Deciphering the core antiviral mechanism of Yinqiao powder: Inhibition of dengue virus adsorption mediated by wogonin via host receptor HSP90AA1 blockade [0.03%]
银翘散核心抗病毒机制解析：黄芩素通过拮抗宿主受体HSP90AA1抑制登革病毒吸附作用
Zhuolin Guo,Xuemei He,Bing Chen et al.
Zhuolin Guo et al.
Objective: Dengue virus (DENV) remains a significant public health threat, yet no effective antiviral therapies are currently available. Based on TCM theory, the treatment of dengue emphasizes the principles of clearing h...
Rhynchophylline inhibits cluster of differentiation 36 (CD36) on endothelial cells to reduce fibrotic scar formation and enhance functional recovery after spinal cord injury [0.03%]
钩藤碱通过抑制内皮细胞分化抗原36(CD36)的表达减少胶质瘢痕形成促进脊髓损伤后功能恢复
Manjeet Chopra,Nidhi Singh,Meenal Verma et al.
Manjeet Chopra et al.
Background: Spinal cord injury (SCI) causes severe neurological deficits due to extensive neurodegeneration and secondary pathological events, including disruption of the blood-spinal cord barrier (BSCB). Restoration of e...
Epigallocatechin gallate alleviates hyperhomocysteinemia by regulating methionine metabolism and epigenetic homeostasis in Drosophila melanogaster [0.03%]
表没食子儿茶素没食子酸酯通过调节果蝇甲硫氨酸代谢和表观遗传稳态来缓解高同型半胱氨酸血症
Yuxuan Zhao,Jingyimei Liang,Jesus Simal-Gandara et al.
Yuxuan Zhao et al.
Objectives: Hyperhomocysteinemia (HHcy) is characterized by disrupted methionine and one-carbon metabolism. Although epigallocatechin gallate (EGCG) can lower homocysteine levels, how it regulates methionine metabolism in...
Immunoregulatory mechanisms underlying vitexin-mediated attenuation of concanavalin A-induced liver injury [0.03%]
Vitexin通过免疫调节机制缓解ConA诱导的肝损伤的作用及机制研究
Qingmiao Shi,Yuting He,Huiwu Xing et al.
Qingmiao Shi et al.
Background: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disorder driven by dysregulated lymphocyte activation, yet current immunosuppressive therapies are often limited by severe side effects. Vitexin, a na...
Direct TNF-α targeting by Periploca forrestii-derived compounds confers anti-rheumatoid arthritis activity [0.03%]
来源于福寿草的直接针对TNF-α的成分具有抗类风湿作用
Yuan Lu,Weina Xue,Xudong Tian et al.
Yuan Lu et al.
Objective: Periploca forrestii Schltr. (PF), traditionally used by the Miao ethnic group in China, has been reported to exert a therapeutic effect on rheumatoid arthritis (RA), potentially through regulating of the TNF-α...
Efficacy and safety of Breviscapine injection combined with conventional therapy for unstable angina pectoris: A meta-analysis of randomized control trials [0.03%]
天舒注射液联合常规治疗不稳定性心绞痛的疗效和安全性：系统评价和-meta分析研究
Yunzi Liu,Keyan Chai,Meiling Guo et al.
Yunzi Liu et al.
Background: To systematically evaluate the efficacy and safety of Breviscapine injection as an adjunct to conventional Western medicine therapy for treating unstable angina pectoris (UAP). ...
Lycorine suppresses DPP3-mediated Nrf2 signaling, thereby reducing SLC7A11 levels to trigger ferroptosis in colorectal cancer cells [0.03%]
石蒜碱通过抑制DPP3介导的Nrf2信号传导降低SLC7A11水平从而诱导结直肠癌细胞铁死亡
Juan Sheng,Qixian An,Fubing Yu et al.
Juan Sheng et al.
Background: Colorectal cancer (CRC) exhibits high morbidity/mortality with poor late-stage survival, creating an urgent need for effective therapies. Although lycorine, a pyrrolophenanthridine alkaloid isolated from the t...
Nuangong Tiaojing Formula ameliorates luteal phase defect by restoring ovarian-uterine axis function via regulating inflammatory-apoptotic cascade [0.03%]
暖宫调经汤通过调控炎性凋亡级联恢复卵巢子宫轴功能治疗黄体期缺陷
Mingqian Hao,Xi Xue,Yinjia Li et al.
Mingqian Hao et al.
Background: Luteal phase defect (LPD) is a prevalent endocrine disorder contributing significantly to female infertility and early pregnancy loss. Nuangong Tiaojing Formula (NTF), a traditional Chinese medicine formula, h...
Spatiotemporal dynamics of morphology-metabolism interplay in Scutellaria baicalensis hollow root morphogenesis via spatially resolved metabolomics [0.03%]
基于空间分辨代谢组学的 Baicalin 植物空心根形态生成中形态与代谢时空动态相互作用机制研究
Guanhua Zhang,Chenglong Sun,Sheng Wang et al.
Guanhua Zhang et al.
Background: Understanding the morphogenetic processes and their spatial crosstalk with metabolism is essential for improving the quality of medicinal plants and constructing the regulation of the metabolite network. Howev...
Shenfu injection ameliorates coagulopathy in sepsis-associated liver injury via dual inhibition of endothelial cell pyroptosis [0.03%]
参附注射液通过抑制内皮细胞焦亡改善脓毒症相关肝损伤患者的凝血功能失调
Liya Gao,Yunxin Deng,Luyao Wang et al.
Liya Gao et al.
Background: Sepsis-associated liver injury (SALI) as a critical factor contributing to high mortality rates in patients with sepsis is characterized by significant coagulation disorders. Vascular endothelial cells (ECs) p...