Multimodal discovery of bavachinin A: A natural FLT3 agonist for treating thrombocytopenia [0.03%]
巴伐酰胺A的多模态发现：一种用于治疗血小板减少症的天然FLT3激动剂
Long Wang,Ting Zhang,Xin Yang et al.
Long Wang et al.
Background: Radiation-induced thrombocytopenia (RIT) poses a serious risk to patients with cancer undergoing radiotherapy and leads to hemorrhage and mortality. Unfortunately, effective treatment options for RIT are curre...
Guttiferone E from Brazilian red propolis inhibited wound-isolated methicillin-resistant Staphylococcus aureus and enhanced the bactericidal action of suppressed macrophages [0.03%]
来自巴西红蜂胶的Guttiferone E抑制了伤口分离出的耐甲氧西林金黄色葡萄球菌并增强了受抑制巨噬细胞的杀菌作用
Nicolas Ripari,Emilly Camargo Lopes,Áleff Ferreira Francisco et al.
Nicolas Ripari et al.
Background: Propolis has been traditionally used to treat inflammatory and infectious diseases, and it is still used and researched worldwide. Methicillin-resistant Staphylococcus aureus (MRSA) may cause invasive infectio...
Effective compound combination of Bufei Yishen formula ameliorates PM2.5-induced COPD by inhibiting mitochondrial oxidative stress through SIRT3-mediated FOXO3 deacetylation [0.03%]
益肺养身方有效组方通过SIRT3介导的FOXO3去乙酰化抑制线粒体氧化应激，改善PM2.5诱导的COPD
Jing Wang,Huiyu Yue,Yangzi Dong et al.
Jing Wang et al.
Background: Fine particulate matter (PM2.5) exposure significantly contributes to the development of chronic obstructive pulmonary disease (COPD). However, the underlying mechanisms remain inadequately elucidated, and the...
Liang-Ge-San attenuates virus-induced acute lung injury by targeting FXR-mediated ACE2 downregulation to modulate the formation of the cytokine storm [0.03%]
梁 gettext-三通过下调FXR介导的ACE2的表达来调控细胞因子风暴的形成，从而减轻病毒诱导的急性肺损伤功效的研究
Liling Yang,Xiangjun Zhou,Junshan Liu et al.
Liling Yang et al.
Background: Traditional Chinese medicine has been recognized for its significant role in treating acute lung injury (ALI) due to its distinct therapeutic advantages. Liang-Ge-San (LGS), a formulation from the ancient "Tai...
Huangqi and Danshen improve the chronic nephrotoxicity of cyclosporin A by regulating lipid metabolism [0.03%]
黄芪和丹参通过调节血脂代谢减轻环孢素A的慢性肾毒性
Ran-Ran Gao,Cong Han,Gui-Yuan Sui et al.
Ran-Ran Gao et al.
Background: The clinical application of cyclosporine A (CsA) is limited due to nephrotoxicity. Lipid metabolism disorders play important roles in renal injury, but their role in CsA nephrotoxicity is not yet clear. Huangq...
Poncirin ameliorates alcoholic liver injury by regulating lipid metabolism and inflammatory response in a PPARα dependent manner [0.03%]
Poncirin通过PPARα依赖的方式调节脂质代谢和炎症反应，从而改善酒精性肝损伤
Jiawen Huang,Kaili Zhou,Jiayu Li et al.
Jiawen Huang et al.
Background: Poncirin (PO) is a citrus flavonoid with various of functional effect including cardiac ischemia-reperfusion injury, colitis, cancer, et al. Considering the role of PO in improving inflammation and lipid metab...
Raspberry ameliorates renal fibrosis in rats with chronic kidney disease via the PI3K/Akt pathway [0.03%]
树莓通过PI3K/Akt信号通路改善慢性肾病大鼠的肾脏纤维化
Jingjing Hu,Xingyuan Pang,Xiao Liang et al.
Jingjing Hu et al.
Background: Renal fibrosis is a hallmark of chronic kidney disease (CKD). In traditional Chinese medicine, Rubus chingii Hu (raspberry) is believed to have kidney-tonifying properties. However, whether raspberry can effec...
Qi-Huang decoction alleviates DSS-induced colitis with Candida albicans dysbiosis by enhancing innate immune response through Dectin-1-associated signaling [0.03%]
祁黄 decoction通过Dectin-1相关信号传导途径增强先天免疫反应，从而缓解DSS诱导的念珠菌性结肠炎 Albicans失调
Chengcheng Liu,Liu Yang,Zixu Wang et al.
Chengcheng Liu et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory disease of the gastrointestinal tract. Candida albicans, a common commensal fungus in the human gut, has been increasingly implicated in UC pathogenesis. Qi-Hu...
Piperlongumine alleviates viral myocarditis by inhibiting pyroptosis through NF-κB pathway [0.03%]
长椒素通过NF-κB通路抑制焦亡从而缓解病毒性心肌炎
Hui Li,Min Wang,Zhengdong Hua et al.
Hui Li et al.
Background: Viral myocarditis (VMC) is a cardiac condition characterized by inflammation of the myocardium due to viral infection. It is a significant cause of sudden cardiac death in young adults, and effective treatment...
Natural products alleviate atrial fibrillation by modulating mitochondrial quality control [0.03%]
天然产物通过调节线粒体质量控制来缓解心房颤动
Teng Ge,Rongjun Zou,Miao Zhang et al.
Teng Ge et al.
Background: Atrial fibrillation (AF), one of the most common cardiac arrhythmias, is associated with high mortality rates and significant healthcare burdens. Mitochondrial homeostasis has recently emerged as a critical fa...