Animal studies and AI-based analysis identify the efficacy of berberine to inhibit experimental abdominal aortic aneurysms [0.03%]
动物研究和基于人工智能的分析识别了小檗碱抑制实验性腹主动脉瘤的功效
Kangli Tian,Ruipu Tian,Longlong Qin et al.
Kangli Tian et al.
Background: Currently, no drug treatment is available for abdominal aortic aneurysms (AAAs). Berberine, an alkaloid extracted from the traditional Chinese herbs Coptis chinensis and Phellodendron amurense, has several ben...
Obacunone ameliorates high-fat diet-induced MAFLD by regulating the PPARγ-FABP1/CD36 axis and the gut-liver crosstalk [0.03%]
奥巴普肽通过调节PPARγ-FABP1/CD36轴和肠肝对话来改善高脂饮食引起的MAFLD
Xuewen Wang,Jiaming Hong,Rui Liang et al.
Xuewen Wang et al.
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a global health challenge with limited treatment options. Obacunone (Oba), a natural triterpenoid with anti-inflammatory and antioxidant properti...
In silico analysis-aided pharmacochemistry strategy to explore the pharmacodynamic material basis and mechanism of traditional Chinese medicine: Qingfei Mixture as a model [0.03%]
基于计算机辅助药效化学策略探讨经典名方“清肺排毒汤”功效物质基础及配伍机制研究
Xiaojiao Yi,Siqi Chen,Min Huang et al.
Xiaojiao Yi et al.
Background: Qingfei Mixture (QFM) is a traditional Chinese medicine (TCM) prescription that is clinically used as an adjuvant treatment for mid- and late-stage lung cancer. However, the pharmacodynamic material basis and ...
Formononetin, a bioactive isoflavone compound in modified nuanxinkang, alleviates cardiorenal syndrome type 4-induced mitochondrial dysfunction by targeting Hippo-YAP signaling [0.03%]
芒康改剂中的活性异黄酮成分formononetin通过靶向Hippo-YAP信号通路缓解心肾综合征4型引起的线粒体功能障碍
Meidan Yao,Ruijia Wen,Haowen Zhuang et al.
Meidan Yao et al.
Background: Cardiorenal syndrome type 4 (CRS4) arises from the chronic kidney disease, and currently, there is a lack of therapies specifically target the dual pathological mechanisms of CRS4, namely mitochondrial dysfunc...
The natural compound stachyose targets SGLT2-mediated metabolic reprogramming to ameliorate diabetic kidney disease [0.03%]
天然化合物鼠李糖四糖通过靶向SGLT2介导的代谢重编程改善糖尿病肾脏疾病
Yicai Wu,Yun Cao,Ling Feng et al.
Yicai Wu et al.
Background: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease with no curative treatment currently available. Aberrant metabolic reprogramming in renal tubular epithelial cells contributes to ren...
Potential saviour of pulmonary fibrosis: multi-pathway treatment of natural products [0.03%]
潜在的肺纤维症解方：天然产物多路径治疗
Yujia Weng,Baoli He,Jialin Zhou et al.
Yujia Weng et al.
Background: Pulmonary fibrosis (PF), a terminal manifestation of diverse interstitial lung diseases, remains incompletely understood in its pathogenesis. Natural products possess multifaceted biological activities and rel...
The total xanthones from Gentianella acuta alleviate acute myocardial infarction by targeting BRD4-mediated cardiomyocyte pyroptosis and inflammation [0.03%]
总番木鳖碱通过靶向BRD4介导的心肌细胞焦亡与炎症治疗急性心肌梗死
Cheng Dai,Jiahuan Sun,Gaoshan Yang et al.
Cheng Dai et al.
Background: Gentianella acuta (G. acuta), a traditional remedy for cardiovascular ailments among the Ewenki people of China, has been reported to contain xanthones as its primary bioactive components. However, the complet...
Genistein ameliorates thoracic aortic dissection by inhibiting CB1 receptor hyperactivation and modulating its-mediated cAMP-PKA signaling [0.03%]
染料木素通过抑制CB1受体过度活化及其介导的cAMP-PKA信号通路改善胸主动脉夹层
Yanbang Chi,Tao Huang,Jikai Zhao et al.
Yanbang Chi et al.
Background: Thoracic aortic dissection (TAD) is a fatal cardiovascular disease characterized by vascular smooth muscle cell (VSMC) phenotypic remodeling and inflammation. Cannabinoid 1 (CB1/Cnr1) receptor has been implica...
Shanzhiside methyl ester attenuated cognitive impairment in diabetic mice by inhibiting neuroinflammation and glycolysis via HSP90AA1/HIF1A/STAT1 [0.03%]
山栀子甲酯通过HSP90AA1/HIF1A/STAT1信号通路抑制神经炎症和糖酵解减轻糖尿病小鼠的认知障碍作用研究
Tong Chen,Lijun Ai,Ruonan Shuang et al.
Tong Chen et al.
Background: Cognitive impairment is the common complication of diabetes, while its etiology remains not fully understood. Gardenia jasminoides is used in traditional Chinese medicine for clearing heat and detoxification. ...
Gastrodin promotes Alkbh5 nuclear localization and Gclm m6A demethylation to alleviate ferroptosis in ischemic stroke [0.03%]
姜半夏多效化合物促进ALKBH5入核及GCLM去甲基化缓解缺血性脑卒中细胞铁死亡
Jinsha Shi,Xiao Xiao,Zhao Wang et al.
Jinsha Shi et al.
Background: Ischemic stroke (IS) remains a major contributor to global morbidity and mortality, largely due to limited therapies and unclear pathogenesis. Gastrodin (GAS), a bioactive ingredient from traditional Chinese m...