Resveratrol in animal models of pancreatitis and pancreatic cancer: A systematic review with machine learning [0.03%]
动物模型中白藜芦醇对胰腺炎和胰腺癌的影响：基于机器学习的系统性回顾
Wenhao Cai,Ziyu Li,Wen Wang et al.
Wenhao Cai et al.
Background: Resveratrol (RES), a common type of plant polyphenols, has demonstrated promising therapeutic efficacy and safety in animal models of pancreatitis and pancreatic cancer. However, a comprehensive analysis of th...
Polysaccharide from Pyrus pashia Buch ameliorates DSS-induced colitis in mice via MAPKP38/NF-κB P65 and SCFAs/ERK/MSK signaling pathways [0.03%]
Pyrus pashia Buch中提取的多糖通过MAPKP38/NF-κB P65和SCFAs/ERK/MSK信号通路改善小鼠DSS诱导的结肠炎
Yan Zhang,Jiaxin Han,Jiaqi Gao et al.
Yan Zhang et al.
Purpose: In this experiment, we investigated the effect of Pyrus pashia Buch on the relevant inflammatory disease indexes, intestinal microbiota, and short-chain fatty acids in mice with dextran sodium sulfate (DSS)-induc...
Xin-Fu-Kang oral liquid mitigates chronic heart failure through NR4A1-Dependent regulation of endoplasmic reticulum-mitochondrial crosstalk in Cardiomyocytes [0.03%]
Xin Fu Kang口服液通过心肌细胞内质网-线粒体串扰的NR4A1依赖性调节对慢性心力衰竭起到治疗作用
Xiaohan Zhang,Xing Chang,Ruoning Chai et al.
Xiaohan Zhang et al.
Background: Chronic heart failure (CHF) is the terminus of a variety of cardiovascular diseases. Xin-Fu-Kang oral liquid (XFK), a natural herbal compound, has been used in CHF treatment for decades. However, further inves...
Jieyu Guben decoction alleviates combined allergic rhinitis and asthma syndrome by balancing Th17/Treg expression and restoring PPARD [0.03%]
洁隅固本饮通过平衡Th17/Treg的表达和恢复PPARD来缓解过敏性鼻炎合并哮喘综合征的效果研究
Yi He,Yanxia Liang,Maorong Fan et al.
Yi He et al.
Background: This study was designed to assess the efficacy of the Jieyu Guben Decoction (JYGBD), a novel formula that has not been reported, in treating rats with combined allergic rhinitis and asthma syndrome (CARAS) and...
Total glucosides of paeony alleviates Sjogren's syndrome by inhibiting Th1 and Th17 responses [0.03%]
芍药总苷通过抑制Th1和Th17免疫反应缓解干燥综合征
Ge Liu,Jiang Wang,Jing Liu et al.
Ge Liu et al.
Background: Sjogren's syndrome (SS) is distinguished by immune cells infiltration of exocrine glands, with T helper (Th) cells playing a crucial role in its progression. Total glucosides of paeony (TGP), the main compound...
Microbiota regulated by Shenling Baizhu powder maintains intestinal homeostasis via the gut-breast axis [0.03%]
参苓白术散调节的微生物群通过肠-乳腺轴维持肠道稳态
Weijie Lv,Tianze Wang,Shiqi He et al.
Weijie Lv et al.
Background: The response of the microbiota to weaning plays a crucial role in shaping long-term immunity and overall lifelong health. The gut and milk microbiota of mothers exert a profound influence on the microbiota and...
Baicalein inhibits hepatitis B virus through the coiled coil domain containing protein 88A (CCDC88A)-dependent autophagy pathway [0.03%]
黄芩素通过卷曲螺旋结构域含蛋白88A(CCDC88A)自噬途径抑制乙型肝炎病毒
Yi-Jun Niu,Xin Ai,Xiao-Tong Lin et al.
Yi-Jun Niu et al.
Background: Chronic infection with the hepatitis B virus (HBV) represents a significant global health concern. Baicalein, a naturally occurring flavone derived from the roots of Scutellaria baicalensis Georgi, has exhibit...
13-Methylpalmatine alleviates bleomycin-induced pulmonary fibrosis by suppressing the ITGA5/TGF-β/Smad signaling pathway [0.03%]
13-甲基掌叶防己碱通过抑制ITGA5/TGF-β/Smad信号通路缓解硫酸博来霉素诱导的肺纤维化
Qin Mao,Jiajing Liu,Yu Yan et al.
Qin Mao et al.
Background: Idiopathic pulmonary fibrosis (IPF) is an irreversible lung disease for which there is a lack of effective and safe therapeutic drugs. 13-Methylpalmatine (13-Me-PLT) is an active compound from Coptis chinensis...
Uncovering the underlying mechanism of yuanhuacine against colorectal cancer by transcriptomics and experimental investigations [0.03%]
元胡碱通过转录组学和实验研究对抗结直肠癌的潜在机制解析
Jingchu Li,Shanshan Liu,Jian Chen et al.
Jingchu Li et al.
Background: Colorectal cancer (CRC) holds the third position in terms of incidence and ranks behind lung cancer in terms of mortality worldwide. Yuanhuacine, one of the main active ingredients of genkwa flos, has demonstr...
Tianma Gouteng Decoction improve neuronal synaptic plasticity and oligodendrocyte apoptosis in Parkinson's disease mice [0.03%]
天麻钩藤饮通过改善神经元突触可塑性和少突胶质细胞凋亡对帕金森小鼠起到治疗作用
Tong Lei,Gaoshuang Fu,Xin Xue et al.
Tong Lei et al.
Background: Parkinson's disease (PD) is a complex and multifactorial disorder of the nervous system. Tianma Gouteng Decoction (TGD) is a clinical prescription of traditional Chinese medicine for PD, but its neuroprotectiv...