Procyanidins inhibit alphacoronavirus infection by reducing interferon antagonism [0.03%]
原花青素通过减少干扰素拮抗来抑制alphacoronavirus感染
Yi Liu,Xue Wang,Xuefei Wang et al.
Yi Liu et al.
Background: The development of coronavirus drugs has primarily focused on targeting viral components, such as RNA-dependent RNA polymerase (RdRP), with relatively little attention given to enhancing host antiviral defense...
Astragali Radix-Curcumae Rhizoma normalizes tumor blood vessels by HIF-1α to anti-tumor metastasis in colon cancer [0.03%]
黄芪与莪术通过HIF-1α normalization对结肠癌肿瘤血管的正常化以抗肿瘤转移
Yan Liang,Tingting Su,Shijiao Zhu et al.
Yan Liang et al.
Background: Abnormal tumor blood vessels can significantly promote the malignant progression of tumors, prompting researchers to focus on drugs that normalize these vessels for clinical treatment. The combination of the Q...
Study on the mechanism of Trichosanthes kirilowii Maxim. against COPD based on serum chemical composition analysis, network pharmacology, and experimental study [0.03%]
基于血清化学成分分析、网络药理学及实验研究的伊木兰抗慢阻肺机制研究
PengLiang Shi,BingQing Zheng,Yan Cao et al.
PengLiang Shi et al.
Background: Trichiosanthis Pericarpium (TP) is the dried ripe peel of Trichosanthes kirilowii Maxim., also known as gualoupi in Chinese, effectively clears heat and transforms phlegm. Traditional Chinese medicine (TCM) pr...
Polyphenol extract ameliorates diabetes-related atherosclerosis through HIF-1 signaling pathway in APOE-/- mice: Possible synergism with atorvastatin [0.03%]
黄酮提取物通过HIF-1信号通路改善APOE-/-小鼠糖尿病相关的动脉粥样硬化：与阿托伐他汀的协同作用可能性
Yang Yang,Shengxiang Chen,Guanjin Shi et al.
Yang Yang et al.
Background: Diabetes mellitus promotes atherosclerosis (AS), a major cause of cardiovascular disease. Statins, clinical drugs for AS treatment, may increase the risk of diabetes and induce hepatotoxicity. Polyphenols can ...
Triterpenoids from ilicis rotundae cortex ameliorate hyperlipidemia by affecting bile acids-hepatointestinal FXR axis [0.03%]
悬铃科柯属植物皮中的三萜通过影响胆酸-肝肠道FXR轴改善高脂血症
Wei Zeng,Mengjia Sun,Jiamin Cao et al.
Wei Zeng et al.
Background: Hyperlipidemia is a lipid metabolism disorder that, in severe cases, can lead to conditions such as hypertension, coronary heart disease, and cirrhosis. Previous studies have identified Ilicis Rotundae Cortex ...
Exploring the therapeutic potential of HAPC in COVID-19-induced acute lung injury [0.03%]
探索HAPC在COVID-19诱导的急性肺损伤中的治疗潜力
Zhichen Pu,Lingling Li,Yan Zhang et al.
Zhichen Pu et al.
Background: Acute lung injury (ALI) is one of the critical complications of coronavirus disease 2019 (COVID-19), which significantly impacts the survival of patients. ...
Novel anti-inflammatory compounds that alleviate experimental autoimmune encephalomyelitis [0.03%]
具有缓解实验性自身免疫性脑脊髓炎作用的新型抗炎化合物
Mengjiao Sun,Ning Liu,Jing Sun et al.
Mengjiao Sun et al.
Background: Multiple sclerosis (MS) is an autoimmune disease primarily characterized by inflammatory demyelination. Despite significant research efforts, effective therapies for MS remain limited. Drug screening offers a ...
Pectin-coated Malvidin-3-O-galactoside attenuates silica-induced pulmonary fibrosis by promoting mitochondrial autophagy and inhibiting cell apoptosis [0.03%]
果胶包覆的花青素-3-O-半乳糖苷通过促进线粒体自噬和抑制细胞凋亡减轻二氧化硅诱导的肺纤维化
Yihan Yang,Chuang Ma,Yining Wang et al.
Yihan Yang et al.
Background: Blueberries are a rich source of anthocyanins, which have been established to have multiple beneficial properties. However, the structure of anthocyanin monomers is unstable and their bioavailability is low. T...
Hua Zheng San Ji Fang suppresses liver cancer progression by inhibiting TYRO3 expression via the ERK signaling pathway [0.03%]
通过ERK信号通路抑制TYRO3表达,Hua Zheng San Ji Fang抑制肝癌进展
Zhuang Xiong,Xiaodan Sui,Yu Bai et al.
Zhuang Xiong et al.
Background: Liver cancer poses a significant global health challenge owing to its increasing incidence and associated mortality rates. Traditional Chinese Medicine (TCM) has garnered attention for its potential in oncolog...
L-theanine ameliorates traumatic-brain-injury-induced hippocampal neuronal death in rats [0.03%]
L-茶氨酸改善大鼠创伤性脑损伤引起的海马神经元死亡
Min Kyu Park,Bo Young Choi,A Ra Kho et al.
Min Kyu Park et al.
Background: Traumatic brain injury (TBI) is a major health concern, often resulting in significant brain damage and functional impairments. A key contributing factor to TBI-induced neuronal injury is the overactivation of...