Gastrodin prevents stress-induced synaptic plasticity impairment and behavioral dysfunction via cAMP/PKA/CREB signaling pathway [0.03%]
gastrodin通过cAMP/PKA/CREB信号通路预防压力引起的突触可塑性损伤和行为功能障碍
Zhihuang Zhao,Pei Liu,Haili Zhang et al.
Zhihuang Zhao et al.
Background: Chronic stress is widely recognized as a critical factor that impairs synaptic plasticity dependent brain function and behavior, contributing to the onset of depression and anxiety disorders, which subsequentl...
Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites [0.03%]
迪奥斯米通过抑制肠道上皮细胞的PANoptosis以及调节肠道微生物群和代谢物来缓解结肠炎
Cheng Tan,Zixuan Xiang,Shuo Wang et al.
Cheng Tan et al.
Background: Inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), is a chronic inflammatory disorder characterized by an unclear etiology, often linked to gut microbiota dysbiosis and immune dysregulatio...
Zipeng Zheng,Jun Hu,Dawei Sun et al.
Zipeng Zheng et al.
Background: Natural products have emerged as a critical focus in modern scientific research due to their structural diversity and therapeutic potential. Among these are natural organic cations-a distinct class of nitrogen...
Luteolin inhibits inflammation and M1 macrophage polarization in the treatment of Pseudomonas aeruginosa-induced acute pneumonia through suppressing EGFR/PI3K/AKT/NF-κB and EGFR/ERK/AP-1 signaling pathways [0.03%]
黄酮抑制绿脓杆菌诱导的急性肺炎中的炎症和M1型巨噬细胞极化通过抑制EGFR/PI3K/AKT/NF-κB和EGFR/ERK/AP-1信号路径治疗过程中起到的作用
Mengdi Gu,Zheng Pang
Mengdi Gu
Background: The opportunistic pathogen Pseudomonas aeruginosa primarily causes infections in immunocompromised individuals. Luteolin, a natural flavonoid, is widely present in plants, which exerts various pharmacological ...
Integrated network pharmacology and experimental validation to elucidate the mechanism of celastrol in mitigating sepsis-induced acute lung injury in mice [0.03%]
整合网络药理学和实验验证以阐明雷公藤内酯醇减轻小鼠脓毒症急性肺损伤的机制
Danli Zhu,Jinghan Zhang,Xiaochun Huang et al.
Danli Zhu et al.
Background: Sepsis is an acute, life-threatening condition that precipitates multiple organ failure, including acute lung injury (ALI), characterized by a complex pathophysiological process and elevated mortality rates. C...
Modified huangfeng decoction alleviates diabetic nephropathy by activating autophagy and regulating the gut microbiota [0.03%]
改黄蜂 decoction 通过激活自噬和调节肠道微生物群来缓解糖尿病肾病
Yinhua Ni,Wenlong Yang,Sisi Wang et al.
Yinhua Ni et al.
Background: Diabetic nephropathy (DN) is one of the complications with the highest mortality among diabetes patients and can lead to renal failure. Modified Huangfeng decoction (MHD) has been widely applied in the clinica...
The pathogenesis of hepatocellular carcinoma: ERK/ULK1/NCOA4-mediated inhibition of iron autophagy, and Epimedium extract targeted modulation of this pathway to treat hepatocellular carcinoma [0.03%]
肝细胞癌的发病机制：ERK/ULK1/NCOA4介导的铁自噬抑制及淫羊藿提取物对该途径的靶向调节以治疗肝细胞癌
Liying Han,Xiangmu Tian,Xinxin Yang et al.
Liying Han et al.
Background: The pathogenesis of hepatocellular carcinoma (HCC) is characterized by its complexity and diversity, involving processes such as glycolysis, autophagy, and cellular immunity. Notably, the role of ERK/ULK1/NCOA...
Ginkgo biloba leaf extract EGb 761® for the treatment of various diseases: Overview of systematic reviews [0.03%]
银杏叶提取物EGb 761® 在各种疾病治疗中的应用：系统评价概述
Katrin Pfuhlmann,Anna K Koch,Jost Langhorst
Katrin Pfuhlmann
Background: Ginkgo biloba leaf extract EGb 761® might have diverse therapeutic effects. Objective: We conducted an overview of systema...
Targeting neutrophil dysfunction in acute lung injury: Insights from active components of Chinese medicine [0.03%]
中药活性成分在急性肺损伤中针对中性粒细胞功能障碍的研究洞察
Saiya Ye,Lin Ma,Yannan Chi et al.
Saiya Ye et al.
Backgrounds: Acute lung injury (ALI) is a lethal condition characterized by uncontrolled pulmonary inflammatory responses, with high morbidity and mortality rates that pose a significant threat to patient health. The pers...