Echinacoside alleviates type 2 diabetes mellitus through inhibiting hepatic gluconeogenesis via gut bacterial-fungal trans-kingdom network reconstruction [0.03%]
基于肠道菌藻互作网络重建发现ECH通过抑制肝脏糖异生改善2型糖尿病研究
Li Fan,Jian Liu,Lin Li et al.
Li Fan et al.
Background: Echinacoside (ECH), a natural phenylethanoid glycoside, has demonstrated protective effects against type 2 diabetes mellitus (T2DM). However, the mechanism underlying the low bioavailability yet advantageous a...
Luteolin alleviates estrogen deficiency-induced muscle atrophy via targeting SLC7A11-mediated ferroptosis [0.03%]
黄酮类化合物芦丁通过靶向SLC7A11介导的铁死亡缓解雌激素缺乏引起的肌肉萎缩
Yu Liu,Honglin Chen,Kun Chen et al.
Yu Liu et al.
Background: Skeletal muscle atrophy, which is a debilitating condition exacerbated by estrogen deficiency, lacks effective therapeutic interventions. Although ferroptosis (an iron-dependent form of cell death driven by li...
Natural products and ferroptosis: A novel approach for heart failure management [0.03%]
天然产物与铁死亡：心力衰竭管理的新途径
Zeyu Zhang,Zhihua Yang,Shuai Wang et al.
Zeyu Zhang et al.
Background: The discovery of ferroptosis has brought a revolutionary breakthrough in heart failure treatment, and natural products, as a significant source of drug discovery, are gradually demonstrating their extraordinar...
Neixiao-ruanmai decoction No 2 improves carotid atherosclerosis by modulating gut microbiota and inhibiting TLR4/NF-κB pathway activation [0.03%]
内消软脉汤第2号通过调节肠道微生物群和抑制TLR4/NF-κB通路激活改善颈动脉粥样硬化
Hanrui Ji,Zhizhi Dong,Yanan Yang et al.
Hanrui Ji et al.
Background: Carotid atherosclerosis(CAs) plaques are challenging to reverse. Neixiao-Ruanmai Decoction No 2(NXRMT No 2), a Traditional Chinese Medicine (TCM) decoction, has shown potential in treating CAs. However, while ...
Artemisinin alleviates ischemic stroke injury and promotes neurogenesis through PPARγ-mediated M2 polarization of microglia [0.03%]
青蒿素通过PPARγ介导的小胶质细胞M2极化缓解缺血性脑卒中损伤并促进神经发生
Lin Li,Huiqin Hu,Weifeng Jiang et al.
Lin Li et al.
Background: Ischemic stroke (IS) remains a challenge in clinical treatment due to limited therapeutic options. While artemisinin (ART), an antimalarial drug, shields against acute IS via anti-inflammatory, antioxidant, an...
Qingre Sanjie Formula alleviates atherosclerosis by promoting LXR-α/ABCG5/G8-mediated reverse cholesterol transport and bile acid synthesis [0.03%]
清热三解方通过促进LXR-α/ABCG5/G8介导的胆固醇逆向转运和胆汁酸合成治疗动脉粥样硬化
Xiao Li,Xianglong Huang,Keyan Song et al.
Xiao Li et al.
Background: Atherosclerosis is the leading cause of cardiovascular disease-related morbidity and mortality. The traditional Chinese medicine Qingre Sanjie Formula (QRSJF), composed of Prunellae Spica, Sargassum, Fritillar...
Celastrol enhanced CD8+T cell immunity in melanoma by targeting SHP2 and upregulating MHC-I [0.03%]
雷公藤红素通过抑制SHP2提高黑色素瘤中MHCI表达和CD8+t细胞免疫功能
Qing Kong,Suqing Liu,Shan He et al.
Qing Kong et al.
Background: Celastrol (CEL) has demonstrated promising anti-cancer properties, yet its specific mechanisms against melanoma remain insufficient. This study investigated the CEL's anti-tumor effects and determined its pote...
Berbamine targets the FKBP12-rapamycin-binding (FRB) domain of the mTOR complex to promote microglial autophagy and ameliorate neuroinflammation in Alzheimer's disease [0.03%]
伯巴明通过靶向mTOR复合体的FKBP12-雷帕霉素结合（FRB）域促进小胶质细胞自噬并缓解阿尔茨海默病中的神经炎症
Pingyuan Ge,Siqi Guo,Pingping Wang et al.
Pingyuan Ge et al.
Background: Berbamine (BBM), a natural bisbenzylisoquinoline alkaloid, has demonstrated promising effects in ameliorating pathological process and inflammation response in central neuronal system (CNS). Alzheimer's diseas...
A comprehensive pharmacology study reveals the molecular mechanisms underlying the antidepressant effects of Gastrodiae Rhizoma [0.03%]
一项全面的药理研究揭示了天麻抗抑郁的作用机制
Pei Liu,Zhihuang Zhao,Haili Zhang et al.
Pei Liu et al.
Background: Gastrodiae Rhizoma (GR) and its extract have been widely used in the treatment of depression, but the underlying mechanism of its antidepressant effects is unclear due to its numerous components. ...
Targeting STING and protecting mitochondrial function with Nephropathy Ⅱ decoction to alleviate renal fibrosis [0.03%]
II号肾病方通过靶向STING和保护线粒体功能缓解肾纤维化
Yujiu Gao,Tingting Wei,Linjie Mu et al.
Yujiu Gao et al.
Background: Nephrology II Decoction (NED), a compound from traditional Chinese medicine, has been used in the clinical treatment of chronic kidney disease (CKD) for a long time. However, the specific active ingredients an...