Wikstrol B reactivates latent human immunodeficiency virus (HIV-1) via the nuclear factor-κB (NF-κB) pathway [0.03%]
.wikstrol b通过核因子κb途径重新激活潜伏的获得性免疫缺陷综合征病毒(人类免疫缺陷病毒)
Ziyao Wu,Kang Ding,Wenli Liu et al.
Ziyao Wu et al.
Background: Combination antiretroviral therapy (cART) and latency-reversing agents (LRAs) have not achieved a successful cure of HIV infection, due to latent HIV reservoir for the former, and insufficient efficacy and adv...
Diosmin attenuates UUO-induced renal ferroptosis and fibrosis by inhibiting the HIF-1α/FABP4 signaling axis [0.03%]
染料木素通过抑制HIF-1α/FABP4信号轴缓解UUO诱导的肾铁死亡和纤维化
Wen-Man Zhao,Fan Chu,Jun-Xing Zhu et al.
Wen-Man Zhao et al.
Background and purpose: Renal fibrosis is a major pathological feature of chronic kidney disease (CKD) that poses significant therapeutic challenges owing to its irreversible nature. In this study, we aimed to investigate...
Spatially resolved multi-omics reveals the renal cortex-metabolic reprogramming of Shenhua Tablet for intervention on IgA nephropathy [0.03%]
空间分辨多组学揭示了肾小皮质代谢重组及 Shenhuawanshan 介入治疗免疫球蛋白 A 肾病的作用机制
Fengting Yin,Ping Li,Chang Liu et al.
Fengting Yin et al.
Background: Shenhua tablet (SHT) is a clinically used Chinese patent medicine, which has garnered attention for its effectiveness in treating IgA nephropathy (IgAN). Nevertheless, early researches lacked anatomical and me...
Tea polyphenol EGCG enhances the improvements of calorie restriction on hepatic steatosis and obesity while reducing its adverse outcomes in obese rats [0.03%]
茶多酚EGCG增强卡路里限制对肥胖大鼠肝脂肪变性和肥胖的改善作用的同时减少其不良后果
Guohuo Wu,Mengdi Wang,Zhaofeng Du et al.
Guohuo Wu et al.
Background: Currently, calorie restriction (CR) is popular among young people as a way to lose weight and prevent obesity. However, CR can also cause a series of side effects, such as weight regain after resuming free eat...
A tri-compound formula comprising Ginsenoside Rg1, tetrandrine and icariin alleviates atopic dermatitis symptoms in a mouse model [0.03%]
包含人参皂苷Rg1、四氢长春花碱和淫羊藿素的三联复方制剂可缓解小鼠模型的特应性皮炎症状
Ying Wu,Xiao-Qi Wang,Jia-Ying Wu et al.
Ying Wu et al.
Background: Atopic dermatitis (AD) is characterized by both IgE- and non-IgE-mediated immune responses, as well as skin barrier dysfunction. Ginsenoside Rg1, tetrandrine, and icariin each exhibit distinct properties that ...
Patchouli alcohol restores gut homeostasis in irritable bowel syndrome with diarrhea through myosin Va-mediated neurotransmitter regulation [0.03%]
PATCHOULI醇通过肌球蛋白Va介导的神经递质调节修复腹泻型肠易激综合征肠道稳态
Wanyu Chen,Ting Li,Yukang Lin et al.
Wanyu Chen et al.
Background: Patchouli alcohol (PA), the active ingredient of Pogostemonis Herba, is important in medicine and food, effectively alleviating irritable bowel syndrome with diarrhea (IBS-D) symptoms; however, its mechanism r...
Tanshinone IIA promotes ferroptosis in cutaneous melanoma via STAT1-mediated upregulation of PTGS2 expression [0.03%]
丹参酮IIA通过STAT1介导的PTGS2上调促进皮肤黑色素瘤铁死亡
Shuyue Chen,Peiting Li,Ke Shi et al.
Shuyue Chen et al.
Background: Melanoma is highly aggressive, metastatic with a poor prognosis. Despite significant advances in targeted therapies and immunotherapies, their efficiency limited by drug resistance. Tanshinone IIA (Tan IIA), a...
Curcumol Ameliorates Cisplatin-induced Nephrotoxicity by Targeting TAK1 and Inhibiting MAPK and NF-κB Pathways [0.03%]
姜黄素茋通过靶向TAK1和抑制MAPK及NF-κB信号通路改善顺铂引起的肾毒性
Xuejin Jin,Miao Yuan,Lingkun Wang et al.
Xuejin Jin et al.
Background: Although cisplatin (Cis) is a foundational chemotherapeutic agent, its dose-limiting nephrotoxicity lacks clinically effective drugs. Curcumol (CUR), a bioactive sesquiterpenoid derived from Curcuma zedoariae ...
Restorative mechanisms of Shugan Yiyang capsule on male infertility through 'pharmaco-metabo-net' tripartite correlation analysis [0.03%]
疏肝益阳胶囊治疗男性不育的修复机制探讨：“药-效-代谢”三重关联分析
Ying Shen,Jian Fan,Chunmei Li et al.
Ying Shen et al.
Background: Shugan Yiyang capsule (SGYY), a commonly used traditional Chinese medicine formulation, is primarily indicated for the treatment of erectile dysfunction, yet existing studies on the therapeutic effects on male...
Sophoraflavanone G as an ectosteric inhibitor of cathepsin K attenuates ovariectomy-induced bone loss by suppressing bone resorption [0.03%]
sophoraflavanone G通过抑制骨吸收来减轻卵巢切除术引起的骨质流失作为猫食蛋白K的细胞外受体拮抗剂
Xueling Hu,Chunxia Liu,Ziling Tang et al.
Xueling Hu et al.
Background: Cathepsin K (CTSK) is a key enzyme in bone resorption, making it a promising target for osteoporosis treatment. Active-site inhibitors of CTSK are effective but have undesirable side effects, while ectosteric ...