Xiaochaihutang ameliorates depression-like behaviors induced via chronic social defeat stress by regulating exon-specific Bdnf transcription through H3K18 acetylation in the hippocampus of mice [0.03%]
小柴胡汤通过调控海马体中H3K18乙酰化介导的特异性Bdnf转录改善由慢性社交挫败压力引起的类抑郁行为
Fan Wang,Ziming Li,Boru Li et al.
Fan Wang et al.
Introduction: Depression is a prevalent and persistent mental disease characterized by symptoms such as anhedonia, anxiety, and desperation. Although our previous study shows that Xiaochaihutang (XCHT) upregulates hippoca...
Sauchinone preserves cardiac function in doxorubicin-induced cardiomyopathy by inhibiting the NLRP3 inflammasome [0.03%]
Sauchinone通过抑制NLRP3炎性体保留由多柔比星诱导的心肌病的心脏功能
Wenxu Xin,Hai Yang,Xinyu Heng et al.
Wenxu Xin et al.
Background: Doxorubicin (Dox)-induced cardiomyopathy (DIC) is characterized by severe myocardial damage that can progress to dilated cardiomyopathy and potentially lead to heart failure. No effective prevention or treatme...
Brazilin reduces methicillin-resistant Staphylococcus aureus virulence and pathogenicity by decreasing the secretion of the α-hemolysin [0.03%]
巴西棕榈仁通过减少α-溶血素的分泌降低金黄色葡萄球菌的毒力和致病性
Mingzhe Li,Zhengyuan An,Mengfei Yu et al.
Mingzhe Li et al.
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a super-resistant bacterium with strong pathogenicity, causing broad range of infections in various tissues. α-Hemolysin (Hla) is the main virulence facto...
Shenqi granules enhance recovery from cerebral ischemia-reperfusion injury by modulating tryptophan and tyrosine metabolism and activating NFE2L2/NRF2 [0.03%]
参芪颗粒通过调节色氨酸和酪氨酸代谢以及激活NFE2L2/NRF2来促进脑缺血再灌注损伤的恢复
Hai-Xin Liu,Ming-Kuan Yang,Yu-Chang Li et al.
Hai-Xin Liu et al.
Background: Stroke is a multifaceted physiological event linked to imbalances in gut microbiota and disruptions in metabolic pathways. Traditional Chinese medicines, leveraging the gut-brain axis, have been shown to signi...
Cirsium japonicum leaf extract attenuated lipopolysaccharide-induced acute respiratory distress syndrome in mice via suppression of the NLRP3 and HIF1α pathways [0.03%]
Cirsium japonicum叶提取物通过抑制NLRP3和HIF1α途径减轻小鼠内毒素引起的急性呼吸窘迫综合征
Eun Yeong Lim,Gun-Dong Kim,Ha-Jung Kim et al.
Eun Yeong Lim et al.
Background: Acute respiratory distress syndrome (ARDS) is a severe inflammatory disorder characterized by acute respiratory failure, alveolar barrier dysfunction, edema, and dysregulated alveolar macrophage-mediated pulmo...
JiGuCao capsule formula alleviates metabolic fatty liver disease by regulating the gut-liver axis and lipid metabolism [0.03%]
基于调节肝肠轴和脂质代谢， JiGuCao胶囊配方缓解了代谢性脂肪肝疾病
Wenying Qi,Xu Cao,Yue Chen et al.
Wenying Qi et al.
Background: Metabolic-associated fatty liver disease (MAFLD) is a prevalent chronic liver condition globally, characterized by suboptimal treatment outcomes. Traditional therapies often fail to address the multifaceted pa...
Reshaping the gut microbiota: Tangliping decoction and its core blood-absorbed component quercetin improve diabetic cognitive impairment [0.03%]
重塑肠道菌群：唐丽萍汤及其核心吸收成分檞皮素改善糖尿病认知障碍
Wenlan Zhang,Chunmei Yi,Zhijie Song et al.
Wenlan Zhang et al.
Background: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cognitive decline, which can result in diabetic cognitive impairment (DCI). Recent studies have indicated that gut microbiota plays a sig...
A decade review on phytochemistry and pharmacological activities of Cynomorium songaricum Rupr.: Insights into metabolic syndrome [0.03%]
Cynomorium songaricum Rupr 的十年药用植物化学和药理活性研究：对代谢综合征的深入分析
Zhihao Liu,Qihao Li,Fu Zhao et al.
Zhihao Liu et al.
Background: Cynomorium songaricum Rupr. (CSR), a perennial herb with a rich history in traditional medicine, has demonstrated therapeutic potential against metabolic syndrome (MetS) through its active compounds, including...
Angelicin ameliorated ulcerative colitis through activating HDAC1-derived HIF-1α acetylation [0.03%]
Angelicin通过激活HDAC1衍生的HIF-1α乙酰化来改善溃疡性结肠炎
Haifan Liu,Dunfang Wang,Xue Feng et al.
Haifan Liu et al.
Background: Ulcerative colitis (UC) is a stubborn disease that occurs globally. SSP-TXYF is a traditional Chinese medicine (TCM) compound, which is widely used in the treatment of UC, but its picking and preparation is co...
Intestinal 8 gingerol attenuates TBI-induced neuroinflammation by inhibiting microglia NLRP3 inflammasome activation in a PINK1/Parkin-dependent manner [0.03%]
肠内八角姜醇通过抑制微胶质细胞的PINK1/Parkin依赖性NLRP3炎症小体活化减轻TBI引起的神经炎症
Xuheng Tang,Lin Huang,Weiquan Ma et al.
Xuheng Tang et al.
Background: traumatic brain injury (TBI) is irreversible brain damage, leading to inflammation and cognitive dysfunction. Microglia involved in the inflammatory response after TBI. The gut microbiota, known as the body's ...