Erianin alleviates doxorubicin-induced cardiotoxicity by activating the Keap1-Nrf2 signaling pathway [0.03%]
埃里安因通过激活Keap1-Nrf2信号通路缓解阿霉素引起的心脏毒性
Shiyao Kang,Huimin Li,Ming Li et al.
Shiyao Kang et al.
Background: Doxorubicin (DOX) has significant toxic side effects on cardiomyocytes, and existing preventive drug dexrazoxane has serious side effects. Therefore, in-depth research on drugs that can enhance the antitumor e...
Gusongan capsule enhances osteogenic differentiation to mitigate bone loss in ovariectomized rats via the TLR2/NF-κB pathway [0.03%]
补肾壮骨胶囊通过TLR2/ NF- κB信号通路增强卵形切除大鼠成骨分化以减少骨丢失
Lingfeng Zeng,Jinlong Zhao,Zhuoxu Gu et al.
Lingfeng Zeng et al.
Background: Osteoporosis (OP) is a metabolic bone disease characterized by reduced bone mass and impaired bone microstructure, leading to an increased risk of fractures. In this context, the Gusongan (GSA) capsule has gai...
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence [0.03%]
小檗碱型生物碱 Vaccarin 通过抑制 JNK-SAA2 通路干预软骨细胞衰老从而缓解骨关节炎的研究
Xin Gan,Jianwen Li,Yongqiao Jiang et al.
Xin Gan et al.
Background: Osteoarthritis is a chronic degenerative joint disease marked by chondrocyte senescence and extracellular matrix degradation. Vaccarin, a flavonoid with anti-inflammatory and antioxidant properties, has not be...
Zengmian Yiliu formula suppresses cell cycle in immune-rich ovarian cancer patient-derived organoids [0.03%]
zen霉岩遗留方抑制免疫丰富卵巢癌患者衍生器官样细胞周期
Qi Cao,Chunhui Cai,Chen Wang et al.
Qi Cao et al.
Background: Ovarian cancer, often diagnosed at advanced stages, has a 5-year survival rate below 50%, indicating a critical need for innovative treatments. The Zengmian Yiliu (ZMYL) formula, a Traditional Chinese Medicine...
Biochanin A mitigates colitis by inhibiting ferroptosis-mediated intestinal barrier dysfunction, oxidative stress, and inflammation via the JAK2/STAT3 signaling pathway [0.03%]
生物碱生物碱A通过JAK2/STAT3信号通路抑制铁死亡介导的肠屏障功能障碍、氧化应激和炎症从而缓解结肠炎
Beiying Deng,Kunpeng Wang,Haodong He et al.
Beiying Deng et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by intestinal barrier dysfunction, oxidative stress, and inflammation. Biochanin A (BCA) is a natural flavonoid found in various plants, k...
Fufang-Biejia-Ruangan tablet targeting both cancer-associated fibroblasts and tumor cells by HIPPO-PI3K/AKT cascades in intrahepatic cholangiocarcinoma treatment [0.03%]
用于肝内胆管癌治疗的复方鳖甲润肠通便汤通过Hippo-PI3K/Akt级联通路靶向癌症相关成纤维细胞和肿瘤细胞
Yanyu Xu,Xiang Li,Miao Cui et al.
Yanyu Xu et al.
Background: Intrahepatic cholangiocarcinoma (ICC) ranks second among primary liver cancers in terms of prevalence, characterized by poor prognosis and scarce therapeutic interventions. Fufang-Biejia-Ruangan tablet (BJRG),...
Mai-wei-yang-fei decoction protects against pulmonary fibrosis by reducing telomere shortening and inhibiting AECII senescence via FBW7/TPP1 regulation [0.03%]
Mai-wei-yang-fei decoction通过调节FBW7/TPP1减少端粒缩短和抑制AECII衰老从而防治肺纤维化
Jing Wang,Yang Zhao,Yun Wei et al.
Jing Wang et al.
Background: Pulmonary fibrosis (PF) is a fatal disease associated with ageing. The senescence of alveolar epithelial type II cells (AECIIs) can drive PF. Therefore, reducing AECII senescence is a promising treatment to pr...
Prunella vulgaris polyphenols alleviate liver injury-uveitis comorbidity by regulating acylcarnitine via the S100A9-PP2A-AMPK pathway [0.03%]
聚花过路黄多酚通过S100A9-PP2A-AMPK信号通路调节酰基肉碱从而缓解肝损伤相关性葡萄膜炎
Jingchen Xie,Suhui Xiong,Jiahui Yu et al.
Jingchen Xie et al.
Background: Liver injury and uveitis pose severe threats to human health. Owing to the close relationship of physiology and pathology between the liver and the eyes, cases in which both conditions occur simultaneously are...
Single-nucleus RNA sequencing and network pharmacology reveal the mediation of fisetin on neuroinflammation in Alzheimer's disease [0.03%]
单核RNA测序和网络药理学揭示了檞皮素在阿尔茨海默病中对神经炎症的介导作用
Tingting Cao,Peiling Liao,Jia Lu et al.
Tingting Cao et al.
Background: Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive function and memory. This study explores cellular subgroups in AD using single-nucleus RNA sequencin...
Discovery of the pharmacodynamic material basis of Danggui Buxue Decoction in the treatment of diabetic kidney disease based on lipidomics regulation [0.03%]
基于脂质组学调控探讨当归补血汤治疗糖尿病肾病的药效物质基础发现研究
Xu Wang,Jing Liu,Tingting Liu et al.
Xu Wang et al.
Background: Danggui Buxue Decoction (DBD) is a formula used for treating diabetic kidney disease (DKD). However, the pharmacodynamic material basis of DBD in DKD therapy remains unclear, hindering its industrial developme...