Cinobufagin overcomes bortezomib resistance in multiple myeloma strains by targeting SEC62/TRPM4-mediated NECSO [0.03%]
秦艽碱甲通过SEC62/瞬时受体电位M4介导的NECES化解多发性骨髓瘤细胞硼替佐米耐药性
Zhao Yin,Guangchao Li,Qi Zhong et al.
Zhao Yin et al.
Background: Necrosis by sodium overload (NECSO) is a poorly understood, novel form of cell death implicated in cancer. TRPM4 is the only protein currently linked to NECSO and is downregulated in bortezomib-resistant multi...
Investigating the biosynthesis pathways and hypolipidemic mechanisms of monacolin K in Monascus species [0.03%]
红曲霉单端孢霉菌素K生物合成途径及降脂机制研究
Ying Zheng,Yueting Zheng,Zirui Huang et al.
Ying Zheng et al.
Background: Metabolic syndrome (MetS) encompasses a cluster of conditions, including atherosclerotic dyslipidemia, hypercholesterolemia, hypertension, hyperglycemia, impaired glucose homeostasis, and central obesity. The ...
MPEP ameliorates sepsis-associated delirium by modulating hippocampal mGluR5 signaling and pyramidal neuron excitability in mice [0.03%]
MPEP通过调节小鼠海马mGluR5信号传导和锥体神经元兴奋性来改善脓毒症相关(delirium)谵妄
Yun Li,Haibo Li,Shaowei Hou et al.
Yun Li et al.
Background: Delirium is a cerebral manifestation commonly seen in sepsis, known as sepsis-associated delirium (SAD), and is thought to be closely related to excitatory nervous system disorders. Metabotropic glutamate rece...
Compound Kushen Injection suppresses multiple myeloma progression via TOP1-targeted coordination of DNA damage and endoplasmic reticulum stress [0.03%]
复方苦参注射液通过TOP1靶向协调DNA损伤和内质网应激抑制多发性骨髓瘤进展
Guopeng Chen,Ruihang Li,Xiqin Tong et al.
Guopeng Chen et al.
Background: Multiple myeloma (MM) is a plasma cell malignancy that remains incurable due to inevitable relapse and poor treatment tolerance. Compound Kushen Injection (CKI), a traditional Chinese medicinal formulation, ha...
Identification of Asari Radix et Rhizoma derived from three close Asarum species using the complete chloroplast genome [0.03%]
基于完整叶绿体基因组鉴别三种细辛药材的来源物种研究
Lu Li,Wei Sun,Mofan Zhang et al.
Lu Li et al.
Background: Asari Radix et Rhizoma is a traditional Chinese herbal medicine derived from Asarum sieboldii, Asarum heterotropoides var. mandshuricum and Asarum sieboldii var. seoulense. However, the three Asarum species ar...
Chinese herbal formula Huoxiang Zhengqi Qral liquid for atopic dermatitis: The CHARM randomized controlled trial [0.03%]
霍香正气口服液治疗特应性皮炎：CHARM随机对照试验研究
Meiling Xuan,Xiaohui Guo,Geng Li et al.
Meiling Xuan et al.
Background: There is an unmet treatment need and a lack of efficacy evidence for Huoxiang Zhengqi (HXZQ) oral liquid for atopic dermatitis (AD). Objective...
Elucidating the therapeutic mechanisms of resveratrol in benign prostatic hyperplasia via an integrated strategy of network pharmacology, multi-omics and molecular biology [0.03%]
网络药理学、多组学和分子生物学相结合阐明白藜芦醇治疗良性前列腺增生的机制
Jinze Li,Yin Huang,Bo Chen et al.
Jinze Li et al.
Background: Benign prostatic hyperplasia (BPH) is a prevalent age-associated urological disorder marked by excessive proliferation of epithelial and stromal cells within the prostate. Resveratrol (Res), a naturally occurr...
Decoding the lactylation landscape: Implications for tumor microenvironment remodeling and marine algal saccharide-based therapeutic interventions [0.03%]
乳酰化景观的解码：对肿瘤微环境重塑及海洋藻类糖缀合物疗法的影响
Yusong Qiu,Jiahui Wen,Nan Jia et al.
Yusong Qiu et al.
Background: Lactylation is the reversible post-translational modification where lactyl groups-metabolic products of lactic acid-covalently bind to lysine residues on proteins. This process is precisely regulated by "writi...
Celastrol ameliorates metabolic dysfunction associated steatohepatitis by regulating the CYP7B1-mediated alternative bile acid synthetic pathway [0.03%]
雷公藤素通过调节CYP7B1介导的胆汁酸合成旁路改善代谢失常相关性脂肪肝病
Meifen Hu,Jingtao Yang,Yuxuan Chen et al.
Meifen Hu et al.
Background: Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease driven by steatosis, inflammation, and fibrosis. Celastrol (CEL), a natural bioactive compound, has exhibited promise in p...
Hyperacmotone A alleviates Non-alcoholic Steatohepatitis via regulating PPARα signaling [0.03%]
通过调节PPARα信号通路缓解非酒精性脂肪肝病
Yueyou Yang,Ping Ying,Ziwei Jia et al.
Yueyou Yang et al.
Background: Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD), which is often accompanied by lipid metabolism disorders and mitochondrial dysfunction. Peroxisome proli...