Renshen Zhuye decoction ameliorates high-fat diet-induced obesity and insulin resistance by modulating gut microbiota and metabolic homeostasis [0.03%]
人参叶汤通过调节肠道微生物群和代谢稳态来改善高脂饮食引起的肥胖和胰岛素抵抗
Fei Luo,Jie Yang,Zhiping Song et al.
Fei Luo et al.
Background: Obesity, characterized by excessive adipose tissue accumulation, has become a global health challenge with rapidly increasing prevalence. It contributes significantly to metabolic disorders including insulin r...
Combined metabolomics and network pharmacology to elucidate the mechanisms of Huiyang Shengji decoction in treating diabetic skin ulcer mice [0.03%]
代谢组学与网络药理学联合阐释灰香圆生肌方治疗糖尿病皮肤溃疡的机制研究
Jia Chen,Baoquan Qu,Danyang Yang et al.
Jia Chen et al.
Background: Diabetic skin ulcer is a clinical disorder of glucose metabolism that has a long treatment period and is prone to recurrent episodes. Huiyang Shengji decoction (HYSJD) is an effective traditional Chinese medic...
Eupalinolide B targets DEK and PANoptosis through E3 ubiquitin ligases RNF149 and RNF170 to negatively regulate asthma [0.03%]
Eupalinolide B通过E3泛素连接酶RNF149和RNF170靶向DEK和PANoptosis来负调控哮喘
Qiaoyun Bai,Chongyang Wang,Ningpo Ding et al.
Qiaoyun Bai et al.
Purpose: We investigated the mechanism by which eupalinolide B (EB) regulates DEK protein ubiquitination and degradation, and its impact on DEK-mediated receptor-interacting protein kinase 1 (RIPK)-PANoptosis pathway in a...
Revealing the gastric protective mechanism of Physochlaina physaloides (L) G. Don. with clinical orientation: PPAR/NF-κB signalling pathway activation [0.03%]
Physochlaina physaloides (L) G. Don的胃保护机制的揭示：临床导向PPAR/NF-κB信号通路激活
Siqi Li,Wanze Feng,Dongxue Chen et al.
Siqi Li et al.
Background: Gastrointestinal diseases are global health issues. Current drugs for gastrointestinal diseases cause discomfort and toxicity; consequently, the use of traditional medicines and their extracts has gained atten...
Acacetin ameliorates pressure overload-induced cardiac remodeling by targeting USP10 and inhibiting maladaptive cardiomyocyte autophagy [0.03%]
乙酰乙酸通过靶向USP10和抑制不适应的心肌细胞自噬来改善由压力超负荷引起的心脏重塑
Gaoyuan Ge,Wei Zhao,Zhuen Zhong et al.
Gaoyuan Ge et al.
Background: Numerous drugs have been developed to meet the critical demand for treatments inhibiting cardiac remodeling following cardiovascular disease. Acacetin is a flavonoid with potential therapeutic effects against ...
LuQi formula ameliorates pressure overload-induced heart failure by regulating macrophages and regulatory T cells [0.03%]
卢芪方通过调节巨噬细胞和调节性T细胞来改善由压力超负荷引起的心力衰竭
Xinting Wang,Qian Liu,Peipei Cheng et al.
Xinting Wang et al.
Background: Inflammatory macrophages in failing myocardium secrete CCL17, which targets CCR4 in immunosuppressive Tregs and inhibits the intracellular second messenger ARRB2-mediated cardiac chemotaxis. Traditional Chines...
4-Hydroxyderricin attenuates ischemic brain injury and neuroinflammation by upregulating haptoglobin expression in microglia [0.03%]
4-羟基丁香素通过上调小胶质细胞中嗜酸性蛋白的表达来减轻缺血性脑损伤和神经炎症
Biying Ma,Wenqi Wang,Zhongxia Li et al.
Biying Ma et al.
Background: Angelica keiskei (Miq.) Koidz. is a traditional plant that is widely used in Asian countries because of its tonic, diuretic, and galactagogue properties. The chalcone compound 4-hydroxyderricin (4-HD), uniquel...
Huang-Lian-Jie-Du decoction inhibits CD4+ T cell infiltration into CNS in MCAO rats by regulating BBB [0.03%]
黄连解毒汤通过调节血脑屏障抑制MCAO大鼠CD4+T细胞向CNS浸润
Congai Chen,Changxiang Li,Xin Lan et al.
Congai Chen et al.
Background: Stroke, especially ischemic stroke (IS), represents a major global health challenge due to its high incidence, disability, mortality, recurrence, and economic impact. The limited therapeutic window for thrombo...
Corrigendum to "Notoginsenoside R1 alleviates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway through microbiota-gut-brain axis" [Phytomedicine 128 (2024) 155530] [0.03%]
《通过微生物群-肠-脑轴抑制TLR4/MyD88/NF-κB信号通路缓解脑缺血再灌注损伤》["Notoginsenoside R1 alleviates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway through microbiota-gut-brain axis" [Phytomedicine 128 (2024) 155530]一文的勘误]
Shuxia Zhang,Qiuyan Chen,Meiqi Jin et al.
Shuxia Zhang et al.
Xerophenone H, a naturally-derived proteasome inhibitor, triggers apoptosis and paraptosis in lung cancer [0.03%]
天然衍生的蛋白酶体抑制剂Xerophenone H在肺癌中触发凋亡和副凋亡
Wen-Yu Lyu,Jun Cao,Wei-Qing Deng et al.
Wen-Yu Lyu et al.
Background: Polycyclic polyprenylated acylphloroglucinols (PPAPs) characterized by unique chemical architectures, exhibit diverse pharmacological activities. Xerophenone H (XeH) is a PPAP extracted from the plant Garcinia...