The paradox of potency: Insights into emergent mechanisms of Ganoderma lucidum's antitumor effects [0.03%]
灵芝抗肿瘤作用的新兴机制及其功效悖论初探
Lingjie Luo,Pandeng Wang,Yuancheng Xu et al.
Lingjie Luo et al.
Background: An arms race between cancer cells and therapeutic pressure fuels drug resistance, immune evasion, and tumor heterogeneity, hindering therapy. Ganoderma lucidum (G. lucidum), a traditional Chinese medicine (TCM...
Juyuanjian attenuates sarcopenia through dual regulation of the Akt/FoxO1 and SIRT1/PGC-1α pathways [0.03%]
举元煎通过双向调节Akt/FoxO1和SIRT1/PGC-1α信号通路缓解肌肉减少症
Yibing Yan,Xihong Liu,Peiyuan Zhao et al.
Yibing Yan et al.
Background: Sarcopenia, an age-related degenerative disease, corresponds to "Qi Xu" syndrome in traditional Chinese medicine. Juyuanjian (JYJ), a classical Qi-tonifying formula, has shown potential against muscle atrophy ...
Chaihu Shugan San mitigates esophageal injury via AMPK-FUNDC1 mitochondrial homeostasis: Multi-omics insights [0.03%]
柴胡舒肝散通过AMPK-FUNDC1信号通路改善胃食管反流病的多组学研究
Xing Chang,Yicong Zhang,Wenshi Xu et al.
Xing Chang et al.
Background: Reflux esophagitis involves esophageal inflammatory injury associated with mitochondrial dysfunction and apoptosis. The role of AMPK/FUNDC1-mediated mitophagy in this process remains unclear. ...
Phenethyl isothiocyanate ameliorates high-fat diet-induced obesity by antagonizing hypothalamic leptin resistance [0.03%]
异硫氰酸苯乙酯通过拮抗下丘脑瘦素抵抗改善高脂饮食诱导的肥胖症
Jiqu Xu,Congcong Ma,Li Zhang et al.
Jiqu Xu et al.
Background: Phenethyl isothiocyanate (PEITC) is an isothiocyanate produced from the glucosinolate gluconasturtiin in cruciferous plants and has been shown to reduce fat accumulation. Hypothalamic leptin resistance is a ke...
Single-cell profiling uncovers kaempferol-mediated immunoregulation in the protection against experimental autoimmune hepatitis [0.03%]
单细胞谱系示踪揭示kaempferol通过调节免疫反应对自身免疫性肝炎的保护作用
Qingmiao Shi,Yuting He,Shen Shen et al.
Qingmiao Shi et al.
Background: Autoimmune hepatitis (AIH) is triggered by an aberrant immune response directed against hepatocyte autoantigens, ultimately leading to liver inflammation and hepatocellular damage. Kaempferol (KAE), a natural ...
Zuojin Pill ameliorates depression with gastrointestinal dysfunction via Parabacteroides distasonis [0.03%]
佐金丸通过副拟杆菌改善伴胃肠功能紊乱的抑郁模型小鼠病症
Dan Qiao,Yuzhen Huang,Chun Ge et al.
Dan Qiao et al.
Background: Brain-gut interaction disorders, such as functional dyspepsia (FD) comorbid with depression, are highly prevalent and severely affect patients' quality of life; however, the underlying mechanisms remain incomp...
Fuzheng Jiedu Tongluo Granule mitigates blood-brain barrier disruption after ischemic stroke via inhibiting transcytosis in cerebral vascular endothelial cells [0.03%]
补气解毒通络颗粒通过抑制脑血管内皮细胞跨胞转运减轻缺血性卒中后的血脑屏障破坏作用
Siyu Liu,Chang Li,Yong She et al.
Siyu Liu et al.
Background: The increased transcytosis in endothelial cells (EC) represents a significant secondary pathological event that results in BBB disruption following cerebral ischemia-reperfusion injury (CIRI). The Wnt/β-caten...
Apple derived extracellular vesicles as positive modulators of glial inflammation and gut-brain axis signaling [0.03%]
来源于苹果的外泌体对胶质细胞炎症和肠-脑轴信号具有积极作用
Maria Pia Cavaleri,Luna Ardondi,Ilaria Vitali et al.
Maria Pia Cavaleri et al.
Plant-derived extracellular vesicles (PDEVs) are emerging as bioactive dietary particles with the capacity to modulate mammalian physiology. Here, we characterize the structure and functional properties of apple-derived extracellular vesicl...
Neferine-enhanced Shenling Baizhu Tang potentiates anti-PD-1 therapy in colorectal cancer liver metastasis via CYP2E1-PPARα-mediated lipid reprogramming [0.03%]
.neferine增强神术汤通过CYP2E1-PPARα介导的脂质重塑促进抗PD-1治疗在结直肠癌肝转移中的作用
Xiaochun Zhang,Yang Yang,Meiqi Zhang et al.
Xiaochun Zhang et al.
Background: Immune checkpoint inhibitors elicit responses in merely 20-40% of patients with microsatellite instability-high or mismatch repair-deficient colorectal cancer (CRC), making immunotherapy resistance a formidabl...
Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial [0.03%]
含橄榄苦素的橄榄叶提取物辅助治疗可改善老年人牙周炎患者的牙周预后：一项随机对照试验中的代谢组学见解
Tamara Y Forbes-Hernández,Franklin G Vargas-Corral,Beatriz Bullón et al.
Tamara Y Forbes-Hernández et al.
Background: Periodontitis is a prevalent chronic inflammatory disease in older adults, often linked to systemic conditions and metabolic alterations. Standardized plant extracts may provide consistent adjunctive therapeut...