Artesunate attenuates skin hypertrophic scar formation by inhibiting fibroblast activation and EndMT of vascular endothelial cells [0.03%]
蒿甲醚通过抑制成纤维细胞激活和血管内皮细胞的EndMT来减轻皮肤增生性疤痕的形成
Ruo-Yu Shang,Jia-Cai Yang,Wen-Gang Hu et al.
Ruo-Yu Shang et al.
Background Hypertrophic scarring is an abnormal condition involving excessive fibroblast activation, aberrant extracellular matrix deposition, and persistent inflammation. Current treatments have limited efficacy and potential adverse effec...
10-Hydroxydec-2-enoic acid reduces vascular smooth muscle cell inflammation via interacting with Toll-like receptor 4 [0.03%]
10-羟基二十碳二烯酸通过与Toll样受体4相互作用来降低血管平滑肌细胞的炎症反应
Feng Jia,Yongqing Wang,Zhiqiang Chen et al.
Feng Jia et al.
Background: 10-Hydroxydec-2-enoic acid (10-HDA), a unique and marker compound in royal jelly, has a wide range of bio-activities. However, its role in regulating inflammation of vascular smooth muscle cell (VSMC), which i...
Morus alba L. alleviates influenza viral pneumonia. Evidences of its mechanism of action [0.03%]
白桑对缓解流感病毒性肺炎的作用及作用机制证据
Junsong Jing,Yi Sun,Yiyang Shui et al.
Junsong Jing et al.
Background: Viral pneumonia is an infection of the lungs caused by numerous different viruses, which can lead to severe respiratory distress and even life-threatening conditions. In the absence of specific treatments for ...
Edaravone dexborneol exerts anti-epileptic effects on rodent temporal lobe epilepsy by promoting NMDAR deactivation and inhibiting oxidative stress [0.03%]
埃达拉奉右莰醇通过促进NMDAR失活和抑制氧化应激对啮齿类前颞叶癫痫发挥抗癫痫作用
Wanhua Qiu,Roumeng Chen,Lechen Pan et al.
Wanhua Qiu et al.
Background: Disease-modifying treatments with anti-epileptic effects are currently unavailable and urgently required for temporal lobe epilepsy (TLE). Combined therapy targeting multiple mechanisms may offer a promising a...
Targeting GATA6 with pedunculoside inhibits fetal gene expression to attenuate pathological cardiac hypertrophy [0.03%]
用pedunculoside靶向GATA6以抑制胎儿基因表达从而减轻病理性心肌肥大
An Pan,Anqi Shi,Huanhuan Chen et al.
An Pan et al.
Background: Pathological cardiac hypertrophy is a characteristic feature of numerous cardiovascular diseases and significantly impacts human health. However, effective treatment options for cardiac hypertrophy are still s...
Guiqi Baizhu decoction enhances radiosensitivity in non-small cell lung cancer by inhibiting the HIF-1α/DNA-PKcs axis-mediated DNA repair [0.03%]
归芪白术饮通过抑制HIF-1α/DNA-PKcs轴介导的DNA修复增强非小细胞肺癌的放射敏感性
Yangyang Li,Gengqiang Yang,Qiyang Li et al.
Yangyang Li et al.
Background: Radiotherapy is one of the main treatments for non-small cell lung cancer (NSCLC), and radiosensitivity is a determinant of its efficacy. Therefore, enhancing the radiosensitivity is of great significance to i...
Liensinine overcomes EGFR-TKI resistance in lung adenocarcinoma through DRP1-mediated autophagy [0.03%]
Liensinine通过DRP1介导的自噬克服肺腺癌中的EGFR-TKI耐药性
Yuling Chen,Chenying Shu,Zhaowei Yan et al.
Yuling Chen et al.
Introduction: Persistent upregulation of autophagy contributes to tumour cells' resistance to EGFR-TKI therapy, and hence, inhibiting autophagy could be a valuable strategy for overcoming such resistance. ...
Ginsenoside CK inhibits EMT and overcomes oxaliplatin resistance in gastric cancer by targeting the PI3K/Akt pathway [0.03%]
人参皂苷CK通过作用于PI3K/Akt信号通路抑制胃癌的上皮细胞-间质转化及克服奥沙利铂耐药性
Li Zhang,Xiao-Lan Zhao,Zhang-Jing Cao et al.
Li Zhang et al.
Background: Gastric cancer remains a leading cause of cancer mortality, with oxaliplatin (L-OHP) resistance posing a major therapeutic challenge. Ginsenosides have shown potential in addressing chemoresistance. ...
Lactoferrin-modified organic-inorganic hybrid mesoporous silica for co-delivery of levodopa and curcumin in the synergistic treatment of Parkinson's disease [0.03%]
用于帕金森病协同治疗的左旋多巴和姜黄素共传递的铁蛋白修饰的有机-无机杂化介孔硅纳米材料
Xiuping Guo,Xubai Qiao,Xinru Li et al.
Xiuping Guo et al.
Background: Parkinson's disease (PD) is a chronic neurodegenerative disorder primarily characterized by oxidative stress and dopaminergic neuron damage. While levodopa remains the cornerstone of PD treatment, its efficacy...
Apigenin ameliorates inflamed ulcerative colitis by regulating mast cell degranulation via the PAMP-MRGPRX2 feedback loop [0.03%]
姚黄素通过病原相关分子模式-嗜碱性受体偶联反馈环路调节嗜碱性粒细胞脱颗粒从而改善炎症性溃疡性结肠炎
Yihan Huang,Na Wang,Xiaolan Ji et al.
Yihan Huang et al.
Purpose: The aim of this study was to investigate the therapeutic effect of API on UC via the regulation of PAMP-MRGPRX2-mediated mast cells (MCs) degranulation. ...