Anemarchalconyn, a natural alkyne ketone compound, inhibits HCC cell growth by suppressing Polθ and inducing synthetic lethality in Homologous recombination deficiency cells [0.03%]
安梅尔契康因通过抑制多聚酶θ诱导同源重组缺陷型肝癌细胞合成致死效应而发挥抗肝癌作用
Junnan Li,Wenwen Deng,Tianjie Zhou et al.
Junnan Li et al.
Background: Hepatocellular carcinoma (HCC) is a highly aggressive liver cancer with limited treatment options. Dysfunction of DNA damage response (DDR) genes, including Polθ and BRCA1, is implicated in HCC development an...
Bazibushen attenuates fibroblast senescence in silica-induced pulmonary fibrosis via FOXO1/PINK1/Parkin Axis [0.03%]
巴戟伸筋汤通过FOXO1/PINK1/Parkin轴抑制硅肺成纤维细胞衰老
Siyun Zhou,Lan Peng,Yue Wang et al.
Siyun Zhou et al.
Silicosis, an age-related disease, is still a heavy burden on global occupational health. Emerging evidence has revealed that targeting senescent cells may be a promising therapeutic strategy for silicosis. This study was designed to invest...
Diabetic wound healing breakthrough: theaflavin-3, 3'-digallate nanoparticles@hydrogel activates the TGF-β1/SMAD3 pathway [0.03%]
糖尿病伤口治疗新突破：Theaflavin-3,3'-digallate纳米粒@水凝胶激活TGF-β1/SMAD3通路
Xu Dong,Jianyin Miao,Ling Wu et al.
Xu Dong et al.
Background: Diabetes patients face an elevated wound infection susceptibility and delayed healing processes. Currently, no existing literature has reported on the effect and mechanism of theaflavin-3, 3'-digallate nanopar...
Mechanistic insights into the potentiation and toxicity mitigation of myocardial infarction treatment with salvianolate and ticagrelor [0.03%]
salvianolate和ticagrelor治疗心肌梗死增效及减毒的机制初探
Yan Wan,Ming-Hao Yuan,Xue Liang et al.
Yan Wan et al.
Background: Ticagrelor (TG), a first-line treatment for myocardial infarction (MI), is limited in its clinical application due to the risk of elevated uric acid (UA) levels. Salvianolate injection (SAL), an adjunctive the...
Oleic acid regulates CD4+ T cells differentiation by targeting ODC1-mediated STAT5A phosphorylation in Vogt-Koyanagi-Harada disease [0.03%]
油酸通过靶向ODC1介导的STAT5A磷酸化调节CD4+T细胞在VKH病中的分化
Weiting Liao,Ruixue Hu,Yan Ji et al.
Weiting Liao et al.
Background: Vogt-Koyanagi-Harada (VKH) is a multisystemic autoimmune disorder characterized by bilateral panuveitis frequently accompanied by neurologic manifestations. While metabolic dysregulation is increasingly recogn...
Ginsenoside Rc maintains sleep rhythm homeostasis by alleviating oxidative stress [0.03%]
人参皂苷Rc通过减轻氧化应激来维持睡眠节律稳态
Xuenan Chen,Xiuci Yan,Chenxu Jing et al.
Xuenan Chen et al.
Background: Sleep disorders significantly impact physical health and quality of life. However, the current treatment strategies have several limitations. Panax ginseng has been traditionally employed to calm the mind, but...
Dual effects of Korean red ginseng extract and its fractions on influenza A virus infectivity in lung-derived cell lines [0.03%]
朝鲜红参提取物及其组分对肺来源细胞系中流感病毒感染性的双向调节作用
Yevheniia Kharkivska,Dong Hoon Kim,Olha Shkel et al.
Yevheniia Kharkivska et al.
Background: Influenza infections are significantly affected by the genetics of the viruses and the cells they infect. Our previous studies showed that various influenza A subtypes uniquely infect different cell lines, off...
α-Hederin causes ferroptosis in triple-negative breast cancer through modulating IRF1 to suppress GPX4 [0.03%]
香荷苷通过调节IRF1抑制GPX4诱导三阴性乳腺癌发生铁死亡
Xue Wu,Lingli Jin,Disuo Ren et al.
Xue Wu et al.
Background: Breast cancer ranks first in the global incidence rate of cancer among women. Triple-negative breast cancer (TNBC) is considered to be the most dangerous type because of the lack of specific therapeutic target...
Ginkgo biloba Extract GBE50 ameliorates cerebrovascular dysfunction and cognitive impairment in a mouse model of Alzheimer's disease [0.03%]
从提取物GBE50看银杏内酯对阿尔茨海默病小鼠模型的脑血管功能障碍和认知障碍的改善作用
Ting Yu,Zijie Wei,Jing Wang et al.
Ting Yu et al.
Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder in which neurovascular unit (NVU) dysfunction plays a critical role. GBE50, a refined extract of Ginkgo biloba containing over 50 % total flavon...
Traditional Chinese medicine in chronic rhinosinusitis: Mechanisms and postoperative recovery [0.03%]
中医在慢性鼻窦炎中的应用：机制与术后恢复
Xi-He Zhang,Qing-Jia Sun,Li-Chun Zhao et al.
Xi-He Zhang et al.
Background: Chronic rhinosinusitis (CRS) is inflammation of the sinuses and nasal passages that lasts for >3 months. Its pathogenesis is complex, treatment is difficult, and it has multiple effects on patients. Although s...