Stevia rebaudiana root polysaccharide modulates liver metabolism, bile acid, and gut microbiota improving HFD-induced NAFLD: Potential roles of ACSL1 and FADS2 [0.03%]
圣草次苷叶甜菊根多糖可调节肝脏代谢、胆汁酸和肠道微生物群，改善HFD诱导的NAFLD：ACSL1和FADS2的潜在作用
Yulong Bao,Xiaolong Shang,Guangdong Hu et al.
Yulong Bao et al.
Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder characterized by liver lipid accumulation and insulin resistance. However, effective therapeutic drugs for NAFLD are currently unavai...
Withaferin A maintained microbiome and metabolome features in A53T transgenic mice via multi-omics integrated analysis [0.03%]
基于组学联合分析的 Withaferin A 对 A53T 模拟帕金森病小鼠肠道菌群及代谢组的影响研究
Xiaodong Sun,Bingqing Qin,Ai Guo et al.
Xiaodong Sun et al.
Background: Withaferin A (WFA), a naturally occurring compound, has shown promise as a therapeutic agent for Parkinson's disease (PD), a neurodegenerative disorder associated with motor and gastrointestinal dysfunctions. ...
Validated herbal extracts for alleviating chemotherapy-induced myelosuppression: A systematic review and meta-analysis [0.03%]
基于验证草药提取物缓解化疗所致骨髓抑制的系统评价和荟萃分析
De-Hui Wang,Xiao-Ni Ma,Yan Wang et al.
De-Hui Wang et al.
Background: Myelosuppression is a major side effect of chemotherapy. It impairs hematopoietic function of bone marrow, decreases immunity, increases uncontrolled bleeding. Advanced myelosuppression even forces discontinua...
Tetrahydrocurcumin alleviates colorectal tumorigenesis by modulating the SPP1/CD44 axis and preventing M2 tumor-associated macrophage polarization [0.03%]
姜黄素衍生物四氢姜黄素通过调控SPP1/CD44轴和防止M2型肿瘤相关巨噬细胞极化来抑制结直肠癌发生發展
Mengting Zhou,Rui Li,Guiyun Lian et al.
Mengting Zhou et al.
Background: Recent studies show that secreted phosphoprotein 1 (SPP1) is linked to the progression of various cancers, including colorectal cancer (CRC). SPP1 also promotes M2 macrophage polarization, contributing to immu...
6'-O-caffeoylarbutin attenuates D-galactose-induced brain and liver damage in aging mice via regulating SIRT1/NF-κB pathway [0.03%]
6-O-咖啡酰阿尔-butin通过调节SIRT1/NF-κB途径缓解D-半乳糖诱导的小鼠脑和肝损伤
Yongpeng Wang,Yongchao Wang,Tianrui Zhao et al.
Yongpeng Wang et al.
Background: Aging-related liver and brain damage caused by oxidative stress and inflammation significantly impacts health and quality of life. Natural bioactive compounds, such as 6'-O-caffeoylarbutin (CA), which is prima...
Berberine promotes hair growth by targeting Axin2 and activating Wnt/β-catenin pathway [0.03%]
小檗碱通过作用Axin2激活Wnt/β-联蛋白信号途径促进毛发生长
Ke Cheng,Jinran Lin,Mengyi Wu et al.
Ke Cheng et al.
Background: Androgenetic alopecia (AGA) is the most common type of hair loss, with high incidence of comorbidities such as polycystic ovary syndrome (PCOS), metabolic syndrome, insulin resistance and cardiovascular diseas...
Linghe granules reduces hepatic lipid accumulation in Non-alcoholic fatty liver disease through regulating lipid metabolism and redox balance [0.03%]
灵河颗粒通过调节脂质代谢和氧化还原平衡减少非酒精性脂肪肝的肝脏脂质蓄积
Yuting Hu,Ni&#x;ao Li,Rumian Zhang et al.
Yuting Hu et al.
Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent liver disorder with no approved pharmacological therapies. Linghe granules, a hospital-based formulation derived from a classic prescription, have demon...
Effectiveness and safety of Suhuang Zhike capsules in adults with asthma: A multicenter, randomized, double-blinded, placebo-controlled trial [0.03%]
舒肺止咳胶囊治疗成人哮喘有效性和安全性的多中心随机双盲安慰剂对照试验
Yilin Pan,Kaijun Chen,Wen Hua et al.
Yilin Pan et al.
Background: Suhuang Zhike (SHZK) Capsules are a traditional Chinese medicine formulation that are widely used to treat post-infectious cough. However, evidence supporting their efficacy in anti-asthmatic treatment and ast...
Integrating thermal proteome profiling and virtual screening to reveal the mechanism of Bletilla striata against osteoclast-driven osteoporosis [0.03%]
结合热蛋白质组分析和虚拟筛选揭示Bletilla striata抗破骨细胞驱动型骨质疏松症的机制
Guiyu Dai,Ying Yang,Wen Mu et al.
Guiyu Dai et al.
Background: Osteoclast (OC) overactivation and increased bone resorption are central factors contributing to osteoporosis (OP). Bletilla striata (Thunb.) Reichb. f. is known for its hemostatic properties, however, its the...
New insights into phytochemicals via protein glycosylation focused on aging and diabetes [0.03%]
基于蛋白质糖基化的植物化学研究新见解——聚焦衰老与糖尿病
Yihan Chen,Suyue Lu,Shuo Shan et al.
Yihan Chen et al.
Background: Protein glycosylation as a common post-translational modification that has significant impacts on protein folding, enzymatic activity, and interfering with receptor functioning. In recent years, with the rapid...