Multi-approach analysis reveals the mechanism by which Shugan Xiaozhi decoction protects against metabolic dysfunction-associated steatohepatitis [0.03%]
多管齐下分析揭示舒肝消脂方防治非酒精性脂肪肝病的作用机制
Shuai Wang,Ruili Du,Jiahui Liu et al.
Shuai Wang et al.
Background: Metabolic dysfunction-associated steatohepatitis (MASH) is a human health-threatening hepatic disease with limited treatment strategies. As a clinical Traditional Chinese Medicine compound for MASH, Shugan Xia...
Mulberry twig (Sangzhi) alkaloids induce pancreatic α-to-β-cell phenotypic conversion in type 2 diabetic mice [0.03%]
桑枝生物碱可通过α-β细胞转分化改善2型糖尿病小鼠病理症状
Jian Li,Dandan Wang,Fei Li et al.
Jian Li et al.
Background: Pancreatic β-cell regeneration represents a promising therapeutic strategy for diabetes, yet safe and effective treatments remain elusive. Pu...
Kaempferol targets Src to exert its chemopreventive effects on mammary tumorigenesis via regulation of the PI3K/AKT pathway [0.03%]
山柰酚通过调节PI3K / AKT途径针对Src以发挥其对乳腺肿瘤发生的化学预防作用
Pinghan Wang,Yu Ma,Xiaohui Rao et al.
Pinghan Wang et al.
Background: Breast cancer (BC) is a prevalent malignancy that poses significant risks to the health of women worldwide. The incidence and mortality rates of BC continue to be high, despite improvements in diagnosis and tr...
Scutellaria baicalensis Extracts Restrict Intestinal Epithelial Cell Ferroptosis by Regulating Lipid Peroxidation and GPX4/ACSL4 in Colitis [0.03%]
黄芩提取物通过调节肠炎肠道上皮细胞脂质过氧化和GPX4/ACSL4限制铁死亡
Jingyan Zhang,Bingyan Tan,Hong Wu et al.
Jingyan Zhang et al.
Background: Ferroptosis in colonic epithelial cells has been implicated in the development of ulcerative colitis (UC) and the accompanying gut leakage. Scutellaria baicalensis Georgi (Scu) is widely used herb medicine for...
Higenamine protects against doxorubicin-induced heart failure by attenuating ferroptosis via modulating the Nrf2/GPX4 signaling pathway [0.03%]
阿尼马宁通过调节Nrf2/GPX4信号通路来减轻鬼臼毒素诱导的心力衰竭及铁死亡损伤的作用与机制研究
Jianxia Wen,Lu Li,Dinglin Ou et al.
Jianxia Wen et al.
Background: Higenamine (HG), a benzylisoquinoline alkaloid in Aconiti Lateralis Radix Praeparata (ALRP), has cardioprotective effects. Prior research indicated its potential anti-heart failure (HF) function, yet the molec...
Atractylenolide-Ⅲ binds non-structural protein-1 to suppress influenza A by modulating macrophage polarization and alternative polyadenylation [0.03%]
苍术素-Ⅲ通过调节巨噬细胞极化和选择性多聚腺苷酸化抑制甲型流感病毒NS1蛋白功能
Jinlong Liang,Huiyi Guo,Yan Yang et al.
Jinlong Liang et al.
Background: Drug-resistant influenza demands novel antiviral treatments. Non-structural protein 1 (NS1) of influenza A virus (IAV) regulates the viral life cycle and host immune response, thus becoming a promising therape...
Enhancing curcumol delivery through PD-1 targeted nanocarriers: A novel therapeutic approach for prostate cancer [0.03%]
通过PD-1靶向纳米载体增强姜黄素衍生物curcumol的传递：前列腺癌治疗的新方法
Hao Zhang,Yang Du,Xujia Liu et al.
Hao Zhang et al.
Background: Prostate cancer is a prevalent form of cancer that impacts men on a global scale, and its treatment faces challenges such as tumor metastasis, immune resistance, and epigenetic abnormalities. Most current rese...
Add-on effect of curcumin to dienogest in patients with endometriosis: a randomized, double-blind, controlled trial [0.03%]
姜黄素联合地诺孕素治疗子宫内膜异位症患者的附加作用：随机双盲对照试验
Mahjoob Sargazi-Taghazi,Habib Ghaznavi,Roghayeh Sheervalilou et al.
Mahjoob Sargazi-Taghazi et al.
Background: Endometriosis is a chronic gynecological disorder characterized by significant pain and reduced quality of life (QOL). Current treatments, such as dienogest, are not fully effective, prompting the investigatio...
Buyang huanwu decoction (BYHWD) attenuates sepsis-induced myocardial injury by suppressing aberrant iron accumulation in preclinical mouse models [0.03%]
补阳还五汤通过抑制异常铁沉积减轻败血症小鼠心肌损伤
Lingling Xiao,Jun Lu,Meng Zhao et al.
Lingling Xiao et al.
Background: Sepsis-induced myocardial injury (SIMI), in particular, myocardial fibrosis, is frequently detected in septic patients and regarded as a key factor associated with sepsis-related mortality. ...
Kaempferol combats the osteogenic differentiation damage of periodontal ligament stem cells in periodontitis via regulating EphrinB2-mediated PI3K/Akt and P38 pathways [0.03%]
黄酮类化合物山柰酚通过调节EphrinB2介导的PI3K/Akt和P38信号通路对抗牙周炎中牙周膜干细胞成骨分化损伤
Jiao Cao,Yue Li,Mengying Si et al.
Jiao Cao et al.
Background: The osteogenic differentiation of periodontal ligament stem cells (PDLSCs) plays a fundamental role in endogenous bone regeneration during periodontitis treatment, yet achieving consistent differentiation unde...