Juglone alleviates pelvic pain and prostatic inflammation via inhibiting the activation of NLRP3 inflammasome and alleviating oxidative stress in EAP mice [0.03%]
juglone通过抑制nlp3炎症小体的激活和缓解氧化应激来缓解eap小鼠的盆腔疼痛和前列腺炎
Wenlong Xu,Wenming Ma,Jiabin Yue et al.
Wenlong Xu et al.
Background: Juglone, a naphthoquinone compound that occurs naturally, is present predominantly in the fruits, leaves, and roots of walnut plants. Although its antioxidant and anti-inflammatory effects have been demonstrat...
Semen Ziziphi Spinosae alleviates cardiomyocyte apoptosis in rats with coronary heart disease via the AMPK/SIRT1/PGC-1α signaling pathway activation [0.03%]
刺五加种子通过激活AMPK/SIRT1/PGC-1α信号通路缓解冠心病大鼠心肌细胞凋亡
Anqi Bi,Rihong Liu,Min Xie et al.
Anqi Bi et al.
Background: Coronary heart disease (CHD) represents a significant cardiovascular condition, with its occurrence increasing as a result of alterations in lifestyle and dietary habits. Semen Ziziphi Spinosae (SZS) is common...
Mechanism elucidation and biochemometric-based screening of substances in Schisandra chinensis leaves for alcoholic liver injury [0.03%]
五味子叶防治酒精性肝损伤的机制阐释及化学计量学筛选活性成分研究
Yifan Bing,Xiang Zou,Xiaolong Yang et al.
Yifan Bing et al.
Background: Alcoholic liver injury (ALI) represents a major international public health concern with no targeted pharmacological intervention and a dearth of clinical trial-approved medications for its management. The dri...
Decoding gelsenicine-induced neurotoxicity in mice via metabolomics and network toxicology [0.03%]
基于代谢组学和网络毒理学的苯甲酰樟柳碱神经毒性作用机制研究
Jinxiao Zhai,Hui Yan,Minghao Liu et al.
Jinxiao Zhai et al.
Background: Gelsenicine, the most toxic constituent of Gelsemium elegans Benth., is known for its diverse pharmacological activities alongside potent neurotoxicity, frequently leading to poisoning incidents following mist...
Exochorda racemosa attenuates DSS-induced colitis in C57BL/6 J mice by regulating inflammatory factors, reducing oxidative stress, and modulating intestinal flora [0.03%]
白珠滇缺盆通过调节炎症因子、减少氧化应激及调控肠道菌群治疗DSS诱导的小鼠结肠炎
Sha Long,Lu Wang,Qi Zeng et al.
Sha Long et al.
Background: Exochorda racemosa is a member of the genus Exochorda in the Rosaceae family. Its tender leaves and buds are favored as a unique wild vegetable by people in central China. ...
Oleanolic acid inhibits M2 macrophage polarization and potentiates anti-PD-1 therapy in hepatocellular carcinoma by targeting miR-130b-3p-PTEN-PI3K-Akt signaling and glycolysis [0.03%]
oleanolic酸通过靶向miR-130b-3p-PTEN-PI3K-Akt信号传导和糖酵解抑制M2型巨噬细胞极化并增强肝癌抗PD-1疗法
Xiaoyu Tu,Wanfu Lin,Xiaofeng Zhai et al.
Xiaoyu Tu et al.
Background: Hypoxia promotes M2 polarization of macrophages and the formation of the immunosuppressive tumor microenvironment (TME) in hepatocellular carcinoma (HCC). Oleanolic acid (OA) has shown great potential in the t...
Protective effects of albiflorin on acetaminophen-induced hepatotoxicity: Regulation of blood-biliary barrier integrity by ATF3 [0.03%]
白花丹素对乙酰氨基酚致肝毒性的保护作用： ATF3调节血液胆汁屏障完整性
Musen Lin,Yue Wang,Yan Zhao et al.
Musen Lin et al.
Background: Acetaminophen-induced hepatotoxicity remains a clinical challenge with limited targeted therapeutic options. While recent advances have identified blood‒biliary barrier disruption as a critical pathogenic mec...
Natural alkaloids modulating macrophage polarization: Innovative therapeutic strategies for inflammatory, cardiovascular, and cancerous diseases [0.03%]
调节巨噬细胞极化的天然生物碱：用于炎症、心血管及肿瘤疾病的创新治疗策略
Jing Lu,Ying Zhou,Yi-Xuan Song et al.
Jing Lu et al.
Background: Macrophage polarization, switching between pro-inflammatory M1 and anti-inflammatory M2 states, is crucial for disease dynamics in inflammatory, metabolic, and cancer contexts. Modulating this polarization is ...
Formononetin attenuates myocardial ischemia/reperfusion injury by regulating neutrophil extracellular traps formation and platelet activation via platelet CD36 [0.03%]
黄芩素通过调节血小板CD36介导的中性粒细胞胞外陷阱形成及血小板活化减轻心肌缺血再灌注损伤
Shuang Tang,Jing-Xue Ye,Ruo-Yun Li et al.
Shuang Tang et al.
Background: Prothrombotic and proinflammatory responses are crucial in the pathology of myocardial ischemia-reperfusion injury (MIRI). Platelets and neutrophil extracellular traps (NETs) are essential to linking inflammat...
Glycoside components promote endothelial progenitor cell-derived exosomes repairing damaged vascular endothelium via the PI3K/AKT signaling pathway [0.03%]
糖苷组分通过PI3K/AKT信号通路促进内皮祖细胞来源的外泌体修复受损血管内皮细胞
Wei Tan,Lu Ma,Yanling Li et al.
Wei Tan et al.
Objective: This paper investigated the effects of three glycosides-astragaloside IV, amygdalin, and paeoniflorin (AAP)-derived from Buyang Huanwu Decoction combined with endothelial progenitor cell-derived exosomes (EPC-E...