Effect of emodin on Streptococcus suis by targeting β-ketoacyl-acyl carrier protein synthase Ⅱ [0.03%]
大黄素通过靶向β-酮脂酰基acyl载体蛋白合成酶II抑制猪链球菌生长的作用研究
Jun Wang,Yongzheng Liu,Chongxiang Sun et al.
Jun Wang et al.
Background: Streptococcus suis is a zoonotic pathogen that causes meningitis, septicaemia, endocarditis, arthritis, and pneumonia in human beings. With the increasing prevalence of S. suis infections and a general decline...
Oleanolic acid derivative OA17 inhibits trophoblast apoptosis by suppressing HIF-1α nuclear translocation in SLE-associated adverse pregnancy outcomes [0.03%]
奥勒烷酸衍生物OA17通过抑制HIF-1α核转位抑制系统性红斑狼疮相关不良妊娠结局中的胎盘细胞凋亡
Mengqi Zhou,Lin Jin,Pan Wang et al.
Mengqi Zhou et al.
Background: Systemic lupus erythematosus (SLE) primarily affects women of reproductive age and is associated with a high incidence of adverse pregnancy outcomes (APOs). Recent studies reveal that elevated HIF-1α expressi...
The efficacy and toxicity equilibrium of emodin for liver injury: A bidirectional meta-analysis and machine learning [0.03%]
大黄酚治疗肝损伤的有效性与毒性的平衡：双向meta分析和机器学习方法
Sihan Hu,Xiaochuan Guo,Lang Tu et al.
Sihan Hu et al.
Background: Emodin, a hepatoprotective agent derived from various herbs, exhibits dual effects on liver injury, necessitating further investigation into its therapeutic and toxic properties. Traditional meta-analyses lack...
Natural products targeting ferroptosis in depression: Research progress and therapeutic prospects [0.03%]
天然产物在抑郁症铁死亡靶点中的研究进展及治疗前景
Jing Liu,Gaoju Zhang,Liping Chen et al.
Jing Liu et al.
Background: Depression is recognized as a chronic mental illness, also influenced by neurotransmitter homeostasis, with its incidence increasing annually worldwide. This condition inflicts significant physical and psychol...
Fuling Wenxin formula treats "Qi-Yin deficiency" arrhythmia by regulating the dilated cardiomyopathy and adrenergic signaling pathway in cardiomyocytes [0.03%]
茯苓温心汤通过调控心脏自主神经-儿茶酚胺信号通路治疗气阴虚心律失常的作用机制研究
Sheng-Ran Yang,Zhi-Shu Tang,Yan-Ru Liu et al.
Sheng-Ran Yang et al.
Background: Arrhythmia, a common cardiac disorder, presents a considerable risk to human health, characterized by symptoms including palpitations and chest tightness, and may result in sudden cardiac death. The Fuling Wen...
Cycloastragenol reduces inflammation in CLP-induced septic MICE by suppressing TLR4 signaling pathways [0.03%]
环三棱碱通过抑制TLR4信号途径减少CLP诱导的脓毒症小鼠炎症反应
Guanghong Chen,Wanyu Wang,Baoyi Guan et al.
Guanghong Chen et al.
Background: Aggressive systemic inflammation due to activation of macrophage-derived excessive immune responses is a critical cause of sepsis leading to clinical death. The effect of cycloastragenol (CAG) on cecal ligatio...
ATF3 restoration as a potential strategy in managing ulcerative colitis: Implications from Sishen pill research [0.03%]
基于四神丸的研究阐释ATF3修复在溃疡性结肠炎治疗中的潜在价值
Yutong Jin,Xuetao Dong,Weilong Zhong et al.
Yutong Jin et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited therapeutic options, particularly for moderate-to-severe cases. The present study evaluated the therapeutic potential of Sishen Pill...
Pien Tze Huang plus entecavir improves hepatic fibrosis in Chinese patients with chronic hepatitis B [0.03%]
pien tze huang联合恩替卡韦可改善慢性乙肝患者的肝纤维化
Xin Zhang,Liwen Zhang,Longshan Ji et al.
Xin Zhang et al.
Background: Pien Tze Huang (PTH), a well-established traditional Chinese medicine compound, has exhibited anti-hepatic fibrosis properties both in vitro and in vivo animal models, but the randomized clinical trials to eva...
A novel antioxidant and anti-inflammatory carboxymethylcellulose/chitosan hydrogel loaded with cannabidiol promotes the healing of radiation-combined wound skin injury in the 60Co γ-irradiated mice [0.03%]
一种新型抗氧化和抗炎的羧甲基纤维素/壳聚糖水凝胶，负载大麻二酚，可促进钴-60γ射线照射小鼠合并伤口皮肤损伤的修复
Wei Zhou,Long Zhu,Xiaoran Zu et al.
Wei Zhou et al.
Background: Combined radiation and wound skin injury (RW) are frequently observed in patients undergoing tumor surgery plus radiotherapy, and but specific treatment is lacking. Chitosan (CS) and carboxymethyl cellulose (C...
Mechanistic study of a triterpenoid-enriched fraction derived from Cynomorium songaricum against NAFLD: An integrative elucidation [0.03%]
基于肉苁蓉的三萜富集组分抗非酒精性脂肪肝病作用研究：机制探讨及整合阐释
Zhihao Liu,Qixiang Shang,Juanjuan Cheng et al.
Zhihao Liu et al.
Background: Non-alcoholic fatty liver disease (NAFLD) is a growing global health concern linked to metabolic dysfunction and inflammation. Traditional Chinese Medicine (TCM), with its emphasis on restoring balance and har...