Costunolide: Targeting endothelial cell PANoptosis to mitigate lung injury in acute pancreatitis mice [0.03%]
costunolide：通过靶向内皮细胞PANoptosis减轻急性胰腺炎小鼠肺损伤
Peng Ge,Yalan Luo,Jie Liu et al.
Peng Ge et al.
Background: Acute pancreatitis (AP) presents several critical risks, among which acute lung injury (ALI) is one of the most severe complications. Previous research has highlighted the anti-inflammatory properties of costu...
Structural characterization of polysaccharides from Lygodium japonicum (Thunb.) Sw. and its inhibition ability in calcium oxalate renal stone [0.03%]
Lygodium japonicum (Thunb.) Sw。多糖的结构表征及其抑制草酸钙肾结石的能力
Chun-Yao Li,Quan Zhang,Xin-Yu Shi et al.
Chun-Yao Li et al.
Background: Kidney stone is a prevalent abnormal mineralization disease characterized by high incidence and recurrence rates. Current pharmacological interventions for kidney stone predominantly rely on potassium citrate ...
The neuroprotective effect of 10-hydroxy-2-decenoic acid in traumatic brain injury by inhibiting copper-mediated neuronal pyroptosis [0.03%]
10-羟基-癸二酸通过抑制铜介导的神经元焦亡在创伤性脑损伤中发挥神经保护作用
Xinqi Huang,Yumei An,Jingxuan Liu et al.
Xinqi Huang et al.
Background: 10‑hydroxy-2-decenoic acid (10-HDA), the major fatty acid in royal jelly, exhibits antibacterial, anti-inflammatory, and antioxidant properties, suggesting its potential therapeutic benefits for traumatic bra...
Formononetin suppresses colitis-associated colon cancer by targeting lipid synthesis and mTORC2/Akt signaling [0.03%]
.formsink-536409 .forminator-blocks-wrapper { visibility: visible; }_FORMONONE丁素通过靶向脂质合成和mTORC2/Akt信号抑制结肠炎相关的结直肠癌
Mingxiu Liu,Canjiao Yang,Xingju Peng et al.
Mingxiu Liu et al.
Background: Colitis-associated colon cancer (CAC) is a serious gastrointestinal malignancy, with a significantly increased incidence among patients with inflammatory bowel disease, posing major challenges to patients' qua...
Curcuminoids WM03 inhibits ovarian cancer cisplatin-resistant cells proliferation and reverses cisplatin resistance by targeting DYRK2 [0.03%]
姜黄素衍生物WM03通过靶向DYRK2抑制卵巢癌顺铂耐药细胞的增殖并克服顺铂耐药性
Min-Jie Zhang,Xiaoxi Wan,Mengna Shi et al.
Min-Jie Zhang et al.
Purpose: Cisplatin is a common chemotherapy agent used to treat ovarian cancer and cisplatin resistance is the most common consequence after its treatment. Curcumin has been shown to effectively inhibit the proliferation ...
Peiyuan Ningshen-ointment alleviates learning and memory impairment induced by sleep deprivation through activating the cAMP/PKA signaling pathway [0.03%]
宁神培元膏通过激活cAMP/PKA信号通路缓解睡眠剥夺所致的学习记忆损伤
Xiao-Yu Wei,Fu-Ping Xu,Xiang-Bin Chen et al.
Xiao-Yu Wei et al.
Background: Sleep Deprivation (SD) seriously impacts the brain's learning and memory functioning, and the treatment methods and their efficacy are limited. PYNS ointment (Peiyuan Ningshen-ointment) is an herbal ointment c...
Crataegus pinnatifida polysaccharide alleviates DSS-induced colitis in mice by regulating the intestinal microbiota and enhancing arginine biosynthesis [0.03%]
Crataegus pinnatifida多糖通过调节肠道菌群和增强精氨酸生物合成缓解DSS诱导的小鼠结肠炎
Fan-Hao Wei,Wen-Yin Xie,Pei-Sen Zhao et al.
Fan-Hao Wei et al.
Background: The development of effective and safe dietary supplements is essential for both the prevention and management of ulcerative colitis (UC), as its pathogenesis is intricate and difficult to completely resolve. C...
Procyanidin C1 ameliorates aging-related skin fibrosis through targeting EGFR to inhibit TGFβ/SMAD pathway [0.03%]
procyanidin C1通过靶向EGFR抑制TGFβ/SMAD途径来改善与衰老相关的皮肤纤维化
Jun-Han Wang,Min Li,Peng-Fei Xie et al.
Jun-Han Wang et al.
Background: Aging-related skin fibrosis (SF) is a complex condition with limited treatment options. Procyanidin C1 (PCC1), a natural polyphenolic compound with demonstrated senolytic activity, has emerged as a potential t...
Hesperidin mitigated deoxynivalenol-induced liver injury by inhibiting ROS/ P53/ PGC-1α-mediated disruption of mitochondrial dynamics and PANoptosis [0.03%]
柚皮素通过抑制ROS/P53/PGC-1α介导的线粒体动态紊乱和PANoptosis缓解脱氧雪腐镰刀菌烯醇致肝损伤
Xin Wang,Tong Nie,Aqun Li et al.
Xin Wang et al.
Background: Deoxynivalenol (DON) is a physico-chemically stable food contaminant that is difficult to destroy during food production and culinary processing. Consumption of food contaminated with DON can impair the liver'...
Intestinal IL-17 family orchestrates microbiota-driven histone deacetylation and promotes Treg differentiation to mediate the alleviation of asthma by Ma-Xing-Shi-Gan decoction [0.03%]
麻杏石甘汤通过促进肠道调节T细胞分化介导哮喘的缓解：机制上，肠源性IL-17家族调控微生物群触发的组蛋白去乙酰化作用
Yanfei Hong,Jiaqi Cui,Guichuan Xu et al.
Yanfei Hong et al.
Background: Gut microbiota imbalance is well-known as one important trigger of allergic asthma. Ma-Xing-Shi-Gan decoction (MXSG) is a traditional Chinese medicine prescription with ideal clinical efficacy on asthma. Howev...