20(S)-ginsenoside Rg3 suppresses gastric cancer cell proliferation by inhibiting E2F-DP dimerization [0.03%]
原人参三醇型皂苷Rg3通过抑制E2F-DP二聚体来抑制胃癌细胞增殖
Fuqiang Li,Chengyu Cai,Fei Wang et al.
Fuqiang Li et al.
Background: Gastric cancer (GC) is a common and aggressive malignancy, with treatment options often limited by drug resistance and the adverse effects of targeted therapies and immunotherapy. Ginsenoside Rg3, a bioactive ...
Xiongshao Zhitong granules alleviate nitroglycerin-induced migraine by regulating the TRPV1-mediated NLRP3 inflammatory pathway in rats [0.03%]
熊绍痛膏通过调节TRPV1介导的NLRP3炎症小体信号通路缓解硝酸甘油诱导的大鼠偏头痛
Yuxi Wang,Song Yang,Xiaoyao Liu et al.
Yuxi Wang et al.
Background: Migraine is a prevalent neurological disorder accompanied by a considerable economic burden. Xiongshao Zhitong granules (XSZT) have anti-inflammatory and analgesic functions in the clinic and are used for migr...
Ginsenosides modulate immunity via TLR4/MyD88/NF-κB pathway and gut microbiota [0.03%]
人参皂苷通过TLR4/MyD88/NF-κB信号通路及肠道菌群调节免疫反应
Ying Li,Meng Zhang,Kaiyue Zhang et al.
Ying Li et al.
Background: Ginsenosides, the primary active compounds in Panax ginseng C. A. Mey., are well known for their potent immunomodulatory effects. However, their precise mechanisms, particularly concerning the "intestinal-meta...
Qi-Gu capsule alleviates osteoporosis by inhibiting mesenchymal stem cell senescence via the HIF-1α/AMPK axis [0.03%]
补肾益骨胶囊通过HIF-1α/AMPK轴抑制间充质干细胞衰老从而治疗骨质疏松症
Xuan Wan,Pengchao Xu,Xing Zhou et al.
Xuan Wan et al.
Background: Osteoporosis (OP) represents a systemic disease causing reduced bone mass and fragility fractures. Qigu Capsule (QGC), a traditional Chinese medicine, shows potential in alleviating human OP, but its precise m...
Buyang Huanwu Decoction stabilizes atherosclerotic vulnerable plaques by regulating intestinal flora, TLR4-NF-κB-NLRP3 inflammatory pathway and mitophagy [0.03%]
补阳还五汤通过调节肠道菌群、TLR4-NF-κB-NLRP3炎症通路及线粒体自噬稳定动脉粥样硬化易损斑块
Shi-Yao Chang,Yu-Ting Li,Hong-Yang Zhu et al.
Shi-Yao Chang et al.
Objective: This study explores the anti-atherosclerosis (AS) effects of Buyang Huanwu Decoction (BYHWD), focusing on its regulatory effects on the TLR4/NF-κB/NLRP3 inflammatory pathway, gut microbiota metabolites, and mi...
Gouqi-derived Nanovesicles (GqDNVs) promoted MC3T3-E1 cells proliferation and improve fracture healing [0.03%]
gouqi衍生的纳米囊泡(GqDNVs)促进MC3T3-E1细胞增殖并改善骨折愈合
Shiyin Xu,Zixuan Zhang,Xiaolei Zhou et al.
Shiyin Xu et al.
Background: Lycium barbarum L., also known as Gouqi, a traditional Chinese herbal medicine, is widely utilized in health care products and clinical therapies. Its muscle and bone strengthening efficacy has been recorded i...
HDCA alleviates Parkinson's disease symptoms by promoting autophagic degradation of α-synuclein in enteric neurons [0.03%]
HDAC抑制剂丁酸苯酯通过促进肠道神经元中α-突触核蛋白的自噬降解从而缓解帕金森病症状
Ren-Yu Kong,Jin-Bao Zhang,Xu Miao et al.
Ren-Yu Kong et al.
Introduction: Bile acids (BAs) are emerging as key modulators of Parkinson's disease (PD) through gut-brain interactions, yet their therapeutic potential remains underutilized. While BA imbalances contribute to PD pathoge...
Didang decoction improves gut microbiota and cognitive function in TDACD rats: Combined proteomics and 16S rRNA sequencing [0.03%]
DIDANG汤通过蛋白组学和16S rRNA测序联合分析改善痰湿阻滞型血管性痴呆大鼠认知障碍及肠道菌群失调的作用研究
Zihan Li,Caiyi Long,Jiajing Tao et al.
Zihan Li et al.
Background: Type 2 diabetes mellitus (T2DM) significantly elevates the risk of cognitive impairment. Didang Decoction (DDD), a classical Traditional Chinese Medicine (TCM) formula, has shown promise in alleviating diabeti...
Tongfu Xingshen capsule alleviates stroke-associated pneumonia-induced multiple organ injuries by modulating the gut microbiota and sphingolipid metabolism [0.03%]
通佛行神胶囊通过调节肠道菌群和鞘脂代谢缓解肺脓毒症致多器官损伤
Ruihua Wang,Changlian Gan,Baoying Gong et al.
Ruihua Wang et al.
Background: Stroke-associated pneumonia (SAP) represents a major complication and cause of death in patients suffering from intracerebral haemorrhage (ICH). It's urgent to develop more effective therapeutic strategies. To...
Ji-Ming-San enhances intestinal circadian rhythms and mitigates colitis in mice: The role of epithelial RORα [0.03%]
济鸣散调节肠道昼夜节律而改善小鼠结肠炎：核受体RORα的介导作用
Zhixi Pan,Jiahui Liu,Shubin Lin et al.
Zhixi Pan et al.
Background: Ji-Ming-San (JMS), a traditional Chinese medicine, exhibits time-dependent pharmacological effects, suggesting its potential as a circadian clock modulator. However, the precise mechanisms by which JMS regulat...