Targeting mitochondrial DNA-STING-NF-κB Axis-mediated microglia activation by cryptotanshinone alleviates ischemic retinopathy [0.03%]
靶向隐丹参酮通过线粒体DNA-STING-NF-κB轴介导的微胶质细胞活化来缓解缺血性视网膜病变
Wanlu Qiu,Zhihua Zheng,Jiaojiao Wang et al.
Wanlu Qiu et al.
Background: Ischemic retinopathy, a leading cause of vision impairment, involves oxidative stress and dysregulated inflammation, with microglia playing a key role. Cryptotanshinone (CTS), a bioactive compound from Salvia ...
Bioactive components of Jiedu Sangen decoction against colorectal cancer: A novel and comprehensive research strategy for natural drug development [0.03%]
解毒散结方抗肠癌活性成分研究及天然药物研发新模式探索
Xueer Zheng,Chao Shi,Ying Xie et al.
Xueer Zheng et al.
Background: Jiedu Sangen Decoction (JSD) is widely used in the treatment of colorectal cancer (CRC) patients in southern China due to its good clinical efficacy, but the effective active ingredients are still unknown. ...
Geniposide via enema alleviates colitis by modulating intestinal flora and bile acid metabolites, inhibiting S100A8/S100A9/NF-κB, and promoting TGR5 inhibition of NLRP3 inflammasome [0.03%]
结霜草素灌肠通过调节肠道菌群和胆汁酸代谢、抑制S100A8/S100A9/NF-κB以及促进TGR5抑制NLRP3炎性小体治疗结肠炎
Bao-Xin Zheng,Yan Yi,Xing-Wen Wang et al.
Bao-Xin Zheng et al.
Background: Geniposide (GE) has potential efficacy in treating ulcerative colitis (UC). However, its reactivity can be affected by rapid degradation after oral administration. Furthermore, increasing oral doses may lead t...
KAJF alleviated colorectal cancer liver metastasis by reshaping the gut microbiota and inhibiting M2-like macrophage polarization [0.03%]
KAJF通过重塑肠道菌群和抑制M2型巨噬细胞极化来缓解结直肠癌肝转移
Zongmei Zheng,Yizhao Du,Hua Jiang et al.
Zongmei Zheng et al.
Background: Colorectal cancer liver metastasis (CRLM) represents one of the most severe complications of colorectal cancer (CRC), often associated with unfavorable prognosis. The herbal formulation Kang-Ai-Jing-Fang (KAJF...
Gastrodin attenuates hypercholesterolaemia through regulating the PCSK9/LDLR signalling pathway by suppressing HNF-1α and activating FoxO3a [0.03%]
姜半夏皂苷通过抑制HNF-1α和激活FoxO3a调节PCSK9/LDLR信号通路从而降低高胆固醇血症的作用机制研究
Yaowen Zhang,Lan Han,Qiyuan Ning et al.
Yaowen Zhang et al.
Background: Hypercholesterolaemia is a prevalent etiological factor of cardiovascular diseases (CVDs). Gastrodin (Gas), the paramount active constituent in Gastrodia elata Bl., has lipid-lowering and anti-inflammatory pro...
Artesunate ameliorates diabetic xerostomia in rats through regulating oral microbiota and metabolic profile in salivary gland based on NF-κB/NLRP3 signaling pathway [0.03%]
艺术酸铵通过NF-κB / NLRP3信号通路调节口腔微生物群和唾液腺代谢谱来改善大鼠糖尿病口干症
Siqin Zhang,Jun Zhao,Yuxiang Zhan et al.
Siqin Zhang et al.
Background: Artemisia annua. L, as a valuable Chinese medicine, has been applied for millennia in China. Its major active ingredient, artemisinin, has demonstrated diverse pharmacological properties, including anti-inflam...
Magnesium Lithospermate B Protects Against Ischemic AKI-to-CKD progression via regulating the KLF5/CDK1/Cyclin B1 pathway [0.03%]
镁丹参素B通过调节KLF5/CDK1/Cyclin B1信号通路对抗缺血性急性肾损伤向慢性肾脏病进展的作用及机制研究
Liyu Lin,Daoqi Shen,Yiqi Su et al.
Liyu Lin et al.
Background: Ischemia-reperfusion injury (IRI) is the primary cause of acute kidney injury (AKI), which can result in chronic kidney disease (CKD) with renal fibrosis. Magnesium lithospermate B (Mlb), a bioactive compound ...
Senolytic treatment alleviates cochlear senescence and delays age-related hearing loss in C57BL/6J mice [0.03%]
senolytic治疗可减轻C57BL/6J小鼠耳蜗衰老并延缓年龄相关性听力下降
Yi Chen,Hongming Huang,Yuelian Luo et al.
Yi Chen et al.
Background: Age-related hearing loss (ARHL) is a prevalent sensory deficit that significantly affects quality of life in older individuals. Cellular senescence contributes to various age-related degenerative disorders. Ho...
Total saponins from Panax japonicus alleviate insulin resistance via exosomal miR204/Elovl6-mediated adipocyte-macrophage crosstalk [0.03%]
日本人参总皂苷通过外泌体miR204/Elovl6介导的脂肪细胞-巨噬细胞串话缓解胰岛素抵抗
Qianqian Yao,Rui Wang,Hailin Wang et al.
Qianqian Yao et al.
Background: Insulin resistance (IR) is a key factor in the development of type 2 diabetes, and M2-like macrophages are important in maintaining normal glucose homeostasis. Our previous research has demonstrated that the t...
Integrated network pharmacology, metabolomics, and microbiome studies to reveal the therapeutic effects of Anacyclus pyrethrum in PD-MCI mice [0.03%]
整合网络药理学、代谢组学和微生物组研究揭示黄精回奶草对PD-MCI小鼠的治疗作用
Tayier Tuersong,Qin Fen Wu,Yan Chen et al.
Tayier Tuersong et al.
Background: Anacyclus pyrethrum (l.) DC has potential value in treating Parkinson's disease (PD)-mild cognitive impairment (MCI), manifesting as impaired memory, attention, executive function, and language. However, the s...