Unveiling the role of mast cells in breast cancer-a case study of natural product Eriocalyxin B as an inhibitor [0.03%]
揭开肥大细胞在乳腺癌中的作用-Eriocalyxin B作为抑制剂的一个案例研究
Leilei Gou,Grace Gar-Lee Yue,Ben Chung-Lap Chan et al.
Leilei Gou et al.
Background: Inflammation and breast cancer are closely associated. Considering that mast cells are essential component of inflammatory cells, its relationship with breast cancer arose rising attention. ...
Integrating untargeted/targeted metabolomics and network pharmacology association analysis to study the mechanism of safflower regulating C18:0 sphingolipid metabolism to treat acute myocardial ischemia [0.03%]
通过整合未靶向/靶向代谢组学和网络药理学关联分析研究红花通过调控C18：0神经节苷脂代谢治疗急性心肌缺血的机制
Zhixin Jia,Cong Fang,Mingxia Pan et al.
Zhixin Jia et al.
Background: Safflower extract (SE) has been reported to treat acute myocardial ischemia (AMI); however, its underlying mechanism remains unclear. Purpose:...
Deoxyshikonin from Arnebiae Radix promotes hair growth by targeting the Wnt/β-catenin signaling pathway [0.03%]
紫草索通过作用于Wnt/β-连环蛋白信号通路促进毛发生长
Yingna Li,Yanhong Mu,Xinyue Chen et al.
Yingna Li et al.
Background: Alopecia is a common skin condition with limited effective treatments. Arnebiae Radix (AR) is a traditional Asian herb used for various skin disorders. However, its specific components and the mechanisms under...
Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade [0.03%]
土虫素诱导的肝损伤通过不可修复的DNA损伤和自噬流阻塞
Yifan Lin,Jian Zhang,Xinyue Gao et al.
Yifan Lin et al.
Objective: The fruit of Melia toosendan Sieb. et Zucc. (MT) is known for its efficacy in relieving pain and treating roundworms. Toosendanin (TO) has been identified as a bioactive marker of MT, with hepatotoxic propertie...
Alkannin triggered apoptosis and ferroptosis in gastric cancer by suppressing lipid metabolism mediated by the c-Fos/SREBF1 axis [0.03%]
烷尼宁通过抑制c-Fos/SREBF1轴介导的脂质代谢触发胃癌中的细胞凋亡和铁死亡
Huayang Yu,Qiming Kou,Hang Yuan et al.
Huayang Yu et al.
Background: Gastric cancer (GC), one of the most common malignancies with high mortality worldwide, currently requires beneficial therapeutic strategies. Alkannin is the primary active component of Lithospermum erythrorhi...
Jingwen Niu,Guoqi Zhu,Junjie Zhang
Jingwen Niu
Background: The Shennong Bencao Jing (Shennong's Classic of Materia Medica) records that Panax ginseng C. A. Mey (ginseng) 'lightens the body and prolongs life'. Many investigations have documented that ginseng exerts neu...
Modulation of Pseudomonas aeruginosa-induced avoidance behavior by Shen Qi pills via mitogen-activated protein kinase PMK-1 and forkhead box protein O DAF-16 in Caenorhabditis elegans [0.03%]
六味地黄丸通过PMK-1和叉头盒蛋白O DAF-16调解对铜绿假单胞菌的回避行为研究
Hanxiao Wang,Siyi Lin,Yingying Xu et al.
Hanxiao Wang et al.
Background: Avoidance behavior is one of the core features of anxiety and related in-depth study can help to reveal the biological basis of these disorders. In recent years, traditional Chinese medicine has incorporated S...
SIRT3 suppresses vascular endothelial senescence via DHRS2 and contributes to the anti-vascular aging effect of Bazi Bushen capsule [0.03%]
SIRT3通过DHRS2抑制血管内皮细胞衰老并有助于八子补肾胶囊的抗血管衰老效应
Yuan Zhao,Chunmei Zhang,Chen Zhang et al.
Yuan Zhao et al.
Aims: Vascular and endothelial aging are significant causes of chronic diseases among the elderly. This study investigated the specific mechanism by which sirtuin 3 (SIRT3) regulates vascular endothelial senescence and th...
Smilax glabra roxb. alleviates cisplatin-induced acute kidney injury in mice by activating the Nrf2/HO-1 Signalling Pathway [0.03%]
Smilax glabra roxb.通过激活Nrf2/HO-1信号通路减轻小鼠顺铂诱导的急性肾损伤
Lin Zhao,Zengyaran Yue,Gang Wang et al.
Lin Zhao et al.
Background: Owing to its remarkable efficacy, cisplatin (CDDP) is widely used as a chemotherapeutic drug in clinical cancer treatment; however, its severe nephrotoxicity often leads to acute kidney injury (AKI), in turn a...
Aristolochic acid IVa ameliorates arthritis in SKG Mice by regulating macrophage polarization and Th17/Treg balance [0.03%]
通过调节巨噬细胞极化和Th17/Treg平衡， Aristolochic酸IVa改善SKG小鼠的关节炎
Qin-Wen Gao,Wei-Ying Liu,Mirza Jawad et al.
Qin-Wen Gao et al.
Background: Aristolochic acids (AAs)-containing herbs have been used as medicinal remedies for thousands of years. However, exposure to AAI and AAII increases the risk of nephropathy and cancers. Our previous study identi...