TaoHeChengQi Decotion alleviate chronic renal failure via regulation of PHD2/UCP1 and RIPK3/AKT/TGF-β pathway [0.03%]
陶河成气汤通过调节PHD2/UCP1和RIPK3/AKT/TGF-β通路缓解慢性肾衰竭
Wei Liu,Cheng Hu,Xiaojing Qian et al.
Wei Liu et al.
Ethnopharmacological relevance: Chronic renal failure (CRF) is a late stage in the development of chronic kidney disease (CKD). Currently, there are no specific clinical drugs available. Traditional Chinese medicine (TCM)...
Embelin improves alcoholic steatohepatitis in alcohol-associated liver disease via ATF6-mediated P2X7r-NLRP3 signaling pathway [0.03%]
Embelin通过ATF6介导的P2X7r-NLRP3信号通路改善酒精相关性肝病的酒精性脂肪性肝炎
Jin-Jin Zhang,Jiang-Tao Zhong,Wan-Ling Wang et al.
Jin-Jin Zhang et al.
Background: Alcohol-associated liver disease (ALD) manifests with impaired lipid metabolism and inflammation within the liver. Embelin (EB), a natural para-benzoquinone compound derived from the Embelia ribes Burm.f. has ...
Therapeutic efficacy of Xuebijing injection in treating severe acute pancreatitis and its mechanisms of action: A comprehensive survey [0.03%]
血必净注射液治疗重症急性胰腺炎的治疗效果及其作用机制：全面调查
Zhuo Chen,Rui Zheng,Huiru Jiang et al.
Zhuo Chen et al.
Background: Severe acute pancreatitis (SAP) is a life-threatening condition associated with high mortality and limited therapeutic options. Current management strategies focus on infection prevention, immune regulation, a...
Effective-compounds of Jinshui Huanxian Formula acts as an SRC inhibitor to inhibit HK2-mediated H3K18 lactation and improve pulmonary fibrosis [0.03%]
金水换纤方的有效成分通过作为SRC抑制剂来抑制HK2介导的H3K18乳酸化并改善肺纤维化
Jiaping Zheng,Yan Du,Wenbo Shao et al.
Jiaping Zheng et al.
Background: The Active Ingredient Composition of Jinshui Huanxian Formula (ECC-JHF) consists of five active ingredients: icariin, isoliquiritigenin, nobiletin, peimine, and paeoniflorin, which demonstrate notable therapeu...
Fangchinoline suppresses nasopharyngeal carcinoma progression by inhibiting SQLE to regulate the PI3K/AKT pathway dysregulation [0.03%]
Fang胆碱通过抑制SQLE调节PI3K/AKT通路失调从而抑制鼻咽癌进展
Jieyun Xie,Zexian Shi,Lingling Sun et al.
Jieyun Xie et al.
Background and purpose: Squalene epoxidase (SQLE), a key enzyme in cholesterol metabolism, remains underexplored in nasopharyngeal carcinoma (NPC). Additionally, the therapeutic potential of Fangchinoline, an alkaloid wit...
Theabrownins improve burn-induced kidney injury by increasing the levels of guanidinoacetic acid and fumaric acid [0.03%]
茶黄素通过增加瓜氨酸和富马酸的水平改善烧伤引起的肾损伤
You Gao,Changshun Han,Zhiyuan Chen et al.
You Gao et al.
Background: Burns are a common and serious health issue, with severe burn-induced acute kidney injury (AKI) being a major factor contributing to poor recovery and increased mortality in patients. Theabrownins (TBs), bioac...
Guizhi Fuling decoction protects against bone destruction via suppressing exosomal ERK1 in multiple myeloma [0.03%]
桂枝茯苓汤通过抑制多发性骨髓瘤中的外泌体ERK1来保护免受骨破坏
Manya Yu,Jie Zhang,Jiaqi Fu et al.
Manya Yu et al.
Background: Myeloma-related bone disease (MBD) is a common complication of multiple myeloma (MM) that deteriorates patients' quality of life and affects overall survival. Modulating the interaction between myeloma cells a...
Quercetin protected the gut barrier in ulcerative colitis by activating aryl hydrocarbon receptor [0.03%]
黄酮通过激活芳烃受体来保护溃疡性结肠炎的肠道屏障
Qiuzhu Wei,Haixu Jiang,Jia Zeng et al.
Qiuzhu Wei et al.
Background: Ulcerative colitis (UC) is characterized by abdominal pain and bloody diarrhoea and restoring the gut barrier is the core goal of UC treatment. Activation of aryl hydrocarbon receptor (Ahr) was reported to eff...
Berbamine alleviates neuropathic pain via suppressing spinal TMEM34/SGK1/FOXO3 axis [0.03%]
Berbamine通过抑制脊髓TMEM34/SGK1/FOXO3轴缓解神经病理性疼痛
Chang-Heng Yao,Zi-Meng Zhang,Shen Zhang et al.
Chang-Heng Yao et al.
Background: The pathologic mechanism of neuropathic pain (NP) is still not fully understood, and efficient and safe therapeutic options are limited. Purpo...
Naoqing formula alleviates cerebral ischemia/reperfusion injury induced inflammatory injury by regulating Csf3 mediated JAK/STAT pathway and macrophage polarization [0.03%]
脑清公式通过调节Csf3介导的JAK/STAT通路和巨噬细胞极化来缓解脑缺血/再灌注损伤引起的炎症损伤
Yujun Ye,Zhaowei Rao,Xuexin Xie et al.
Yujun Ye et al.
Background: Upon cerebral ischemia/reperfusion injury (CIRI), the brain tissue experiences excessive inflammatory responses, which fuel the activation of immune cells, thereby intensifying cellular damage and inflammatory...