis progression [0.03%]
金匮肾气汤通过作用于PAD4蛋白抑制NETs的释放从而改善银屑病进程
Wanjun Zhao,Xiaoyan Liu,Jianing Tang et al.
Wanjun Zhao et al.
Background: The underlying pathogenesis of psoriasis was attributed to insufficient kidney qi and blood stasis arising from impeded blood circulation. Jinkui Shenqi decoction (JKSQD), was renowned for its capacity to warm...
Advances in bioinformatic methods for the acceleration of the drug discovery from nature [0.03%]
加速从自然界发现药物的生物信息学方法的进展
Magdalena Maciejewska-Turska,Milen I Georgiev,Guoyin Kai et al.
Magdalena Maciejewska-Turska et al.
Background: Drug discovery from nature has a long, ethnopharmacologically-based background. Today, natural resources are undeniably vital reservoirs of active molecules or drug leads. Advances in (bio)informatics and comp...