Schisandra total lignans ameliorate neuronal ferroptosis in 3xTg-AD mice via regulating NADK/NADPH/GSH pathway [0.03%]
五味子总木脂素通过调节NADK/NADPH/GSH通路改善3xTg-AD小鼠的神经细胞铁死亡
Yuying Wu,Mengying Wei,Mengyao Wang et al.
Yuying Wu et al.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited treatments. Schisandra total lignans (STL), the primary active component of Schisandra chinensis, shows potential in alleviatin...
Artemetin targets the ABCG2/RAB7A axis to inhibit mitochondrial dysfunction in asthma [0.03%]
阿泰美汀通过靶向ABCG2/RAB7A轴来抑制哮喘中的线粒体功能障碍
Ningpo Ding,Qiaoyun Bai,Zhiguang Wang et al.
Ningpo Ding et al.
Background: Artemetin, a natural flavonoid, is well-known for its significant anti-inflammatory and antioxidant properties, but its mechanisms in asthma are still unclear. ...
Stachydrine hydrochloride reduces NOX2 activity to suppress oxidative stress levels to improve cardiac insufficiency [0.03%]
毛喉子氯化物通过降低NOX2活性来抑制氧化应激水平以改善心脏功能不全
Mengwei Fu,Shuting Guo,Songru Yang et al.
Mengwei Fu et al.
Background: Oxidative stress is a significant cause in the occurrence of cardiac insufficiency. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase2 (NOX2)-derived reactive oxygen species (ROS) play a pivotal role...
Enhancing temozolomide efficacy in GBM: The synergistic role of chuanxiong rhizoma essential oil [0.03%]
川芎嗪能否提高胶质母细胞瘤中替莫唑胺的疗效？
Gang Ke,Pengyi Hu,Hui Xiong et al.
Gang Ke et al.
Background: Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis. Temozolomide (TMZ), the standard first-line chemotherapy drug is limited by severe toxicity and the development of drug r...
Herbal-based Xuebijing injection ameliorated vascular endothelial dysfunction via inhibiting ACLY/MYB/RIG-I axis in sepsis-associated lung injury [0.03%]
基于草本的Xuebijing注射液通过抑制ACLY/MYB/RIG-I轴改善脓毒症相关性肺损伤的血管内皮功能障碍
Jiayin Cui,Yunxin Deng,Xuechuan Li et al.
Jiayin Cui et al.
Background: Excessive endothelial pro-inflammatory response is an early hallmark of sepsis-induced acute lung injury (ALI). Xuebijing (XBJ), a traditional Chinese medicine, is widely used in clinical practice to treat sep...
Integrative gut microbiota, metabolomics and proteomics studies unraveled the mechanism of Shaoteng decoction in treating Sjogren's syndrome [0.03%]
整合肠道菌群、代谢组学和蛋白质组学研究揭示少藤汤治疗干燥综合症的机制
Fengtao Pang,Quan Jiang,Kesong Li et al.
Fengtao Pang et al.
Background: Sjögren's syndrome (SS) is a complicated autoimmune disorder, encompassing multifaceted pathogenesis of inflammatory response, immune dysregulation and metabolic abnormalities. Shaoteng Decoction (STD) is a t...
β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor [0.03%]
β-离酮通过激活潜在的肿瘤抑制因子OR51E2来抑制结直肠肿瘤的发生与发展
Ji-Sun Kim,Sungyun Cho,Mi-Young Jeong et al.
Ji-Sun Kim et al.
Background: Olfactory receptors (ORs) are present in non-olfactory tissues and contribute to diverse biological roles beyond smell perception. Among them, OR51E2 has been associated with cancer biology, and its activator,...
The roles of algal polysaccharides in modulating tumor immune microenvironment [0.03%]
藻类多糖在调节肿瘤免疫微环境中的作用
Yinfeng Wu,Nan Jia,Jingyu Sun et al.
Yinfeng Wu et al.
Background: Polysaccharides from algae provide a range of biology and health benefits. Lately, there has been a significant interest in how algal polysaccharides affect the immune microenvironment around tumors. ...
Metabolomics based analysis reveals the therapeutic effects of Incarvillea arguta (Royle) Royle aqueous extract against alcohol-induced liver injury [0.03%]
代谢组学分析揭示了粗刺绿绒蒿水提取物对酒精性肝损伤的治疗效果
Zi-Ge Feng,Zang-Jia Geng,Qin Song et al.
Zi-Ge Feng et al.
Background: Alcohol-induced liver injury (ALI) poses a significant threat to global human health. The Chinese Yi medicine Liangtoumao (LTM), which originated from the whole plant of Incarvillea arguta Royle (Royle), has b...
Neuroprotective role of geniposide-loaded UMSC nanovesicles in depression via P2ry12 downregulation [0.03%]
通过P2ry12下调色苷酸负载的UMSC纳米囊泡在抑郁症中的神经保护作用
Guoxiang Duan,Tianyu Zou,Xue Wu et al.
Guoxiang Duan et al.
Background: Depression is a prevalent mental disorder characterized by persistent low mood, loss of interest, and cognitive impairment. Oxidative stress and inflammation play crucial roles in its pathogenesis. Novel thera...